Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use (Q37420857)

20 August 2017

Propylthiouracil (PTU) Hepatoxicity in Children and Recommendations for Discontinuation of Use (English)

1 reference

20 August 2017

Scott A Rivkees

1

1 reference

PMCID

2777303

20 August 2017

Donald R Mattison

series ordinal

2

1 reference

20 August 2017

21 April 2009

1 reference

International journal of pediatric endocrinology

20 August 2017

1 reference

20 August 2017

2009

1 reference

20 August 2017

132041

1 reference

https://scigraph.springernature.com/pub.10.1186/1687-9856-2009-132041

20 August 2017

0 references

cites work

Radioiodine treatment for pediatric Graves' disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Treatment outcome of Graves' disease in Thai children.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

The optimal treatment for pediatric Graves' disease is surgery

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

An optimal treatment for pediatric Graves' disease is radioiodine.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

The treatment of Graves' disease in children

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Fulminant hepatic failure associated with propylthiouracil: a case report with treatment emphasis on the use of plasmapheresis.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Successful outcome with methimazole and lithium combination therapy for propylthiouracil-induced hepatotoxicity.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Fulminant hepatic failure associated with propylthiouracil

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Methimazole-induced hepatotoxicity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Outcome of pediatric Graves' disease after treatment with antithyroid medication and radioiodine

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Clinical review 99: The management of Graves' disease in children, with special emphasis on radioiodine treatment

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Resolution of propylthiouracil-induced hepatic failure after treatment of thyrotoxicosis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil-induced hepatotoxicity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Unusual complications of antithyroid drug therapy: four case reports and review of literature

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil-induced hepatic failure and encephalopathy in a child

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

A case of methimazole-induced acute hepatic failure in a patient with chronic hepatitis B carrier

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil-associated hepatitis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Differences and Similarities in the Diagnosis and Treatment of Graves' Disease in Europe, Japan, and The United States

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Liver Disease Caused by Propylthiouracil

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil hepatotoxicity: two pediatric cases and review of the literature

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil and hepatitis. Two cases and a review of the literature

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Methimazole-associated cholestatic liver injury: case report and brief literature review.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil blocks extrathyroidal conversion of thyroxine to triiodothyronine and augments thyrotropin secretion in man.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil hepatotoxicity. A review and case presentation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Hepatotoxicity from propylthiouracil

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil-induced fulminant hepatitis: case report and review of the literature

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Liver transplantation for acute liver failure from drug induced liver injury in the United States

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Fifty years of experience with propylthiouracil-associated hepatotoxicity: what have we learned?

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil-induced hepatic damage

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Methimazole-induced cholestatic liver injury, mimicking sclerosing cholangitis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil-induced hepatic damage

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Malignant and benign neoplasms of the thyroid in patients treated for hyperthyroidism: a report of the cooperative thyrotoxicosis therapy follow-up study.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil-associated hepatitis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil-induced fatal hepatic necrosis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Hyperthyroidism in children treated with long term medical therapy: twenty-five percent remission every two years.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Propylthiouracil-induced cholestatic jaundice

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Management of hyperthyroidism in children and adolescents

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Hepatitis and Propylthiouracil

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Ending propylthiouracil-induced liver failure in children

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatment

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Clinical and economic outcomes of thyroid and parathyroid surgery in children.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Predicting the likelihood of remission in children with Graves' disease: a prospective, multicenter study

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Methimazole-induced cholestatic jaundice in an elderly hyperthyroid patient

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Methimazole embryopathy: a contribution to defining the phenotype.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Methimazole-induced cholestatic jaundice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Influence of iodine-131 dose on the outcome of hyperthyroidism in children.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Liver transplantation for propylthiouracil-induced acute hepatic failure

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Severe cholestatic jaundice in uncomplicated hyperthyroidism treated with methimazole

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Landmark perspective: Treatment of hyperthyroidism.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Landmark article May 8, 1943: Treatment of hyperthyroidism with thiourea and thiouracil. By E.B. Astwood.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Choanal atresia associated with maternal hyperthyroidism treated with methimazole: A case-control study

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Choanal atresia associated with prenatal methimazole exposure: Three new patients

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Treatment of Graves' Hyperthyroidism with Radioiodine: Results of a Prospective Randomized Study

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777303

Delayed cholestatic hepatitis due to methimazole

3 December 2018

1 reference

12 December 2020

Cholestasis induced hyperthyroidism after liver transplantation

1 reference

12 December 2020

Lactate Dehydrogenase(LDH)-Linked Immunoglobulin in a Patient with Graves' Disease Treated with Methimazole

1 reference

12 December 2020

Fatal propylthiouracil-induced hepatitis

1 reference

12 December 2020

Hepatitis associated with propylthiouracil treatment

1 reference

12 December 2020

Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization

1 reference

12 December 2020

Antithyroid drug-induced agranulocytosis: how has granulocyte colony-stimulating factor changed therapy?

1 reference

12 December 2020

Reduction in thyroid volume after radioiodine therapy of Graves' hyperthyroidism: results of a prospective, randomized, multicentre study

1 reference

12 December 2020

Surgical treatment of Graves' disease: subtotal or total thyroidectomy?

1 reference

12 December 2020

Agranulocytosis associated with antithyroid drugs. Effects of patient age and drug dose

1 reference

12 December 2020

Propylthiouracil and hepatitis: a case report

1 reference

12 December 2020

Propylthiouracil hepatotoxicity mimicking autoimmune chronic active hepatitis in a girl

1 reference

12 December 2020

Severe hepatotoxicity on beginning propylthiouracil therapy

1 reference

12 December 2020

Thyrotoxicosis in prepubertal children compared with pubertal and postpubertal patients

1 reference

12 December 2020

[Acquired sideroblastic anemia and cholestasis in a hyperthyroid patient treated with methimazole and atenolol]

1 reference

12 December 2020

Propylthiouracil-induced agranulocytosis, toxic hepatitis, and death

1 reference

12 December 2020

Thyroid nodules occurring late after treatment of thyrotoxicosis with radioiodine

1 reference

12 December 2020

Single daily dose of methimazole compared to every 8 hours propylthiouracil in the treatment of hyperthyroidism

1 reference

12 December 2020

An unusual presentation of fulminant hepatic failure secondary to propylthiouracil therapy

1 reference

12 December 2020

Correction. Propylthiouracil and hepatitis

1 reference

12 December 2020

Toxic manifestations of thiouracil therapy

1 reference

12 December 2020

Propylthiouracil-associated liver failure presenting as probable autoimmune hepatitis in a child with Graves' disease

1 reference

12 December 2020

Fulminant hepatitis during treatment with propylthiouracil

1 reference

12 December 2020

Graves' disease therapy in children: truth and inevitable consequences

1 reference

12 December 2020

Propylthiouracil-induced hepatotoxicity

1 reference

12 December 2020

10.1186/1687-9856-2009-132041

Identifiers

DOI

1 reference

PMCID

2777303

Dimensions Publication ID

20 August 2017

0 references

1 reference

20 August 2017

1 reference

PMCID

2777303