CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants (Q37427587)

20 August 2017

CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants (English)

1 reference

20 August 2017

3

Robert F Siliciano

1 reference

20 August 2017

4

Joel N Blankson

1 reference

20 August 2017

2

Robert W Buckheit

1 reference

20 August 2017

Christopher W Pohlmeyer

series ordinal

1

1 reference

PMCID

3878989

20 August 2017

language of work or name

1 reference

12 December 2013

1 reference

20 August 2017

1 reference

20 August 2017

10

1 reference

20 August 2017

152

1 reference

Creative Commons Attribution 2.0 Generic

20 August 2017

start time

1 December 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

exact match

https://scigraph.springernature.com/pub.10.1186/1742-4690-10-152

0 references

cites work

Gag-positive reservoir cells are susceptible to HIV-specific cytotoxic T lymphocyte mediated clearance in vitro and can be detected in vivo [corrected]

1 reference

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A novel PCR assay for quantification of HIV-1 RNA.

23 August 2017

1 reference

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Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cells

23 August 2017

1 reference

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Inhibitory potential of subpopulations of CD8+ T cells in HIV-1-infected elite suppressors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Escape from CD8(+) T cell responses in Mamu-B*00801(+) macaques differentiates progressors from elite controllers

23 August 2017

1 reference

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Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor

23 August 2017

1 reference

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Epidemiology and clinical characteristics of elite controllers

23 August 2017

1 reference

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The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

23 August 2017

1 reference

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Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control

23 August 2017

1 reference

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Elucidating the elite: mechanisms of control in HIV-1 infection

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses

23 August 2017

1 reference

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The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

23 August 2017

1 reference

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Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients

23 August 2017

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Epidemiologic characteristics and natural history of HIV-1 natural viral suppressors

23 August 2017

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Reduced viral replication capacity of human immunodeficiency virus type 1 subtype C caused by cytotoxic-T-lymphocyte escape mutations in HLA-B57 epitopes of capsid protein

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control

23 August 2017

1 reference

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Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study

23 August 2017

1 reference

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Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control

23 August 2017

1 reference

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HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.

23 August 2017

1 reference

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Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressor

23 August 2017

1 reference

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HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control

23 August 2017

1 reference

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Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.

23 August 2017

1 reference

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A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells

23 August 2017

1 reference

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Recognition of escape variants in ELISPOT does not always predict CD8+ T-cell recognition of simian immunodeficiency virus-infected cells expressing the same variant sequences

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication

23 August 2017

1 reference

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A whole-genome association study of major determinants for host control of HIV-1

23 August 2017

1 reference

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Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression

23 August 2017

1 reference

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The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations

23 August 2017

1 reference

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Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control

23 August 2017

1 reference

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

23 August 2017

1 reference

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De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection

23 August 2017

1 reference

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HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replication

23 August 2017

1 reference

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Rapid viral escape at an immunodominant simian-human immunodeficiency virus cytotoxic T-lymphocyte epitope exacts a dramatic fitness cost

23 August 2017

1 reference

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Fitness costs limit viral escape from cytotoxic T lymphocytes at a structurally constrained epitope

23 August 2017

1 reference

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Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial

23 August 2017

1 reference

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Novel single-cell-level phenotypic assay for residual drug susceptibility and reduced replication capacity of drug-resistant human immunodeficiency virus type 1.

23 August 2017

1 reference

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The differential ability of HLA B*5701+ long-term nonprogressors and progressors to restrict human immunodeficiency virus replication is not caused by loss of recognition of autologous viral gag sequences

23 August 2017

1 reference

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Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.

23 August 2017

1 reference

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Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection

23 August 2017

1 reference

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Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection

23 August 2017

1 reference

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Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection

23 August 2017

1 reference

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HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

23 August 2017

1 reference

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Switch from perforin-expressing to perforin-deficient CD8(+) T cells accounts for two distinct types of effector cytotoxic T lymphocytes in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

MHC-I-restricted presentation of HIV-1 virion antigens without viral replication

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

HIV-1 Gag evolution in recently infected human leukocyte antigen-B*57 patients with low-level viremia.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

HLA-B35 is associated with accelerated progression to AIDS.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Primary CD8+ T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4+ T cells

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Long-term nonprogressive disease among untreated HIV-infected individuals: clinical implications of understanding immune control of HIV.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressors

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Evolution of HIV-1 in an HLA-B*57-positive patient during virologic escape.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Reversion of CTL escape–variant immunodeficiency viruses in vivo

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Genomewide Association Study of an AIDS‐Nonprogression Cohort Emphasizes the Role Played byHLAGenes (ANRS Genomewide Association Study 02)

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3878989

Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)

3 December 2018

1 reference

12 December 2020

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

1 reference

12 December 2020

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes

1 reference

12 December 2020

Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection

1 reference

12 December 2020

Identifiers

DOI

10.1186/1742-4690-10-152

1 reference

PMCID

3878989

Dimensions Publication ID

20 August 2017

0 references

1 reference

20 August 2017

1 reference

PMCID

3878989