Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro (Q37464829)

20 August 2017

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title

Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro (English)

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20 August 2017

Katharina Zimmermann

3

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Peter W. Reeh

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Peter W Reeh

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2

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author name string

Michael St Pierre

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1

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20 August 2017

30 April 2009

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Experimental Brain Research

20 August 2017

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20 August 2017

196

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20 August 2017

1

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20 August 2017

31-44

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https://scigraph.springernature.com/pub.10.1007/s00221-009-1808-3

20 August 2017

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Heat-evoked activation of the ion channel, TRPV4.

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Background potassium channel block and TRPV1 activation contribute to proton depolarization of sensory neurons from humans with neuropathic pain

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Capsaicin desensitization of peripheral nociceptive fibres does not impair sensitivity to other noxious stimuli

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TRPV3 is a calcium-permeable temperature-sensitive cation channel.

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A receptor for protons in the nerve cell membrane

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Selective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin.

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A heat-sensitive TRP channel expressed in keratinocytes

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Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurons from newborn rats.

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Impaired nociception and pain sensation in mice lacking the capsaicin receptor

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Activation of primary afferent neurons by thermal stimulation. Influence of ruthenium red

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Effects of TRPV1 receptor antagonists on stimulated iCGRP release from isolated skin of rats and TRPV1 mutant mice

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The TRPV1/2/3 activator 2-aminoethoxydiphenyl borate sensitizes native nociceptive neurons to heat in wildtype but not TRPV1 deficient mice

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Low-threshold heat response antagonized by capsazepine in chick sensory neurons, which are capsaicin-insensitive

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Nociceptors Lacking TRPV1 and TRPV2 Have Normal Heat Responses

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12 December 2020

Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro

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12 December 2020

Ruthenium red blocks the capsaicin-induced increase in intracellular calcium and activation of membrane currents in sensory neurones as well as the activation of peripheral nociceptors in vitro.

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12 December 2020

Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin.

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12 December 2020

Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli

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12 December 2020

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12 December 2020

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Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures

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Why cooling is beneficial: non-linear temperature-dependency of stimulated iCGRP release from isolated rat skin

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12 December 2020

Proton-induced calcitonin gene-related peptide release from rat sciatic nerve axons, in vitro, involving TRPV1.

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Characterization of neurons responsive to noxious colorectal distension in the T13-L2 spinal cord of the rat

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Block by ruthenium red of cloned neuronal voltage-gated calcium channels.

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12 December 2020

10.1007/S00221-009-1808-3

Identifiers

DOI

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20 August 2017

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PubMed ID

19404626