Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection. (Q37415419)

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scientific article published on October 2009

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English	Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection.	scientific article published on October 2009

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2 February 2020

Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection (English)

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2 February 2020

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2 February 2020

Edward J Lesnefsky

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Edward J Lesnefsky

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2 February 2020

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Mohammed Aldakkak

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James S Heisner

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Qun Chen

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Amadou K S Camara

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1 October 2009

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2 February 2020

Journal of Cardiovascular Pharmacology

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2 February 2020

298-309

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2 February 2020

Enhanced Na+/H+ exchange during ischemia and reperfusion impairs mitochondrial bioenergetics and myocardial function

1 reference

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6 September 2017

Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury

1 reference

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6 September 2017

Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence

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6 September 2017

New concepts in reactive oxygen species and cardiovascular reperfusion physiology

1 reference

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6 September 2017

Role of the cardiac Na+/H+ exchanger during ischemia and reperfusion

1 reference

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6 September 2017

Mechanisms and alternative methods of achieving cardiac arrest

1 reference

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6 September 2017

Reactive species mechanisms of cellular hypoxia-reoxygenation injury

1 reference

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6 September 2017

Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.

1 reference

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6 September 2017

Adenosine prevents hyperkalemia-induced calcium loading in cardiac cells: relevance for cardioplegia

1 reference

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6 September 2017

Increased work in cardiac trabeculae causes decreased mitochondrial NADH fluorescence followed by slow recovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

6 September 2017

Potassium channel openers prevent potassium-induced calcium loading of cardiac cells: possible implications in cardioplegia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

6 September 2017

Investigation of factors affecting fluorometric quantitation of cytosolic [Ca2+] in perfused hearts

1 reference

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6 September 2017

Effect of local anaesthetics on mitochondrial membrane potential in living cells

1 reference

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6 September 2017

Free radicals and their involvement during long-term myocardial ischemia and reperfusion

1 reference

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6 September 2017

The steady state TTX-sensitive ("window") sodium current in cardiac Purkinje fibres

1 reference

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6 September 2017

Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury

1 reference

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14 September 2017

Energy-linked regulation of glucose and pyruvate oxidation in isolated perfused rat heart. Role of pyruvate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

14 September 2017

Respiratory control in isolated perfused rat heart. Role of the equilibrium relations between the mitochondrial electron carriers and the adenylate system

1 reference

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14 September 2017

Optimal myocardial preservation: cooling, cardioplegia, and conditioning

1 reference

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28 September 2017

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

26 June 2018

Altered NADH and improved function by anesthetic and ischemic preconditioning in guinea pig intact hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

26 June 2018

Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics.

1 reference

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26 June 2018

Postischemic administration of succinate reverses the impairment of oxidative phosphorylation after cardiac ischemia and reperfusion injury.

1 reference

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26 June 2018

Lidocaine cardioplegia for prevention of reperfusion ventricular fibrillation.

1 reference

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26 June 2018

Blood cardioplegia delivery. Deleterious effects of potassium versus lidocaine.

1 reference

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26 June 2018

Multiple sites of inhibition of mitochondrial electron transport by local anesthetics.

1 reference

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26 June 2018

Uncoupling effects of local anesthetics on rat liver mitochondria.

1 reference

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26 June 2018

A comparative study of the effects of procaine, lidocaine, tetracaine and dibucaine on the functions and ultrastructure of isolated rat liver mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

26 June 2018

Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man

1 reference

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26 June 2018

Lidocaine: a hydroxyl radical scavenger and singlet oxygen quencher

1 reference

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26 June 2018

An isolated guinea pig heart preparation with in vivo like features

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26 June 2018

Lidocaine Effects on Brain Mitochondrial Metabolism in Vitro

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26 June 2018

Effects of tetracaine on displacement currents and contraction of frog skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

26 June 2018

The stabilizing effect of pyruvate on the function and metabolism of isolated perfused guinea pig hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

26 June 2018

The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat

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26 June 2018

Inhibited mitochondrial respiration by amobarbital during cardiac ischaemia improves redox state and reduces matrix Ca2+ overload and ROS release

1 reference

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2 September 2018

Adding bupivacaine to high-potassium cardioplegia improves function and reduces cellular damage of rat isolated hearts after prolonged, cold storage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria

1 reference

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2 September 2018

Improved mitochondrial bioenergetics by anesthetic preconditioning during and after 2 hours of 27 degrees C ischemia in isolated hearts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Inclusion of lidocaine in cardioplegic solutions provides additional myocardial protection.

1 reference

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2 September 2018

Warm ischemic preconditioning improves mitochondrial redox balance during and after mild hypothermic ischemia in guinea pig isolated hearts.

1 reference

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2 September 2018

Blockade of electron transport during ischemia protects cardiac mitochondria

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2 September 2018

Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation

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2 September 2018

Myocardial density and composition: a basis for calculating intracellular metabolite concentrations

1 reference

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2 September 2018

Hypothermia augments reactive oxygen species detected in the guinea pig isolated perfused heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Hydrolysis of Ca2+-sensitive fluorescent probes by perfused rat heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

How inotropic drugs alter dynamic and static indices of cyclic myoplasmic [Ca2+] to contractility relationships in intact hearts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Sevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Anesthetic preconditioning attenuates mitochondrial Ca2+ overload during ischemia in Guinea pig intact hearts: reversal by 5-hydroxydecanoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Ischemic preconditioning alters real-time measure of O2 radicals in intact hearts with ischemia and reperfusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Interaction of lidocaine with reactive oxygen and nitrogen species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Blocking Na(+)/H(+) exchange reduces [Na(+)](i) and [Ca(2+)](i) load after ischemia and improves function in intact hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Modulation of myocardial function and [Ca2+] sensitivity by moderate hypothermia in guinea pig isolated hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

NADH fluorescence in isolated guinea-pig and rat cardiomyocytes exposed to low or high stimulation rates and effect of metabolic inhibition with cyanide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Inhibitory effect of local anaesthetics on reactive oxygen species production by human neutrophils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Elective cardiac arrest with a hyperpolarizing adenosine triphosphate-sensitive potassium channel opener. A novel form of myocardial protection?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2774837

2 September 2018

Subcellular origin of the surface fluorescence of reduced nicotinamide nucleotides in the isolated perfused rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADH content and lactate production in the perfused rabbit heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ROS scavenging before 27 degrees C ischemia protects hearts and reduces mitochondrial ROS, Ca2+ overload, and changes in redox state

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at 26{degrees}C: comparison to ViaSpan solution

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial role in ischemia-reperfusion of rat hearts exposed to high-K+ cardioplegia and clonazepam: energetic and contractile consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-depolarizing cardioplegia activates Ca2+-ATPase in sarcoplasmic reticulum after reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced reactive O2 species formation and preserved mitochondrial NADH and [Ca2+] levels during short-term 17 degrees C ischemia in intact hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of hyperkalemic cardioplegia with altered [CaCl2] and [MgCl2] on [Ca2+]i transients and function after warm global ischemia in isolated hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial protection with cold, ischemic, potassium-induced cardioplegia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19620879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1097/FJC.0B013E3181B2B842

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2 February 2020

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2 February 2020

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2 February 2020

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