Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases (Q37421620)

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scientific article published on August 2006

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English	Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases	scientific article published on August 2006

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scholarly article

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28 December 2019

Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases (English)

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28 December 2019

Gavin P. Robertson

8

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28 December 2019

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Arati Sharma

1

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28 December 2019

Melissa A Tran

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28 December 2019

Shile Liang

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28 December 2019

Arun K Sharma

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28 December 2019

Shantu Amin

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28 December 2019

Charles D Smith

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28 December 2019

Cheng Dong

7

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28 December 2019

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1 August 2006

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28 December 2019

Cancer Research

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28 December 2019

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28 December 2019

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28 December 2019

8200-8209

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28 December 2019

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1 reference

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BRAF mutation predicts sensitivity to MEK inhibition

1 reference

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Oncogenic Ras in tumour progression and metastasis

1 reference

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Melanoma genetics and the development of rational therapeutics

1 reference

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The gene expression signatures of melanoma progression

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Distinct role of hydrodynamic shear in leukocyte-facilitated tumor cell extravasation

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Deregulated Akt3 activity promotes development of malignant melanoma

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23 August 2017

Stimulation of angiogenesis by Ras proteins

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Raf pathway inhibitors in oncology

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Mutations of the BRAF gene in benign and malignant melanocytic lesions

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BRAF as a potential therapeutic target in melanoma and other malignancies

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23 August 2017

Neutrophils influence melanoma adhesion and migration under flow conditions

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Apoptosis and melanoma chemoresistance

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Raf proteins and cancer: B-Raf is identified as a mutational target

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A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

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23 August 2017

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1 reference

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23 August 2017

Tumor angiogenesis and accessibility: role of vascular endothelial growth factor

1 reference

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23 August 2017

High frequency of BRAF mutations in nevi

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Design and discovery of small molecules targeting raf-1 kinase

1 reference

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23 August 2017

Mutations of the BRAF gene in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

23 August 2017

In vitro characterization and micromechanics of tumor cell chemotactic protrusion, locomotion, and extravasation

1 reference

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23 August 2017

Discovery of a novel Raf kinase inhibitor

1 reference

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1 reference

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1 reference

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1 reference

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V599EB-RAF is an oncogene in melanocytes

1 reference

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Treatment of metastatic melanoma with an orally available inhibitor of the Ras-Raf-MAPK cascade

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

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1 reference

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Neutrophil tethering on E-selectin activates beta 2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777627

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1 reference

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1 reference

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2 September 2018

BRAF as a melanoma susceptibility candidate gene?

1 reference

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Absence of exon 15 BRAF germline mutations in familial melanoma

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1 reference

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Selective anticancer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRAF and RAS mutations in human lung cancer and melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of PTEN promotes tumor development in malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exclusion of BRAFV599E as a melanoma susceptibility mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent Trends in Cutaneous Melanoma Incidence Among Whites in the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic BRAF is required for tumor growth and maintenance in melanoma models

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of BRAF(V599E) in human melanoma abrogates transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Method of mutation analysis may contribute to discrepancies in reports of (V599E)BRAF mutation frequencies in melanocytic neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16912199

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-06-0809

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28 December 2019

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28 December 2019

1 reference

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28 December 2019

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