Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. (Q37527117)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15456872%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

title

Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex (English)

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3 January 2020

6

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3 January 2020

Frank B Furnari

4

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3 January 2020

Oliver Bogler

7

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3 January 2020

1

Mirko H H Schmidt

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3 January 2020

author name string

Daniela Hoeller

2

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3 January 2020

Jiuhong Yu

3

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3 January 2020

Webster K Cavenee

5

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3 January 2020

language of work or name

English

0 references

publication date

1 October 2004

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Molecular and Cellular Biology

3 January 2020

published in

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volume

24

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3 January 2020

issue

20

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3 January 2020

page(s)

8981-8993

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Role of LBPA and Alix in multivesicular liposome formation and endosome organization

3 January 2020

cites work

1 reference

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Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

23 August 2017

1 reference

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Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases

23 August 2017

1 reference

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SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion

23 August 2017

1 reference

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Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization

23 August 2017

1 reference

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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

23 August 2017

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Negative receptor signalling

23 August 2017

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Grb2 regulates internalization of EGF receptors through clathrin-coated pits

23 August 2017

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Organization of the mouse Ruk locus and expression of isoforms in mouse tissues

23 August 2017

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Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors

23 August 2017

1 reference

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CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases

23 August 2017

1 reference

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Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization

23 August 2017

1 reference

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Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

23 August 2017

1 reference

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Generation of high curvature membranes mediated by direct endophilin bilayer interactions

23 August 2017

1 reference

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SETA: a novel SH3 domain-containing adapter molecule associated with malignancy in astrocytes

23 August 2017

1 reference

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SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=517880

Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=517880

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

23 August 2017

1 reference

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The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=517880

Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=517880

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

23 August 2017

1 reference

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Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid.

23 August 2017

1 reference

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cbl-3: a new mammalian cbl family protein

23 August 2017

1 reference

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Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein

23 August 2017

1 reference

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cbl-b inhibits epidermal growth factor receptor signaling

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=517880

Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction

23 August 2017

1 reference

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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

23 August 2017

1 reference

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Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3

23 August 2017

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

23 August 2017

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Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

23 August 2017

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Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma

23 August 2017

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Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails

23 August 2017

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Structural alterations of the epidermal growth factor receptor gene in human gliomas

23 August 2017

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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

23 August 2017

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Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis

23 August 2017

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Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

14 September 2017

1 reference

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Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=517880

Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=517880

Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor.

28 September 2017

1 reference

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The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

25 June 2018

1 reference

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Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain

25 June 2018

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Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII).

25 June 2018

1 reference

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Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

25 June 2018

1 reference

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Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene.

2 September 2018

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Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor

2 September 2018

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Human malignant glioma therapy using anti-alpha(v)beta3 integrin agents.

2 September 2018

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cbl-b inhibits EGF-receptor-induced apoptosis by enhancing ubiquitination and degradation of activated receptors

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15456872

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.24.20.8981-8993.2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15456872%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

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3 January 2020

PubMed publication ID

15456872

1 reference