Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions. (Q37407949)

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22 February 2020

title

Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions (English)

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22 February 2020

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2

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22 February 2020

7

Neil Osheroff

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22 February 2020

author name string

Katie J Aldred

1

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22 February 2020

Gangqin Li

3

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22 February 2020

Sylvia A McPherson

4

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22 February 2020

Charles L Turnbough

5

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22 February 2020

Robert J Kerns

6

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22 February 2020

publication date

30 September 2013

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22 February 2020

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22 February 2020

volume

8

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issue

12

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22 February 2020

page(s)

2660-2668

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Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance

22 February 2020

cites work

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Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

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Activities of different fluoroquinolones against Bacillus anthracis mutants selected in vitro and harboring topoisomerase mutations

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6 September 2017

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Type II topoisomerases as targets for quinolone antibacterials: turning Dr. Jekyll into Mr. Hyde

6 September 2017

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Mechanisms of action of antimicrobials: focus on fluoroquinolones

6 September 2017

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Mode of action of fluoroquinolones

6 September 2017

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Etoposide: four decades of development of a topoisomerase II inhibitor

6 September 2017

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Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage

6 September 2017

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DNA gyrase, topoisomerase IV, and the 4-quinolones

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Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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14 September 2017

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26 June 2018

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26 June 2018

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2 September 2018

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Interaction of divalent cations, quinolones and bacteria

2 September 2018

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12 December 2020

Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints

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12 December 2020

Increased sensitivity to quinolone antibacterials can be engineered in human topoisomerase IIα by selective mutagenesis

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12 December 2020

Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae

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12 December 2020

Clinical applications of anticancer drugs targeted to topoisomerase II

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12 December 2020

Clinical applications of quinolones

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12 December 2020

Identifiers

DOI

10.1021/CB400592N

1 reference

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22 February 2020

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22 February 2020

PubMed publication ID

24047414

1 reference