iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. (Q37447788)

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scientific article published on 02 September 2009

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English	iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.	scientific article published on 02 September 2009

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6 February 2020

iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase (English)

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Hyphessobrycon rosaceus

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Streptomyces platensis

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Streptomyces coelicolor

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Streptomyces albus

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Streptomyces lividans

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Streptomyces albidoflavus

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Streptomyces avermitilis

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Iso-migrastatin

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4-[(5S)-5-[(3Z,5R,6S,7S,8E,12E)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxo-1-oxacyclotetradeca-3,8,12-trien-2-yl]-4-oxohexyl]piperidine-2,6-dione

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Si-Kyu Lim

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Jianhua Ju

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Emmanuel Zazopoulos

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Hui Jiang

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Jeong-Woo Seo

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Yihua Chen

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Zhiyang Feng

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Scott R Rajski

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Ben Shen

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29746-29756

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Type I polyketide synthases that require discrete acyltransferases

1 reference

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Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.

1 reference

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