Ewing's sarcoma: standard and experimental treatment options (Q37522056)

20 August 2017

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title

Ewing's sarcoma: standard and experimental treatment options (English)

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20 August 2017

Alexander J Lazar

3

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author name string

Vivek Subbiah

1

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20 August 2017

Pete Anderson

2

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20 August 2017

Emily Burdett

4

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20 August 2017

Kevin Raymond

5

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20 August 2017

Joseph A Ludwig

6

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20 August 2017

publication date

1 April 2009

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Current Treatment Options in Oncology

20 August 2017

published in

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20 August 2017

volume

10

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20 August 2017

issue

1-2

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20 August 2017

page(s)

126-140

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Long-term clinical and functional outcomes after treatment for localized Ewing's tumor of the lower extremity.

20 August 2017

cites work

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21 January 2018

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Microarray analysis of Ewing's sarcoma family of tumours reveals characteristic gene expression signatures associated with metastasis and resistance to chemotherapy

21 January 2018

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Extraskeletal neoplasm resembling Ewing's sarcoma

21 January 2018

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12 December 2020

Temozolomide and intravenous irinotecan for treatment of advanced Ewing sarcoma

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12 December 2020

Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides

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12 December 2020

Adjuvant and neoadjuvant chemotherapy for Ewing sarcoma family tumors in patients aged between 40 and 60: report of 35 cases and comparison of results with 586 younger patients treated with the same protocols in the same years

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12 December 2020

Definitive radiotherapy for ewing tumors of extremities and pelvis: long-term disease control, limb function, and treatment toxicity

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12 December 2020

Allogeneic and autologous stem-cell transplantation in advanced Ewing tumors. An update after long-term follow-up from two centers of the European Intergroup study EICESS. Stem-Cell Transplant Programs at Düsseldorf University Medical Center, German

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Suppression of Ewing's sarcoma tumor growth, tumor vessel formation, and vasculogenesis following anti vascular endothelial growth factor receptor-2 therapy

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12 December 2020

Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases

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12 December 2020

Wnt/Frizzled signaling in Ewing sarcoma

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12 December 2020

Intergroup Ewing's Sarcoma Study: local control related to radiation dose, volume, and site of primary lesion in Ewing's sarcoma

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12 December 2020

Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?

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12 December 2020

Five-year survival of patients with Ewing's sarcoma

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12 December 2020

Topotecan and cyclophosphamide in patients with refractory or relapsed Ewing tumors.

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12 December 2020

Treatment of Ewing's sarcoma with adriamycin (NSC-123127)

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12 December 2020

The predictive potential of molecular detection in the nonmetastatic Ewing family of tumors.

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12 December 2020

Classics in oncology. Diffuse endothelioma of bone. James Ewing. Proceedings of the New York Pathological Society, 1921

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12 December 2020

Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence following multi-modality therapy: A report from the Children's Oncology Group

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12 December 2020

High-dose melphalan, etoposide, total-body irradiation, and autologous stem-cell reconstitution as consolidation therapy for high-risk Ewing's sarcoma does not improve prognosis.

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12 December 2020

Biomarkers in cancer staging, prognosis and treatment selection

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12 December 2020

A multidisciplinary study investigating radiotherapy in Ewing's sarcoma: end results of POG #8346. Pediatric Oncology Group

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12 December 2020

Ewing's sarcoma and primitive neuroectodermal tumor in adults: are they different from Ewing's sarcoma and primitive neuroectodermal tumor in children?

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12 December 2020

Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002 [corrected].

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12 December 2020

Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma

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12 December 2020

Ewing sarcoma: prognostic criteria, outcomes and future treatment

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12 December 2020

Preclinical in vivo study of new insulin-like growth factor-I receptor--specific inhibitor in Ewing's sarcoma

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12 December 2020

Ewing sarcoma: its course and treatment in 50 adult patients

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12 December 2020

Cyclophosphamide in children with cancer

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12 December 2020

Ewing sarcoma: radiation dose and target volume

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12 December 2020

Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone

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12 December 2020

Primary metastatic (stage IV) Ewing tumor: survival analysis of 171 patients from the EICESS studies. European Intergroup Cooperative Ewing Sarcoma Studies.

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12 December 2020

Osteogenic and Ewing sarcomas: estimation of necrotic fraction during induction chemotherapy with dynamic contrast-enhanced MR imaging

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12 December 2020

Molecular diagnosis of sarcomas: chromosomal translocations in sarcomas

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12 December 2020

Past failures and future possibilities in Ewing's sarcoma:Experimental and preliminary clinical results

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12 December 2020

Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma.

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12 December 2020

Chemotherapy in the management of osteosarcoma and Ewing's sarcoma

1 reference

12 December 2020

Chemotherapy-induced tumor necrosis as a prognostic factor in localized Ewing's sarcoma of the extremities

1 reference

12 December 2020

Vasculogenesis Plays a Role in the Growth of Ewing's Sarcoma in Vivo

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12 December 2020

Emerging chemotherapeutic strategies and the role of treatment stratification in Ewing sarcoma

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12 December 2020

Ewing sarcoma family of tumors: a model for the new era of integrated laboratory diagnostics

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12 December 2020

The insulin-like growth factor system and sarcomas.

