Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold (Q37417929)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24344247%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold (English)

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3 March 2020

2

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3 March 2020

Fan Yang

3

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3 March 2020

author name string

Xu Cao

1

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3 March 2020

Kewei Wang

4

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3 March 2020

Jie Zheng

5

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3 March 2020

publication date

16 December 2013

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The Journal of General Physiology

3 March 2020

published in

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3 March 2020

volume

143

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3 March 2020

issue

1

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3 March 2020

page(s)

75-90

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Divalent cations activate TRPV1 through promoting conformational change of the extracellular region

3 March 2020

cites work

1 reference

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Molecular mechanism of TRP channels

6 September 2017

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The role of allosteric coupling on thermal activation of thermo-TRP channels.

6 September 2017

1 reference

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TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids

6 September 2017

1 reference

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Distinct properties of Ca 2+ –calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

6 September 2017

1 reference

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Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations.

6 September 2017

1 reference

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A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels

6 September 2017

1 reference

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Localization of the PIP2 sensor of TRPV1 ion channels

6 September 2017

1 reference

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Kinetic and energetic analysis of thermally activated TRPV1 channels

6 September 2017

1 reference

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International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

6 September 2017

1 reference

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Thermosensitive TRP channel pore turret is part of the temperature activation pathway.

6 September 2017

1 reference

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Structure of TRPV1 channel revealed by electron cryomicroscopy

6 September 2017

1 reference

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Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin

6 September 2017

1 reference

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The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity

6 September 2017

1 reference

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Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors

6 September 2017

1 reference

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ThermoTRP channels as modular proteins with allosteric gating.

6 September 2017

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Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane.

6 September 2017

1 reference

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Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites

6 September 2017

1 reference

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Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8.

6 September 2017

1 reference

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TRP channels as cellular sensors

6 September 2017

1 reference

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Structural determinant of TRPV1 desensitization interacts with calmodulin

6 September 2017

1 reference

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Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels

6 September 2017

1 reference

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Mechanism of glutamate receptor desensitization

6 September 2017

1 reference

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Induction of vanilloid receptor channel activity by protein kinase C

6 September 2017

1 reference

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Acid potentiation of the capsaicin receptor determined by a key extracellular site

6 September 2017

1 reference

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Chemical and physiological characterization of fluo-4 Ca(2+)-indicator dyes

6 September 2017

1 reference

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Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+).

6 September 2017

1 reference

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Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+)

6 September 2017

1 reference

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The cloned capsaicin receptor integrates multiple pain-producing stimuli

6 September 2017

1 reference

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The capsaicin receptor: a heat-activated ion channel in the pain pathway

6 September 2017

1 reference

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An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding

6 September 2017

1 reference

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Biophysical and molecular mechanisms of Shaker potassium channel inactivation

6 September 2017

1 reference

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Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels

6 September 2017

1 reference

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Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

6 September 2017

1 reference

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Direct activation of transient receptor potential V1 by nickel ions

14 September 2017

1 reference

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Distinct modulations of human capsaicin receptor by protons and magnesium through different domains

14 September 2017

1 reference

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TRPV1 is activated by both acidic and basic pH.

14 September 2017

1 reference

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Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1.

14 September 2017

1 reference

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Voltage is a partial activator of rat thermosensitive TRP channels

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Dual regulation of TRPV1 by phosphoinositides.

14 September 2017

1 reference

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Polyamines are potent ligands for the capsaicin receptor TRPV1.

14 September 2017

1 reference

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Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage

14 September 2017

1 reference

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Biochemical characterization of the vanilloid receptor 1 expressed in a dorsal root ganglia derived cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Dynamic rearrangement of the outer mouth of a K+ channel during gating

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Use-dependent blockers and exit rate of the last ion from the multi-ion pore of a K+ channel

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores

26 June 2018

1 reference

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Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Calcium-dependent decrease in the single-channel conductance of TRPV1.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Structural determinants of gating in the TRPV1 channel.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Ionic interactions are essential for TRPV1 C-terminus binding to calmodulin

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Ca2+/calmodulin modulates TRPV1 activation by capsaicin.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Molecular basis for species-specific sensitivity to "hot" chili peppers

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Analysis of the native quaternary structure of vanilloid receptor 1.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

The variance of sodium current fluctuations at the node of Ranvier

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3874569

Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24344247

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24344247

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1085/JGP.201311025

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24344247%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24344247%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24344247%20AND%20SRC:MED&resulttype=core&format=json