Type 1 diabetes development requires both CD4+ and CD8+ T cells and can be reversed by non-depleting antibodies targeting both T cell populations. (Q37425120)

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scientific article published on 10 August 2009

Language	Label	Description	Also known as
English	Type 1 diabetes development requires both CD4+ and CD8+ T cells and can be reversed by non-depleting antibodies targeting both T cell populations.	scientific article published on 10 August 2009

Statements

scholarly article

1 reference

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9 February 2020

Type 1 diabetes development requires both CD4+ and CD8+ T cells and can be reversed by non-depleting antibodies targeting both T cell populations (English)

1 reference

Europe PubMed Central

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9 February 2020

type-1 diabetes

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3

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9 February 2020

author name string

Jenny M Phillips

1

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9 February 2020

Nicole M Parish

2

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9 February 2020

Chris Bland

4

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9 February 2020

Yvonne Sawyer

5

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9 February 2020

Hugo De La Peña

6

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9 February 2020

Anne Cooke

7

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9 February 2020

publication date

10 August 2009

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9 February 2020

The review of diabetic studies : RDS

1 reference

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9 February 2020

6

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9 February 2020

2

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9 February 2020

97-103

1 reference

Europe PubMed Central

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9 February 2020

Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

23 August 2017

Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

23 August 2017

Transgenic rescue implicates beta2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

23 August 2017

Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

23 August 2017

Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

23 August 2017

CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

23 August 2017

Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

23 August 2017

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

23 August 2017

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

23 August 2017

"Infectious" transplantation tolerance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

23 August 2017

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

14 September 2017

The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti-CD4 and anti-CD8 antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

26 June 2018

Induction of tolerance in peripheral T cells with monoclonal antibodies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

26 June 2018

Cytotoxic T cell mechanisms of beta cell destruction in non-obese diabetic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

2 September 2018

Patients with chronic pancreatitis have islet progenitor cells in their ducts, but reversal of overt diabetes in NOD mice by anti-CD3 shows no evidence for islet regeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

2 September 2018

Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

2 September 2018

Tolerogenic strategies to halt or prevent type 1 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

2 September 2018

MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

2 September 2018

Analysis of the roles of CD4+ and CD8+ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779016

2 September 2018

CD8 T cells are not required for islet destruction induced by a CD4+ islet-specific T-cell clone

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The involvement of Ly 2+ T cells in beta cell destruction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Administration of silica particles or anti-Lyt2 antibody prevents beta-cell destruction in NOD mice given cyclophosphamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transfer of autoimmune diabetes in NOD mice can be inhibited or accelerated by distinct cell populations present in normal splenocytes taken from young males

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymus-dependent monoclonal antibody-induced protection from transferred diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19806239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1900/RDS.2009.6.97

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19806239%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19806239%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19806239%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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