Platelet factor 4 (Q3740205)

Chemokine interleukin-8-like superfamily

1 reference

Chemokine interleukin-8-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CXC Chemokine domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CXC chemokine, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

8 April 2019

New insights into the negative regulation of hematopoiesis by chemokine platelet factor 4 and related peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

CXCR3 chemokine receptor binding

1 reference

8 April 2019

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

3 references

8 April 2019

Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

5 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02776&geneProductId=UniProtKB:P02776

31 October 2017

The human plasma proteome: a nonredundant list developed by combination of four separate sources

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02776&geneProductId=UniProtKB:P02776

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02776&geneProductId=UniProtKB:P02776

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02776&geneProductId=UniProtKB:P02776

31 October 2017

Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02776&geneProductId=UniProtKB:P02776

platelet alpha granule lumen

IC

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

1 reference

8 April 2019

Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

8 April 2019

The human plasma proteome: a nonredundant list developed by combination of four separate sources

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

collagen-containing extracellular matrix

IEA

1 reference

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

cytokine-mediated signaling pathway

HDA

biological process

1 reference

8 April 2019

Signal transduction of chemokine platelet factor 4 in human erythroleukemia cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

chemokine-mediated signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

positive regulation of macrophage differentiation

1 reference

8 April 2019

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

platelet degranulation

1 reference

8 April 2019

negative regulation of megakaryocyte differentiation

TAS

1 reference

8 April 2019

Negative regulation of human megakaryocytopoiesis by human platelet factor 4 and beta thromboglobulin: comparative analysis in bone marrow cultures from normal individuals and patients ...

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

positive regulation of cAMP-mediated signaling

1 reference

1 January 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02776&geneProductId=UniProtKB:P02776

negative regulation of MHC class II biosynthetic process

1 reference

8 April 2019

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

2 references

response to lipopolysaccharide

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02776&geneProductId=UniProtKB:P02776

positive regulation of macrophage derived foam cell differentiation

1 reference

8 April 2019

Induction of dendritic cell-like phenotype in macrophages during foam cell formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

positive regulation of gene expression

1 reference

8 April 2019

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

regulation of cell population proliferation

1 reference

8 April 2019

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

positive regulation of tumor necrosis factor production

1 reference

8 April 2019

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

negative regulation of angiogenesis

1 reference

8 April 2019

Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

1 reference

8 April 2019

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

negative regulation of cytolysis

1 reference

8 April 2019

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

positive regulation of neutrophil chemotaxis

IEA

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02776&geneProductId=UniProtKB:P02776

antimicrobial humoral immune response mediated by antimicrobial peptide

1 reference

21 June 2018

Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02776&geneProductId=UniProtKB:P02776

regulation of megakaryocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

regulation of signaling receptor activity

TAS

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

adenylate cyclase-activating G protein-coupled receptor signaling pathway

IEA

1 reference

8 April 2019

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

TAS

neutrophil chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

8 April 2019

Platelet factor 4 is chemotactic for neutrophils and monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

antimicrobial humoral immune response mediated by antimicrobial peptide

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

cellular response to lipopolysaccharide

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02776

Chemokine interleukin-8-like domain

Gene Atlas image

PBB GE PF4 206390 x at fs.png
732 × 530; 8 KB

0 references

has part(s)

1 reference

CXC chemokine, conserved site

1 reference

CXC Chemokine domain

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

Identifiers

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016