The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies (Q37401193)

20 August 2017

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title

The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies (English)

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20 August 2017

neoplastic stem cells

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3

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20 August 2017

Brett G Hollier

1

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PubMed ID

19242781

20 August 2017

Kurt Evans

series ordinal

2

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20 August 2017

26 February 2009

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Journal of Mammary Gland Biology and Neoplasia

20 August 2017

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20 August 2017

14

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20 August 2017

1

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20 August 2017

29-43

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https://scigraph.springernature.com/pub.10.1007/s10911-009-9110-3

20 August 2017

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Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?

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The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes

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12 December 2020

Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers

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Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

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12 December 2020

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

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12 December 2020

Metaplastic carcinomas of the breast. IV. Squamous cell carcinoma of ductal origin

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12 December 2020

Metaplastic carcinomas of the breast. II. Spindle cell carcinoma

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12 December 2020

Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

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12 December 2020

MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme

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12 December 2020

TGF-beta and epithelial-to-mesenchymal transitions

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12 December 2020

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

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12 December 2020

DIFFERENTIATION PATHWAYS IN PRIMARY INVASIVE BREAST CARCINOMA AS SUGGESTED BY INTERMEDIATE FILAMENT AND BIOPATHOLOGICAL MARKER EXPRESSION

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12 December 2020

Inflammatory breast cancer (IBC) and patterns of recurrence: understanding the biology of a unique disease

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12 December 2020

Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

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12 December 2020

Gene expression profiling of breast cell lines identifies potential new basal markers.

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12 December 2020

Transitions between epithelial and mesenchymal states in development and disease

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12 December 2020

Epithelium-mesenchyme transition during neural crest development.

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12 December 2020

Cancer statistics, 2005

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12 December 2020

Vimentin contributes to human mammary epithelial cell migration.

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12 December 2020

Expression profiling of epithelial plasticity in tumor progression

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12 December 2020

Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells.

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12 December 2020

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

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12 December 2020

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12 December 2020

Epithelial cell plasticity in development and tumor progression

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12 December 2020

Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis

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12 December 2020

Stromal effects on mammary gland development and breast cancer

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12 December 2020

WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells

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12 December 2020

Immunolocalization of a human basal epithelium specific keratin in benign and malignant breast disease.

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12 December 2020

Cell-type-specific responses to chemotherapeutics in breast cancer

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12 December 2020

Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice

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12 December 2020

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

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12 December 2020

Molecular portraits of human breast tumours

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12 December 2020

Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.

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12 December 2020

Evidence for a stem cell hierarchy in the adult human breast

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12 December 2020

Combined-modality treatment of inflammatory breast carcinoma: twenty years of experience at M. D. Anderson Cancer Center

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12 December 2020

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12 December 2020

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

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12 December 2020

Differential cadherin expression: potential markers for epithelial to mesenchymal transformation during tumor progression

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12 December 2020

Neural crest specification: migrating into genomics

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12 December 2020

Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype

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12 December 2020

Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity

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12 December 2020

The CD44+/CD24- phenotype is enriched in basal-like breast tumors

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12 December 2020

Epithelial mesenchymal transition traits in human breast cancer cell lines.

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12 December 2020

Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition

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12 December 2020

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

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12 December 2020

The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

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12 December 2020

The prognostic role of a gene signature from tumorigenic breast-cancer cells.

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12 December 2020

BIOLOGY OF HEMATOPOIETIC STEM CELLS AND PROGENITORS: Implications for Clinical Application

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12 December 2020

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

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12 December 2020

Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

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12 December 2020

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress

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12 December 2020

let-7 regulates self renewal and tumorigenicity of breast cancer cells

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12 December 2020

CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis

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12 December 2020

Targeting Bcl-2 and Bcl-X with nonpeptidic small-molecule antagonists

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12 December 2020

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

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12 December 2020

HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion.

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12 December 2020

The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern

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12 December 2020

A twist for survival and cancer progression

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12 December 2020

Repeated observation of breast tumor subtypes in independent gene expression data sets

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12 December 2020

Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells.

1 reference

12 December 2020

Basal carcinoma of the breast revisited: an old entity with new interpretations.

