Dinucleoside polyphosphates: strong endogenous agonists of the purinergic system. (Q37534917)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19563527%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

review article

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title

Dinucleoside polyphosphates: strong endogenous agonists of the purinergic system (English)

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1 February 2020

2

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1 February 2020

Harald Mischak

3

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1 February 2020

6

Joachim Jankowski

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1 February 2020

author name string

Vera Jankowski

1

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1 February 2020

Michael Morgan

4

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1 February 2020

Walter Zidek

5

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language of work or name

English

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publication date

25 June 2009

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British Journal of Pharmacology

1 February 2020

published in

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1 February 2020

volume

157

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1 February 2020

issue

7

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1 February 2020

page(s)

1142-1153

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Uridine adenosine tetraphosphate acts as an autocrine hormone affecting glomerular filtration rate

1 February 2020

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The thienopyridine derivatives (platelet adenosine diphosphate receptor antagonists), pharmacology and clinical developments

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Vasoactive diadenosine polyphosphates in human placenta: possible candidates in the pathophysiology of pre-eclampsia?

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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Identification and characterization of P(1), P(7)-Di(adenosine-5')-heptaphosphate from human platelets

23 August 2017

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The effects of diadenosine polyphosphates on the cardiovascular system

23 August 2017

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The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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14 September 2017

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Regulation of rat mesangial cell growth by diadenosine phosphates

14 September 2017

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Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.

14 September 2017

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Functional properties of heteromeric P2X(1/5) receptors expressed in HEK cells and excitatory junction potentials in guinea-pig submucosal arterioles

28 September 2017

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Functional and biochemical evidence for heteromeric ATP-gated channels composed of P2X1 and P2X5 subunits.

28 September 2017

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Co-expression of P2X1 and P2X5 receptor subunits reveals a novel ATP-gated ion channel.

28 September 2017

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Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Lack of run-down of smooth muscle P2X receptor currents recorded with the amphotericin permeabilized patch technique, physiological and pharmacological characterization of the properties of mesenteric artery P2X receptor ion channels

28 September 2017

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Diadenosine polyphosphates as antagonists of the endogenous P2Y(1) receptor in rat brain capillary endothelial cells of the B7 and B10 clones

25 June 2018

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Diinosine pentaphosphate (IP5I) is a potent antagonist at recombinant rat P2X1 receptors.

25 June 2018

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Evidence for two different P2X-receptors mediating vasoconstriction of Ap5A and Ap6A in the isolated perfused rat kidney

25 June 2018

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Mediation of the vasoactive properties of diadenosine tetraphosphate via various purinoceptors

25 June 2018

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Purinoceptors mediate renal vasodilation by nitric oxide dependent and independent mechanisms.

25 June 2018

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Coexpression of mRNAs for P2X1, P2X2 and P2X4 receptors in rat vascular smooth muscle: an in situ hybridization and RT-PCR study.

25 June 2018

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P1,P4-diadenosine 5' tetraphosphate induces nitric oxide release from bovine aortic endothelial cells

25 June 2018

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Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate

25 June 2018

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Diadenosine 5',5"-P1,P5-pentaphosphate harbors the properties of a signaling molecule in the heart.

25 June 2018

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Vasoconstrictor and vasodilator effects of guanine nucleotides in the rat aorta.

25 June 2018

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Antagonism of P2X receptors in guinea-pig vas deferens by diinosine pentaphosphate.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Diadenosine polyphosphate hydrolase from presynaptic plasma membranes of Torpedo electric organ

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

The activation of P1- and P2-purinoceptors in the guinea-pig left atrium by diadenosine polyphosphates

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Discrimination by PPADS between endothelial P2Y- and P2U-purinoceptors in the rat isolated mesenteric arterial bed.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Diadenosine polyphosphates regulate cytosolic calcium in human fibroblast cells by interaction with P2x purinoceptors coupled to phospholipase C.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Effects of PPADS and suramin on contractions and cytoplasmic Ca2+ changes evoked by AP4A, ATP and alpha, beta-methylene ATP in guinea-pig urinary bladder

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Abundant amounts of diadenosine 5′,5‴-P1,P4-tetraphosphate are present and releasable, but metabolically inactive, in human platelets

