The human alpha defensin HD5 neutralizes JC polyomavirus infection by reducing endoplasmic reticulum traffic and stabilizing the viral capsid. (Q37547573)

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English	The human alpha defensin HD5 neutralizes JC polyomavirus infection by reducing endoplasmic reticulum traffic and stabilizing the viral capsid.	scientific article

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29 February 2020

The human alpha defensin HD5 neutralizes JC polyomavirus infection by reducing endoplasmic reticulum traffic and stabilizing the viral capsid (English)

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29 February 2020

endoplasmic reticulum

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Human polyomavirus 2

object named as

JC polyomavirus

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Christian D Nelson

2

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29 February 2020

4

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29 February 2020

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Stephen R Zins

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29 February 2020

Melissa S Maginnis

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29 February 2020

Bethany A O'Hara

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29 February 2020

Walter J Atwood

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6 November 2013

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29 February 2020

Journal of Virology

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29 February 2020

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29 February 2020

2

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29 February 2020

948-960

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29 February 2020

describes a project that uses

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https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3911681/fullTextXML

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Pro-inflammatory and pro-apoptotic properties of Human Defensin 5.

1 reference

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23 August 2017

Progressive Multifocal Leukoencephalopathy-Associated Mutations in the JC Polyomavirus Capsid Disrupt Lactoseries Tetrasaccharide c Binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Critical determinants of human α-defensin 5 activity against non-enveloped viruses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Functional Determinants of Human Enteric -Defensin HD5: CRUCIAL ROLE FOR HYDROPHOBICITY AT DIMER INTERFACE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

The VP1 subunit of JC polyomavirus recapitulates early events in viral trafficking and is a novel tool to study polyomavirus entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Human alpha defensin 5 expression in the human kidney and urinary tract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

1 reference

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23 August 2017

BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

A large and intact viral particle penetrates the endoplasmic reticulum membrane to reach the cytosol

1 reference

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23 August 2017

Taxonomical developments in the family Polyomaviridae

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23 August 2017

Role of endosomes in simian virus 40 entry and infection

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23 August 2017

The structure of avian polyomavirus reveals variably sized capsids, non-conserved inter-capsomere interactions, and a possible location of the minor capsid protein VP4

1 reference

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23 August 2017

Structure-Function Analysis of the Human JC Polyomavirus Establishes the LSTc Pentasaccharide as a Functional Receptor Motif

1 reference

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23 August 2017

Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Human polyomavirus JC (JCV) infection of human B lymphocytes: a possible mechanism for JCV transmigration across the blood-brain barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Defensins in viral infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Direct evidence from single-cell analysis that human {alpha}-defensins block adenovirus uncoating to neutralize infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Transcriptional regulation of BK virus by nuclear factor of activated T cells

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23 August 2017

Calcium bridge triggers capsid disassembly in the cell entry process of simian virus 40.

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23 August 2017

Progressive multifocal leukoencephalopathy in patients on immunomodulatory therapies

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23 August 2017

Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5

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23 August 2017

Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Seroepidemiology of human polyomaviruses

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23 August 2017

Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

A guided tour into subcellular colocalization analysis in light microscopy

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23 August 2017

SV40 VP2 and VP3 insertion into ER membranes is controlled by the capsid protein VP1: implications for DNA translocation out of the ER.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

JC virus minor capsid proteins Vp2 and Vp3 are essential for virus propagation

1 reference

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23 August 2017

NFAT4 is required for JC virus infection of glial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Invasion of host cells by JC virus identifies a novel role for caveolae in endosomal sorting of noncaveolar ligands

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23 August 2017

Defensins in innate antiviral immunity

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23 August 2017

The role of sialic acid in human polyomavirus infections

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Human alpha-defensins block papillomavirus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Reduced Paneth cell alpha-defensins in ileal Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

ERp29 triggers a conformational change in polyomavirus to stimulate membrane binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease

1 reference

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23 August 2017

Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Progressive multifocal leukoencephalopathy in a patient treated with natalizumab

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3

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23 August 2017

Adenovirus protein VI mediates membrane disruption following capsid disassembly.

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23 August 2017

The human polyomavirus, JCV, uses serotonin receptors to infect cells

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23 August 2017

Human rhinovirus capsid dynamics is controlled by canyon flexibility

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23 August 2017

NP-1, a rabbit alpha-defensin, prevents the entry and intercellular spread of herpes simplex virus type 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Overview of the cellular immunity against JC virus in progressive multifocal leukoencephalopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

JC virus enters human glial cells by clathrin-dependent receptor-mediated endocytosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

23 August 2017

Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy

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23 August 2017

Direct inactivation of viruses by human granulocyte defensins

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23 August 2017

Establishment of a line of human fetal glial cells that supports JC virus multiplication

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23 August 2017

Monocyte-chemotactic activity of defensins from human neutrophils

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23 August 2017

Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain

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23 August 2017

Integrin and defensin modulate the mechanical properties of adenovirus.

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6 September 2017

Host defense peptides and their antimicrobial-immunomodulatory duality

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

6 September 2017

Interaction of the human polyomavirus, JCV, with human B-lymphocytes

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6 September 2017

Mechanism of adenovirus neutralization by Human alpha-defensins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

14 September 2017

JC virus binds to primary human glial cells, tonsillar stromal cells, and B-lymphocytes, but not to T lymphocytes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

28 September 2017

Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

25 June 2018

Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3911681

25 June 2018

Persistence of DNA Sequences of BK Virus and JC Virus in Normal Human Tissues and in Diseased Tissues

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25 June 2018

Extension of JC virus host range to monkey cells by insertion of a simian virus 40 enhancer into the JC virus regulatory region

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25 June 2018

Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection

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1 September 2018

Natalizumab and progressive multifocal leukoencephalopathy: highlights of the International Workshop on JC Virus/PML and Multiple Sclerosis, June 3-4, 2005, Philadelphia PA.

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1 September 2018

Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense

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1 September 2018

Critical role of JC virus-specific CD4 T-cell responses in preventing progressive multifocal leukoencephalopathy

1 reference

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1 September 2018

Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor.

1 reference

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1 September 2018

A novel basis of capsid stabilization by antiviral compounds.

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1 September 2018

Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections

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https://pubmed.ncbi.nlm.nih.gov/24198413

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol

1 reference

https://pubmed.ncbi.nlm.nih.gov/24198413

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Questions and answers about defensins

1 reference

https://pubmed.ncbi.nlm.nih.gov/24198413

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.02766-13

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Europe PubMed Central

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29 February 2020

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Europe PubMed Central

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29 February 2020

PubMed publication ID

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Europe PubMed Central

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29 February 2020

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