1 reference

12 December 2020

Molecular biology of the Ewing's sarcoma/primitive neuroectodermal tumor family

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12 December 2020

Targeting sarcomas: therapeutic targets and their rational.

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12 December 2020

Preclinical evaluation of vascular-disrupting agents in Ewing's sarcoma family of tumours

1 reference

12 December 2020

Preclinical evaluation of the antineoplastic action of 5-aza-2'-deoxycytidine and different histone deacetylase inhibitors on human Ewing's sarcoma cells

1 reference

12 December 2020

Response to high-dose ifosfamide in patients with advanced/recurrent Ewing sarcoma

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12 December 2020

Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects

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12 December 2020

Ewing's family of tumors in adults: multivariate analysis of survival and long-term results of multimodality therapy in 182 patients

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12 December 2020

EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

1 reference

12 December 2020

Novel bone cancer drugs: investigational agents and control paradigms for primary bone sarcomas (Ewing's sarcoma and osteosarcoma)

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12 December 2020

Adults with Ewing's sarcoma. An analysis of 16 patients at the Dana-Farber Cancer Institute

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12 December 2020

Post-operative radiotherapy for Ewing sarcoma: when, how and how much?

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12 December 2020

The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts

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12 December 2020

Additional antitumor ecteinascidins from a Caribbean tunicate: crystal structures and activities in vivo

1 reference

12 December 2020

Ewing's sarcoma of the bone: ESMO clinical recommendations for diagnosis, treatment and follow-up

1 reference

12 December 2020

Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group

1 reference

12 December 2020

Long-term outcome for patients with non-metastatic Ewing's sarcoma treated with adjuvant and neoadjuvant chemotherapies. 402 patients treated at Rizzoli between 1972 and 1992.

1 reference

12 December 2020

Impact of megatherapy in children with high-risk Ewing's tumours in complete remission: a report from the EBMT Solid Tumour Registry

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12 December 2020

Multidisciplinary treatment of primary Ewing's sarcoma of bone. A 6-year experience of a European Cooperative Trial

1 reference

12 December 2020

Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group

1 reference

12 December 2020

Segregated graft-versus-tumor effect between CNS and non-CNS lesions of Ewing's sarcoma family of tumors

1 reference

12 December 2020

Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target

1 reference

12 December 2020

The neuroectodermal tumor of bone

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12 December 2020

Treatment of metastatic Ewing's sarcoma with actinomycin D (NSC-3053)

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12 December 2020

Therapy for localized Ewing's sarcoma of bone

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12 December 2020

Overview of sarcomas in the adolescent and young adult population

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12 December 2020

Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: Surveillance Epidemiology and End Results data.

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12 December 2020

Irinotecan plus temozolomide for relapsed or refractory neuroblastoma.

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12 December 2020

Vascular endothelial growth factor expression is up-regulated by EWS-ETS oncoproteins and Sp1 and may represent an independent predictor of survival in Ewing's sarcoma

1 reference

12 December 2020

EWS fli-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice

1 reference

12 December 2020

EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro

1 reference

12 December 2020

Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials

1 reference

12 December 2020

EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma

1 reference

12 December 2020

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells

1 reference

12 December 2020

Phase I trial of temozolomide and protracted irinotecan in pediatric patients with refractory solid tumors

1 reference

12 December 2020

Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: a Pediatric Oncology Group phase II study

1 reference

12 December 2020

Treatment of Ewing's sarcoma with concurrent radiotherapy and chemotherapy

1 reference

12 December 2020

High-dose therapy for patients with primary multifocal and early relapsed Ewing's tumors: results of two consecutive regimens assessing the role of total-body irradiation

1 reference

12 December 2020

Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy.

1 reference

12 December 2020

Cyclophosphamide therapy in children with Ewing's sarcoma

1 reference

12 December 2020

Proceedings: Disease-free survival in children with Ewing's sarcoma treated with radiation therapy and adjuvant four-drug sequential chemotherapy

1 reference

12 December 2020

The EWS/FLI1 oncogenic transcription factor deregulates GLI1.

1 reference

12 December 2020

Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future

1 reference

12 December 2020

Treatment of clinically localized Ewing's sarcoma with radiotherapy and combination chemotherapy

1 reference

12 December 2020

Dilemmas associated with congenital ewing sarcoma family tumors

1 reference

12 December 2020

Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults.

1 reference

12 December 2020

Malignant small cell tumor of the thoracopulmonary region in childhood.A distinctive clinicopathologic entity of uncertain histogenesis

1 reference

12 December 2020

Transcriptional signature of Ecteinascidin 743 (Yondelis, Trabectedin) in human sarcoma cells explanted from chemo-naive patients.

1 reference

12 December 2020

10.1007/S11864-009-0104-6

Identifiers

DOI

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20 August 2017

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