Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees? (Q37492248)

20 August 2017

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title

Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees? (English)

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20 August 2017

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ChEBI release 2020-05-28

4

Gerhard Opelz

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20 August 2017

3

Hans-Georg Rammensee

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20 August 2017

Stefan Löb

1

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20 August 2017

Alfred Königsrainer

series ordinal

2

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20 August 2017

Peter Terness

series ordinal

5

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20 August 2017

language of work or name

English

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publication date

1 June 2009

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20 August 2017

Nature Reviews Cancer

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20 August 2017

9

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20 August 2017

445-452

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20 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrc2639

20 August 2017

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cites work

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31 March 2020

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Induction of pulmonary indoleamine 2,3-dioxygenase by intraperitoneal injection of bacterial lipopolysaccharide

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Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection

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Immunosuppressive networks in the tumour environment and their therapeutic relevance

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Inhibition of T cell proliferation by macrophage tryptophan catabolism

31 March 2020

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Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division

31 March 2020

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GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

31 March 2020

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Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase.

31 March 2020

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Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites

31 March 2020

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T cell apoptosis by kynurenines.

31 March 2020

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The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation

31 March 2020

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3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis

31 March 2020

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Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

31 March 2020

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Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.

31 March 2020

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Immune escape as a fundamental trait of cancer: focus on IDO.

31 March 2020

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Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression

31 March 2020

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Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity

31 March 2020

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Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma

31 March 2020

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Bin1 ablation increases susceptibility to cancer during aging, particularly lung cancer.

31 March 2020

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Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma.

31 March 2020

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A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation

31 March 2020

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Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells.

31 March 2020

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Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion.

31 March 2020

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Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

31 March 2020

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Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)-producing dendritic cells: too much ado about IDO?

31 March 2020

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The immunoregulatory role of IDO-producing human dendritic cells revisited.

31 March 2020

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Are indoleamine-2,3-dioxygenase producing human dendritic cells a tool for suppression of allogeneic T-cell responses?

31 March 2020

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Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma.

31 March 2020

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Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes.

31 March 2020

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IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism

31 March 2020

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Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells.

31 March 2020

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Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma

31 March 2020

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Immunoactivative role of indoleamine 2,3-dioxygenase in human hepatocellular carcinoma

31 March 2020

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Expression of indoleamine 2,3-dioxygenase in tumor endothelial cells correlates with long-term survival of patients with renal cell carcinoma

31 March 2020

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Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients

31 March 2020

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Neopterin as an indicator of immune activation and prognosis in patients with gynecological malignancies

31 March 2020

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Neopterin as a prognostic parameter in patients with squamous-cell carcinomas of the oral cavity

31 March 2020

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Neopterin: a prognostic variable in operations for lung cancer

31 March 2020

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Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients

31 March 2020

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The molecular cell biology of interferon-gamma and its receptor

31 March 2020

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Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma

31 March 2020

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Molecular mechanisms underlying IFN-gamma-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12

31 March 2020

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Antitumor and antimetastatic activity of interleukin 12 against murine tumors

31 March 2020

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Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cells

31 March 2020

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Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection.

31 March 2020

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Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses

31 March 2020

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Interferon-gamma in the first-line therapy of ovarian cancer: a randomized phase III trial

31 March 2020

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A Toll-like receptor recognizes bacterial DNA

31 March 2020

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Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells

31 March 2020

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Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909.

31 March 2020

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Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signaling

31 March 2020

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Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO.

31 March 2020

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Toll-like receptor 9-mediated induction of the immunosuppressive pathway of tryptophan catabolism.

31 March 2020

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4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms

31 March 2020

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Anti-CD137 antibodies in the treatment of autoimmune disease and cancer

31 March 2020

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4-1BB-mediated immunotherapy of rheumatoid arthritis.

31 March 2020

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NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies.

31 March 2020

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Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

31 March 2020

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The therapeutic potential of 4-1BB (CD137) in cancer.

31 March 2020

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Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific

31 March 2020

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Induction of tryptophan 2,3-dioxygenase in the mouse endometrium during implantation

31 March 2020

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Quantitative and spatial differences in the expression of tryptophan-metabolizing enzymes in mouse epididymis.

31 March 2020

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Identification of tryptophan 2,3-dioxygenase RNA in rodent brain.

31 March 2020

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Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice

31 March 2020

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Evolution of vertebrate indoleamine 2,3-dioxygenases

31 March 2020

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Discrimination between D- and L-tyrosyl transfer ribonucleic acids in peptide chain elongation

31 March 2020

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1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase

31 March 2020

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Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan

31 March 2020

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Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice

31 March 2020

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Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells

31 March 2020

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Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape.

