High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells. (Q37441219)

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scientific article published on September 2009

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English	High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells.	scientific article published on September 2009

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6 February 2020

High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells (English)

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6 February 2020

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6 February 2020

Gilberto Fronza

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Paola Menichini

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Laura Ottaggio

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Alberto Inga

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Prema Iyer

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Barry Gold

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1 September 2009

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Mutation Research

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6 February 2020

1-2

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6 February 2020

Eukaryotic Y-family polymerases bypass a 3-methyl-2'-deoxyadenosine analog in vitro and methyl methanesulfonate-induced DNA damage in vivo

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Mutational specificity and genetic control of replicative bypass of an abasic site in yeast

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23 August 2017

Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent.

1 reference

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Base excision repair intermediates are mutagenic in mammalian cells

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23 August 2017

The biological effects of N3-methyladenine

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A phase I study of bizelesin, a highly potent and selective DNA-interactive agent, in patients with advanced solid malignancies

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HPRT mutations in humans: biomarkers for mechanistic studies

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Alu repeats and human disease

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23 August 2017

Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11.

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Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing

1 reference

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Rate of depurination of native deoxyribonucleic acid

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23 August 2017

HPRT: gene structure, expression, and mutation

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23 August 2017

Automated DNA sequencing of the human HPRT locus

1 reference

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Human glioma cell sensitivity to the sequence-specific alkylating agent methyl-lexitropsin

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14 September 2017

A recurrent large Alu-mediated deletion in the hypoxanthine phosphoribosyltransferase (HPRT1) gene associated with Lesch-Nyhan syndrome.

1 reference

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28 September 2017

A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome

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A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography.

1 reference

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26 June 2018

Duplication in the hypoxanthine phosphoribosyl-transferase gene caused by Alu-Alu recombination in a patient with Lesch Nyhan syndrome

1 reference

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26 June 2018

Analysis of 4-nitroquinoline-1-oxide induced mutations at the hprt locus in mammalian cells: possible involvement of preferential DNA repair

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26 June 2018

The Chinese hamster HPRT gene: restriction map, sequence analysis, and multiplex PCR deletion screen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

26 June 2018

Strand-specific mutation spectra in repair-proficient and repair-deficient hamster cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

26 June 2018

Nucleotide excision repair defect influences lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent in the absence of base excision repair

1 reference

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2 September 2018

DNA damage and cytotoxicity induced by minor groove binding methyl sulfonate esters

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2 September 2018

Influences of base excision repair defects on the lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783936

2 September 2018

Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester

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2 September 2018

Evidence in Escherichia coli that N3-methyladenine lesions induced by a minor groove binding methyl sulfonate ester can be processed by both base and nucleotide excision repair

1 reference

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Cytotoxic and clastogenic effects of a DNA minor groove binding methyl sulfonate ester in mismatch repair deficient leukemic cells.

1 reference

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2 September 2018

Repair in Escherichia coli alkB mutants of abasic sites and 3-methyladenine residues in DNA.

1 reference

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2 September 2018

Molecular nature of spontaneous mutations at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus in Chinese hamster ovary cells

1 reference

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Groove- and sequence-selective alkylation of DNA by sulfonate esters tethered to lexitropsins

1 reference

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Multiplex DNA amplification and solid-phase direct sequencing for mutation analysis at the hprt locus in Chinese hamster cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The in vitro methylation of DNA by a minor groove binding methyl sulfonate ester

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of two deletion events involving Alu-sequences, one novel base substitution and two tentative hotspot mutations in the hypoxanthine phosphoribosyltransferase (HPRT) gene in five patients with Lesch-Nyhan syndrome

1 reference

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12 December 2020

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Mutations that alter RNA splicing of the human HPRT gene: a review of the spectrum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

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Modulation of the toxic and mutagenic effects induced by methyl methanesulfonate in Chinese hamster ovary cells by overexpression of the rat N-alkylpurine-DNA glycosylase

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Relationship between DNA methylation and mutational patterns induced by a sequence selective minor groove methylating agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

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Mutations induced by X-rays at the HPRT locus in cultured Chinese hamster cells are mostly large deletions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

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Nucleotide sequence determination of point mutations at the mouse HPRT locus using in vitro amplification of HPRT mRNA sequences

1 reference

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based on heuristic

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19729030

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MRFMMM.2009.08.013

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6 February 2020

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6 February 2020

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6 February 2020

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