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Variation of Ap4A and other dinucleoside polyphosphates in stressed Drosophila cells.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Vasomotor activity of diadenosine triphosphate and diadenosine tetraphosphate in isolated arteries.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Identification and partial characterization of an adenosine(5')tetraphospho(5')adenosine hydrolase on intact bovine aortic endothelial cells

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Potent effects of AP3A and AP4A on coronary resistance and autacoid release of intact rabbit hearts.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Identification of a unique membrane receptor for adenosine 5',5"'-P1,P4-tetraphosphate.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Dinucleotide polyphosphates contribute to purinergic signalling via inhibition of adenylate kinase activity

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Up4A stimulates endothelium-independent contraction of isolated rat pulmonary artery

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Increased uridine adenosine tetraphosphate concentrations in plasma of juvenile hypertensives.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Carboxyl-terminal splicing enhances physical interactions between the cytoplasmic tails of purinergic P2X receptors

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

1 September 2018

Purinergic signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Adenine nucleotide metabolism in human blood--important roles for leukocytes and erythrocytes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Identification and characterization of splice variants of the human P2X7 ATP channel

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Cloning, up-regulation, and mitogenic role of porcine P2Y2 receptor in coronary artery smooth muscle cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Vascular smooth muscle cells (VSMC) proliferation of streptozotocin-diabetic animals induced by diadenosine polyphosphates

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

The Pattern of Distribution of Selected ATP-Sensitive P2 Receptor Subtypes in Normal Rat Kidney: An Immunohistological Study

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Soluble purine-converting enzymes circulate in human blood and regulate extracellular ATP level via counteracting pyrophosphatase and phosphotransfer reactions

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Ocular safety of INS365 ophthalmic solution, a P2Y2 agonist, in patients with mild to moderate dry eye disease.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Effects of dinucleoside polyphosphates on regulation of coronary vascular tone

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Role of a novel soluble nucleotide phospho-hydrolase from sheep plasma in inhibition of platelet reactivity: hemostasis, thrombosis, and vascular biology

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

P2X receptor immunoreactivity in different arteries from the femoral, pulmonary, cerebral, coronary and renal circulations.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Inhibitory effects of some purinergic agents on ecto-ATPase activity and pattern of stepwise ATP hydrolysis in rat liver plasma membranes.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Molecular cloning and characterization of a novel ATP P2X receptor subtype from embryonic chick skeletal muscle.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Effect of shear stress on the release of soluble ecto-enzymes ATPase and 5'-nucleotidase along with endogenous ATP from vascular endothelial cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Pharmacological characterization of recombinant human and rat P2X receptor subtypes.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Differential regulation of phospholipase A2 (PLA2)-dependent Ca2+ signaling in smooth muscle by cAMP- and cGMP-dependent protein kinases. Inhibitory phosphorylation of PLA2 by cyclic nucleotide-dependent protein kinases

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Coexpression of ligand-gated P2X and G protein-coupled P2Y receptors in smooth muscle. Preferential activation of P2Y receptors coupled to phospholipase C (PLC)-beta1 via Galphaq/11 and to PLC-beta3 via Gbetagammai3.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Dinucleotide receptor modulation by protein kinases (protein kinases A and C) and protein phosphatases in rat brain synaptic terminals.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Coronary effects of diadenosine tetraphosphate resemble those of adenosine in anesthetized pigs: involvement of ATP-sensitive potassium channels.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Pivotal role of phosphate chain length in vasoconstrictor versus vasodilator actions of adenine dinucleotides in rat mesenteric arteries.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Catabolism of Ap3A and Ap4A in human plasma. Purification and characterization of a glycoprotein complex with 5'-nucleotide phosphodiesterase activity

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Presence of diadenosine polyphosphates--Ap4A and Ap5A--in rat brain synaptic terminals. Ca2+ dependent release evoked by 4-aminopyridine and veratridine.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2743832

Tear lipocalin: structure, function and molecular mechanisms of action

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00337.X

Endogenous ATP released by electrical field stimulation causes contraction via P2x- and P2y-purinoceptors in the isolated tail artery of rats

21 January 2018

1 reference

12 December 2020

Ecto-enzymatic hydrolysis of diadenosine polyphosphates by cultured adrenomedullary vascular endothelial cells

1 reference

12 December 2020

In vivo effects of diadenosine polyphosphates on rat renal microcirculation

1 reference

12 December 2020

Induction of proliferation and apoptotic cell death via P2Y and P2X receptors, respectively, in rat glomerular mesangial cells

