Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages (Q37401470)

20 August 2017

Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages (English)

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20 August 2017

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Natalie E Freeman

1

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20 August 2017

Antonio E Rusinol

2

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20 August 2017

MacRae Linton

3

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20 August 2017

David L Hachey

4

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20 August 2017

Sergio Fazio

5

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20 August 2017

Michael S Sinensky

6

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20 August 2017

Douglas Thewke

7

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20 August 2017

1 July 2005

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Journal of Lipid Research

20 August 2017

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20 August 2017

46

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20 August 2017

9

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20 August 2017

1933-1943

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Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: in vivo and in vitro studies

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

A novel method to determine specificity and sensitivity of the TUNEL reaction in the quantitation of apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Oxidized LDL-induced injury and apoptosis in atherosclerosis. Potential roles for oxysterols

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Macrophage death and the role of apoptosis in human atherosclerosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Cholesterol and phospholipid metabolism in macrophages

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Mammalian acyl-CoA:cholesterol acyltransferases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Oxysterols: modulators of cholesterol metabolism and other processes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Intracellular cholesterol transport.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Acyl-coenzyme A:cholesterol acyltransferase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

7 beta-hydroperoxycholest-5-en-3 beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Somatic cell genetics and the study of cholesterol metabolism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Cholesterol transport between cells and high-density lipoproteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Oxidized low-density lipoprotein is associated with apoptosis of vascular smooth muscle cells in human atherosclerotic plaques

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Free cholesterol loading of macrophages induces apoptosis involving the fas pathway.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Apoptosis in human monocyte-macrophages exposed to oxidized low density lipoprotein.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Isolation and characterization of Chinese hamster ovary cell mutants deficient in acyl-coenzyme A:cholesterol acyltransferase activity.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Capillary GC quantification of cholesterol oxidation products in plasma lipoproteins of fasted humans

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

A 25-hydroxycholesterol-resistant cell line deficient in acyl-CoA: cholesterol acyltransferase

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis?

26 June 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M500101-JLR200

Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M500101-JLR200

Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M500101-JLR200

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M500101-JLR200

Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M500101-JLR200

Toxicity of oxysterols to human monocyte-macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M500101-JLR200

Preferential pharmacological inhibition of macrophage ACAT increases plaque formation in mouse and rabbit models of atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M500101-JLR200

Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

Characterization of endothelial cell injury by cholesterol oxidation products found in oxidized LDL.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768430

The separation of complex lipide mixtures by the use of silicic acid chromatography

2 October 2018

1 reference

12 December 2020

Isolation of a somatic cell mutant resistant to the induction of apoptosis by oxidized low density lipoprotein

1 reference

12 December 2020

25-Hydroxycholesterol activates a cytochrome c release-mediated caspase cascade

1 reference

12 December 2020

Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035

1 reference

12 December 2020

The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one

1 reference

12 December 2020

Lipids and oxidised lipids in human atheroma and normal aorta

1 reference

12 December 2020

Apoptosis induced by oxysterols in murine lymphoma cells and in normal thymocytes

1 reference

12 December 2020

Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol

1 reference

12 December 2020

Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry

1 reference

12 December 2020

Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma

1 reference

12 December 2020

Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages

1 reference

12 December 2020

Oxysterol-induced apoptosis in human monocytic cell lines

1 reference

12 December 2020

Quantitative analysis of hydrophobic amine inhibition of intracellular cholesterol transport

1 reference

12 December 2020

Roles of multiple oxidized LDL lipids in cellular injury: dominance of 7 beta-hydroperoxycholesterol

1 reference

12 December 2020

Synthesis of highly pure dolichyl and cholesteryl esters

1 reference

12 December 2020

Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the 'response to injury' hypothesis.

1 reference

12 December 2020

The fate of cholesterol exiting lysosomes

1 reference

12 December 2020

7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque

1 reference

12 December 2020

Expression of ACAT-1 protein in human atherosclerotic lesions and cultured human monocytes-macrophages

1 reference

12 December 2020

Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production

1 reference

12 December 2020

Oxysterols and atherosclerosis

1 reference

12 December 2020

Receptors for oxidized low density lipoprotein.

1 reference

12 December 2020

10.1194/JLR.M500101-JLR200

Identifiers

DOI

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

15995174

1 reference