Application of fixed exponent 0.75 to the prediction of human drug clearance: an inaccurate and misleading concept (Q37437579)

20 August 2017

Application of fixed exponent 0.75 to the prediction of human drug clearance: an inaccurate and misleading concept (English)

1 reference

20 August 2017

Iftekhar Mahmood

1

1 reference

20 August 2017

1 January 2009

1 reference

Drug Metabolism and Drug Interactions

20 August 2017

1 reference

20 August 2017

24

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20 August 2017

1

1 reference

20 August 2017

57-81

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Energy metabolism and body size. II. Dimensional analysis and energetic non-similarity

20 August 2017

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

The 3/4 mass exponent for energy metabolism is not a statistical artifact.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Basal metabolic rates in mammals: taxonomic differences in the allometry of BMR and body mass.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Design of the mammalian respiratory system. III. Scaling maximum aerobic capacity to body mass: Wild and domestic mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Relationships among liver and kidney volumes, lean body mass and drug clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Beyond the '3/4-power law': variation in the intra- and interspecific scaling of metabolic rate in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Allometric exponents do not support a universal metabolic allometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Prediction of drug clearance in children from adults: a comparison of several allometric methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Prediction of drug clearance in children: impact of allometric exponents, body weight, and age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Interspecies scaling: predicting clearance of drugs in humans. Three different approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Interspecies scaling of cimetidine-theophylline pharmacokinetic interaction: interspecies scaling in pharmacokinetic interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Interspecies metabolism and pharmacokinetic scaling of theophylline disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Expression of the Human CYP3A4 Gene in the Small Intestine of Transgenic Mice: In Vitro Metabolism and Pharmacokinetics of Midazolam

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Effect of multiple dosing of ketoconazole on pharmacokinetics of midazolam, a cytochrome P-450 3A substrate in beagle dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Pharmacokinetics of the newer benzodiazepines

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Clinical pharmacokinetics of troglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

The pharmacokinetics and organ distribution of ajmaline and quindine in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Pharmacokinetics of a novel antiarrhythmic drug, actisomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Clinical pharmacokinetics of tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Prediction of brain delivery of ofloxacin, a new quinolone, in the human from animal data

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Animal pharmacokinetics and interspecies scaling of FCE 22101, a penem antibiotic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Pharmacokinetics and tolerance of a new penem antibiotic, FCE 22101, in healthy volunteers after a single intravenous dose

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

In vitro and in vivo metabolism of a potent and selective integrin alpha v beta 3 antagonist in rats, dogs, and monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

Interspecies pharmacokinetic comparisons and allometric scaling of napsagatran, a low molecular weight thrombin inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FDMDI.2009.24.1.57

10.1515/DMDI.2009.24.1.57

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19354001