Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds. (Q37485056)

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scientific article published on 03 January 2014

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English	Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.	scientific article published on 03 January 2014

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4 March 2020

Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds (English)

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4 March 2020

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Richard J Sciotti

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4 March 2020

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Diana Caridha

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4 March 2020

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Sean R Marcsisin

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Jason C Sousa

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Gregory A Reichard

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Qiang Zeng

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Norma Roncal

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Ronan McNulty

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Julio Careagabarja

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Jason W Bennett

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Victor E Zottig

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Gregory Deye

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4 March 2020

Qigui Li

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Lisa Read

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4 March 2020

N P Dhammika Nanayakkara

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4 March 2020

Larry A Walker

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4 March 2020

Bryan Smith

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Victor Melendez

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Brandon S Pybus

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4 March 2020

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3 January 2014

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4 March 2020

Malaria Journal

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4 March 2020

2

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4 March 2020

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

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23 August 2017

Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria

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23 August 2017

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

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23 August 2017

Optimising strategies for Plasmodium falciparum malaria elimination in Cambodia: primaquine, mass drug administration and artemisinin resistance

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23 August 2017

Use of CYP2D6 genotyping in practice: tamoxifen dose adjustment

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23 August 2017

The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites

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23 August 2017

Primaquine in vivax malaria: an update and review on management issues

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23 August 2017

Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta)

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23 August 2017

Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.

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23 August 2017

The efficacy and tolerability of three different regimens of tafenoquine versus primaquine for post-exposure prophylaxis of Plasmodium vivax malaria in the Southwest Pacific

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23 August 2017

Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S. population: clinical implications

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23 August 2017

Primaquine therapy for malaria

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23 August 2017

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

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23 August 2017

Cytochromes P450 and metabolism of xenobiotics

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23 August 2017

An LC-MS based study of the metabolic profile of primaquine, an 8-aminoquinoline antiparasitic drug, with an in vitro primary human hepatocyte culture model

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6 September 2017

Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines

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6 September 2017

Gametocytocidal and sporontocidal effects of primaquine upon two strains of Plasmodium falciparum

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6 September 2017

Randomized trial of 3-dose regimens of tafenoquine (WR238605) versus low-dose primaquine for preventing Plasmodium vivax malaria relapse

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26 June 2018

Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in Thailand

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26 June 2018

Primaquine failure and cytochrome P-450 2D6 in Plasmodium vivax malaria

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2 September 2018

Recurrent Plasmodium vivax malaria due to dose-dependent primaquine resistance: a case report

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2 September 2018

Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes.

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2 September 2018

In vitro activity of tafenoquine against the asexual blood stages of Plasmodium falciparum isolates from Gabon, Senegal, and Djibouti

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Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles

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2 September 2018

Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant P. falciparum malaria

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2 September 2018

A randomized, double-blind, placebo-controlled, dose-ranging trial of tafenoquine for weekly prophylaxis against Plasmodium falciparum

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2 September 2018

Human CYP2D6 and mouse CYP2Ds: organ distribution in a humanized mouse model

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12 December 2020

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Hydroxyl radical formation as a result of the interaction between primaquine and reduced pyridine nucleotides. Catalysis by hemoglobin and microsomes

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct ESR detection of a free radical intermediate during the peroxidase-catalyzed oxidation of the antimalarial drug primaquine

1 reference

https://pubmed.ncbi.nlm.nih.gov/24386891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxylated metabolites of the antimalarial drug primaquine. Oxidation and redox cycling

1 reference

https://pubmed.ncbi.nlm.nih.gov/24386891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxidation of the antimalarial drug primaquine: characterization of a benzidine-like metabolite with methaemoglobin-forming activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24386891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative activity of primaquine metabolites on rat erythrocytes in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24386891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of primaquine by liver homogenate fractions. Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to carboxyprimaquine

1 reference

https://pubmed.ncbi.nlm.nih.gov/24386891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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4 March 2020

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4 March 2020

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