1 reference

12 December 2020

Characterisation of an ATP receptor mediating mitogenesis in vascular smooth muscle cells

1 reference

12 December 2020

Biochemical evidence for an ecto alkaline phosphodiesterase I in human airways

1 reference

12 December 2020

Extracellular ATP: a growth factor for vascular smooth muscle cells

1 reference

12 December 2020

Diadenosine phosphates and the physiological control of blood pressure

1 reference

12 December 2020

Nucleotide receptor P2u partially mediates ATP-induced cell cycle progression of aortic smooth muscle cells

1 reference

12 December 2020

Characterization of contractile P2 receptors in human coronary arteries by use of the stable pyrimidines uridine 5'-O-thiodiphosphate and uridine 5'-O-3-thiotriphosphate

1 reference

12 December 2020

Vasoactive diadenosine polyphosphates promote growth of cultured renal mesangial cells

1 reference

12 December 2020

Diadenosine 5',5"'-P1,P3-triphosphate in eukaryotic cells: identification and quantitation

1 reference

12 December 2020

Pharmacological and histochemical evidence for P2X receptors in human umbilical vessels

1 reference

12 December 2020

Inhibition of platelet aggregation and the platelet release reaction by α, ω diadenosine polyphosphates

1 reference

12 December 2020

P2X (purinergic) receptor distributions in rat blood vessels

1 reference

12 December 2020

Diadenosine polyphosphates' action on calcium and vessel contraction

1 reference

12 December 2020

The presence of diadenosine 5′,5‴-P 1 ,P 3 -triphosphate (Ap 3 A) in human platelets

1 reference

12 December 2020

The hydrolytic activity of bovine adrenal medullary plasma membranes towards diadenosine polyphosphates is due to alkaline phosphodiesterase-I

1 reference

12 December 2020

P2X receptors counteract the vasodilatory effects of endothelium derived hyperpolarising factor

1 reference

12 December 2020

[Involvement of P2X and P2U receptors in the constrictor effect of ATP on the pancreatic vascular bed]

1 reference

12 December 2020

Multiple P2 receptor subtypes on platelets: a new interpretation of their function

1 reference

12 December 2020

P2X (purinergic) receptor redistribution in rabbit aorta following injury to endothelial cells and cholesterol feeding

1 reference

12 December 2020

Purinergic endothelium-dependent and -independent contractions in rat aorta

1 reference

12 December 2020

Diadenosine polyphosphates directly relax porcine coronary arterial smooth muscle

1 reference

12 December 2020

Identification of a serine protease which activates the mouse heart adenosine 5',5"',P1,P4-tetraphosphate receptor

1 reference

12 December 2020

Carbachol induced release of diadenosine polyphosphates--Ap4A and Ap5A--from perfused bovine adrenal medulla and isolated chromaffin cells

1 reference

12 December 2020

Characterization and quantification of diadenosine hexaphosphate in chromaffin cells: granular storage and secretagogue-induced release

1 reference

12 December 2020

Diadenosine Tetraphosphate Is Co-Released with ATP and Catecholamines from Bovine Adrenal Medulla

1 reference

12 December 2020

Intravascular ADP and soluble nucleotidases contribute to acute prothrombotic state during vigorous exercise in humans

1 reference

12 December 2020

A putative alternatively spliced variant of the P2X(1) purinoreceptor in human bladder

1 reference

12 December 2020

Subcellular distribution studies of diadenosine polyphosphates--Ap4A and Ap5A--in bovine adrenal medulla: presence in chromaffin granules

1 reference

12 December 2020

ATP-stimulated smooth muscle cell proliferation requires independent ERK and PI3K signaling pathways

1 reference

12 December 2020

Ecto-diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A)-hydrolase is expressed as an ectoenzyme in a variety of mammalian and human cells and adds new aspects to the turnover of Ap4A

1 reference

12 December 2020

Direct assessment of renal microvascular responses to P2-purinoceptor agonists

1 reference

12 December 2020

Catabolism of Ap4A and Ap3A in whole blood. The dinucleotides are long-lived signal molecules in the blood ending up as intracellular ATP in the erythrocytes

1 reference

12 December 2020

10.1111/J.1476-5381.2009.00337.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19563527%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19563527%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference