Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008. (Q37529806)

20 August 2017

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title

Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008. (English)

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20 August 2017

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Jeffrey W Corbett

1

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PubMed ID

19552511

20 August 2017

language of work or name

English

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publication date

1 July 2009

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Expert Opinion on Therapeutic Patents

20 August 2017

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20 August 2017

19

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20 August 2017

7

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20 August 2017

943-956

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Acetyl-coenzyme A carboxylases: versatile targets for drug discovery

20 August 2017

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Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals

21 January 2018

1 reference

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Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with CP-640186

21 January 2018

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Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice

21 January 2018

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Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal

21 January 2018

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Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.

21 January 2018

1 reference

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Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors

21 January 2018

1 reference

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The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications.

21 January 2018

1 reference

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Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents.

21 January 2018

1 reference

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Inhibitors of mammalian acetyl-CoA carboxylase

21 January 2018

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N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications.

21 January 2018

1 reference

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Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2

21 January 2018

1 reference

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Ligand efficiency: a useful metric for lead selection

21 January 2018

1 reference

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10.1517/13543770902862180

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19552511