31 March 2020

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1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity

31 March 2020

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Taking dendritic cells into medicine

31 March 2020

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Characterisation of L-tryptophan transporters in human placenta: a comparison of brush border and basal membrane vesicles

31 March 2020

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Transcriptional regulation of indoleamine 2,3-dioxygenase (IDO) by tryptophan and its analogue : Down-regulation of the indoleamine 2,3-dioxygenase (IDO) transcription by tryptophan and its analogue.

31 March 2020

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Nucleic acids as therapeutic agents

31 March 2020

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31 March 2020

MicroRNAs and cancer.

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Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applications

31 March 2020

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RNA interference: ready to silence cancer?

31 March 2020

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Bcl-2-targeted antisense therapy (Oblimersen sodium): towards clinical reality

31 March 2020

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Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference

31 March 2020

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(-)-Epigallocatechin gallate suppresses indoleamine 2,3-dioxygenase expression in murine dendritic cells: evidences for the COX-2 and STAT1 as potential targets.

31 March 2020

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Rosmarinic acid inhibits indoleamine 2,3-dioxygenase expression in murine dendritic cells

31 March 2020

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p-Coumaric acid inhibits indoleamine 2, 3-dioxygenase expression in murine dendritic cells

31 March 2020

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Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage.

31 March 2020

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Botanicals in cancer chemoprevention

31 March 2020

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A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase.

31 March 2020

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Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors.

31 March 2020

1 reference

Exiguamine A, an indoleamine-2,3-dioxygenase (IDO) inhibitor isolated from the marine sponge Neopetrosia exigua

31 March 2020

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Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A.

31 March 2020

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Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase

31 March 2020

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Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.

31 March 2020

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Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase

31 March 2020

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Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques

31 March 2020

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Apoptosis induced by nicotinamide-related compounds and quinolinic acid in HL-60 cells

31 March 2020

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A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation

31 March 2020

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Bimodal effect of nitric oxide in the enzymatic activity of indoleamine 2,3-dioxygenase in human monocytic cells

31 March 2020

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Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells.

31 March 2020

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How embryos may avoid immune attack

31 March 2020

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Exploring the mechanism of tryptophan 2,3-dioxygenase

31 March 2020

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Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis

31 March 2020

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Expression of indoleamine 2,3-dioxygenase (IDO) by endothelial cells: implications for the control of alloresponses

31 March 2020

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Inhibition of Chlamydia pneumoniae replication in human aortic smooth muscle cells by gamma interferon-induced indoleamine 2, 3-dioxygenase activity

31 March 2020

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Role of IDO activation in anti-microbial defense in human native astrocytes.

31 March 2020

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The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function

31 March 2020

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Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation

31 March 2020

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Modulation of tryptophan catabolism by regulatory T cells.

31 March 2020

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CTLA-4-Ig regulates tryptophan catabolism in vivo.

31 March 2020

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Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy

31 March 2020

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CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86.

31 March 2020

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The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells

31 March 2020

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Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase

31 March 2020

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Interferon-gamma-modified dendritic cells suppress B cell function and ameliorate the development of experimental autoimmune myasthenia gravis

31 March 2020

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Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer

31 March 2020

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Expression of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase in early concepti

31 March 2020

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12 December 2020

The immunomodulating effect of interferon-gamma intravesical instillations in preventing bladder cancer recurrence.

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12 December 2020

Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation.

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12 December 2020

Increased neopterin concentrations in patients with cancer: indicator of oxidative stress?

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12 December 2020

Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity.

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12 December 2020

Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells.

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12 December 2020

Tryptophan degradation in transplanted tumor cells undergoing rejection

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12 December 2020

Increased synthesis of indoleamine-2,3-dioxygenase protein is positively associated with impaired survival in patients with serous-type, but not with other types of, ovarian cancer

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12 December 2020

Tryptophan pyrrole ring cleavage enzymes in placenta

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12 December 2020

The conversion of tryptophan to kynurenine in liver. I. The coupled tryptophan peroxidase-oxidase system forming formylkynurenine

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12 December 2020

Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells

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12 December 2020

Tryptophan pyrrolase of rabbit intestine. D- and L-tryptophan-cleaving enzyme or enzymes.

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12 December 2020

Expression of a MYCN-interacting isoform of the tumor suppressor BIN1 is reduced in neuroblastomas with unfavorable biological features.

1 reference

12 December 2020

Neopterin is an independent prognostic variable in females with breast cancer

1 reference

12 December 2020

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production

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12 December 2020

Identifiers

DOI

10.1038/NRC2639

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Dimensions Publication ID

20 August 2017

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