1 reference

12 December 2020

Epithelial-to-mesenchymal transition confers resistance to apoptosis in three murine mammary epithelial cell lines

1 reference

12 December 2020

Metaplastic breast carcinoma. Rare form of mammary cancer

1 reference

12 December 2020

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

1 reference

12 December 2020

The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

1 reference

12 December 2020

Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers

1 reference

12 December 2020

Early role of Fsp1 in epithelial-mesenchymal transformation

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12 December 2020

Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition

1 reference

12 December 2020

Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

1 reference

12 December 2020

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways

1 reference

12 December 2020

Challenges in the development of anti-epidermal growth factor receptor therapies in breast cancer

1 reference

12 December 2020

The epithelial-mesenchymal transition generates cells with properties of stem cells

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12 December 2020

The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer

1 reference

12 December 2020

Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of beta-catenin phosphorylation.

1 reference

12 December 2020

The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation

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12 December 2020

Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients

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12 December 2020

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

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12 December 2020

CCN6 (WISP3) as a new regulator of the epithelial phenotype in breast cancer

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12 December 2020

Vimentin and epithelial-mesenchymal transition in human breast cancer--observations in vitro and in vivo.

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12 December 2020

Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.

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12 December 2020

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

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12 December 2020

Hormonal control of alveolar development and its implications for breast carcinogenesis

1 reference

12 December 2020

Development and characterization of gemcitabine-resistant pancreatic tumor cells.

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12 December 2020

Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?

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12 December 2020

Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines

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12 December 2020

EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 receptors have different effects on survival.

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12 December 2020

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

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12 December 2020

Modulations of the epithelial phenotype during embryogenesis and cancer progression

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12 December 2020

Identification of human brain tumour initiating cells

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12 December 2020

Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype

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12 December 2020

Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysis

1 reference

12 December 2020

Cancer stem cells: are we missing the target?

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12 December 2020

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

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12 December 2020

Molecular definition of breast tumor heterogeneity

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12 December 2020

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12 December 2020

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

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12 December 2020

Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue

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12 December 2020

Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells

1 reference

12 December 2020

The fallacy of epithelial mesenchymal transition in neoplasia

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12 December 2020

Mesenchyme to epithelium transition during development of the mammalian kidney tubule

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12 December 2020

Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes.

1 reference

12 December 2020

Deaths: leading causes for 2004.

1 reference

12 December 2020

Stem cells, cancer, and cancer stem cells

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12 December 2020

Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: inhibition by gefitinib ('Iressa', ZD1839).

1 reference

12 December 2020

Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells

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12 December 2020

Epithelial-mesenchymal transition and the invasive potential of tumors.

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12 December 2020

Identification and expansion of human colon-cancer-initiating cells

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12 December 2020

Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition

1 reference

12 December 2020

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1 reference

12 December 2020

Breast cancer metastasis: markers and models

1 reference

12 December 2020

Complex networks orchestrate epithelial-mesenchymal transitions

1 reference

12 December 2020

The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study

1 reference

12 December 2020

Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development

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12 December 2020

Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis

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12 December 2020

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

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12 December 2020

Prospective identification of tumorigenic breast cancer cells

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12 December 2020

Gelsolin as a negative prognostic factor and effector of motility in erbB-2-positive epidermal growth factor receptor-positive breast cancers

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12 December 2020

Purification and unique properties of mammary epithelial stem cells

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12 December 2020

Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy

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12 December 2020

Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis

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12 December 2020

Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss

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12 December 2020

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

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12 December 2020

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

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12 December 2020

Generation of a functional mammary gland from a single stem cell

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12 December 2020

Epithelial-mesenchymal transitions in development and pathologies

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12 December 2020

Irradiation-induced epithelial-mesenchymal transition (EMT) related to invasive potential in endometrial carcinoma cells

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12 December 2020

Cancer as an overhealing wound: an old hypothesis revisited

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12 December 2020

Disease-free and overall survival after pathologic complete disease remission of cytologically proven inflammatory breast carcinoma axillary lymph node metastases after primary systemic chemotherapy

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12 December 2020

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes

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12 December 2020

Snail blocks the cell cycle and confers resistance to cell death

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12 December 2020

Wound healing--aiming for perfect skin regeneration

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12 December 2020

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

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12 December 2020

The transcriptional repressor Snail promotes mammary tumor recurrence

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12 December 2020

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

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12 December 2020

Short interfering RNA directed against TWIST, a novel zinc finger transcription factor, increases A549 cell sensitivity to cisplatin via MAPK/mitochondrial pathway

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12 December 2020

Epithelial-mesenchymal transitions in tumour progression

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12 December 2020

10.1007/S10911-009-9110-3

Identifiers

DOI

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20 August 2017

1 reference

PubMed ID

19242781