LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction (Q37424610)

20 August 2017

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction (English)

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20 August 2017

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2 June 2020

Philip D Gregory

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J. Timothy Greenamyre

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Ole Isacson

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Fyodor D Urnov

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David E Paschon

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2 June 2020

author name string

Laurie H Sanders

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2 June 2020

Josée Laganière

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Sally K Mak

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B Joseph Vu

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Y Anne Huang

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2 June 2020

Malini Vangipuram

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Ramya Sundararajan

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J William Langston

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H Steve Zhang

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Birgitt Schüle

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2 June 2020

publication date

19 October 2013

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20 August 2017

Neurobiology of Disease

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2 June 2020

volume

62

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2 June 2020

page(s)

381-386

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Oxidative damage to macromolecules in human Parkinson disease and the rotenone model

2 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Genome-wide association study reveals genetic risk underlying Parkinson's disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Instability and decay of the primary structure of DNA

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Genomic damage and its repair in young and aging brain

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3877733

Analysis of gene-specific DNA damage and repair using quantitative polymerase chain reaction

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24148854

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Oxidative damage in Parkinson's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24148854

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24148854

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NBD.2013.10.013

1 reference

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2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24148854%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

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