Membrane topology of gp41 and amyloid precursor protein: interfering transmembrane interactions as potential targets for HIV and Alzheimer treatment. (Q37556743)

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scientific article published on 18 July 2009

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English	Membrane topology of gp41 and amyloid precursor protein: interfering transmembrane interactions as potential targets for HIV and Alzheimer treatment.	scientific article published on 18 July 2009

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scholarly article

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2 February 2020

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Membrane topology of gp41 and amyloid precursor protein: interfering transmembrane interactions as potential targets for HIV and Alzheimer treatment (English)

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2 February 2020

Alzheimer's disease

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transmembrane protein

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Luis Martinez-Gil

2

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2 February 2020

Ismael Mingarro

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2 February 2020

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2 February 2020

Silvia Tamborero

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18 July 2009

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2 February 2020

Biochimica et Biophysica Acta

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2 February 2020

1788

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2 February 2020

10

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2 February 2020

2132-2141

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Europe PubMed Central

PubMed publication ID

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2 February 2020

Mutations of conserved glycine residues within the membrane-spanning domain of human immunodeficiency virus type 1 gp41 can inhibit membrane fusion and incorporation of Env onto virions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Juxtamembrane protein segments that contribute to recruitment of cholesterol into domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The design of drugs for HIV and HCV

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural Analysis and Assembly of the HIV-1 Gp41 Amino-Terminal Fusion Peptide and the Pretransmembrane Amphipathic-At-Interface Sequence†

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable insertion of Alzheimer Abeta peptide into the ER membrane strongly correlates with its length

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence specificity in the dimerization of transmembrane alpha-helices

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solid-state nuclear magnetic resonance measurements of HIV fusion peptide to lipid distances reveal the intimate contact of beta strand peptide with membranes and the proximity of the Ala-14-Gly-16 region with lipid headgroups

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzhemed: a potential treatment for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hydrophobic internal region of bovine prion protein shares structural and functional properties with HIV type 1 fusion peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta immunisation for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutics for Alzheimer's disease based on the metal hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP processing and the APP-KPI domain involvement in the amyloid cascade.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmembrane structures of amyloid precursor protein dimer predicted by replica-exchange molecular dynamics simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trimeric membrane-anchored gp41 inhibits HIV membrane fusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV entry in macrophages is dependent on intact lipid rafts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biophysical characterization and membrane interaction of the most membranotropic region of the HIV-1 gp41 endodomain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Environment- and sequence-dependent modulation of the double-stranded to single-stranded conformational transition of gramicidin A in membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amino-terminal region of amyloid precursor protein is responsible for neurite outgrowth in rat neocortical explant culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prospects and strategies for the discovery and development of small-molecule inhibitors of six-helix bundle formation in class 1 viral fusion proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of the C-terminus of the glycophorin A transmembrane fragment on the dimerization process

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The in vivo brain interactome of the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solution Conformation and Heparin-induced Dimerization of the Full-length Extracellular Domain of the Human Amyloid Precursor Protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane-transferring sequences of the HIV-1 Gp41 ectodomain assemble into an immunogenic complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and functions of the human amyloid precursor protein: the whole is more than the sum of its parts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrophobic substitutions in the first residue of the CRAC segment of the gp41 protein of HIV.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations within the putative membrane-spanning domain of the simian immunodeficiency virus transmembrane glycoprotein define the minimal requirements for fusion, incorporation, and infectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common prevalence of alanine and glycine in mobile reactive centre loops of serpins and viral fusion peptides: do prions possess a fusion peptide?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein-protein interactions in the membrane: sequence, structural, and biological motifs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipids and membrane microdomains in HIV-1 replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folding and stability of alpha-helical integral membrane proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recruitment of HIV-1 envelope occurs subsequent to lipid mixing: a fluorescence microscopic evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and dynamics of micelle-associated human immunodeficiency virus gp41 fusion domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutinin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a critical motif for the human immunodeficiency virus type 1 (HIV-1) gp41 core structure: implications for designing novel anti-HIV fusion inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exogenous agents that target transmembrane domains of proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and evaluation of sifuvirtide, a novel HIV-1 fusion inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of amyloid precursor protein and amyloid peptide neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the specific amino acid sequence of the membrane-spanning domain of human immunodeficiency virus type 1 in membrane fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of envelope processing and gp41 membrane spanning domain in the formation of human immunodeficiency virus type 1 (HIV-1) fusion-competent envelope glycoprotein complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent HIV fusion inhibitors against Enfuvirtide-resistant HIV-1 strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 envelope glycoprotein-mediated fusion and pathogenesis: implications for therapy and vaccine development

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV fusion peptide and its cross-linked oligomers: efficient syntheses, significance of the trimer in fusion activity, correlation of beta strand conformation with membrane cholesterol, and proximity to lipid headgroups

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural classification of toxic amyloid oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein modulation of lipids, and vice-versa, in membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoinduced reactivity of the HIV-1 envelope glycoprotein with a membrane-embedded probe reveals insertion of portions of the HIV-1 Gp41 cytoplasmic tail into the viral membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cubic phases in phosphatidylcholine-cholesterol mixtures: cholesterol as membrane "fusogen"

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyphenols as potential inhibitors of amyloid aggregation and toxicity: possible significance to Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol in Alzheimer's disease: unresolved questions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: from brain lesions to new drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Copper binding to the Alzheimer's disease amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The functional roles of lipid rafts in T cell activation, immune diseases and HIV infection and prevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinesterase inhibitors and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interfacial pre-transmembrane domains in viral proteins promoting membrane fusion and fission.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane protein structure: prediction versus reality.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The surfactant peptide KL4 sequence is inserted with a transmembrane orientation into the endoplasmic reticulum membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational flexibility and strand arrangements of the membrane-associated HIV fusion peptide trimer probed by solid-state NMR spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical evaluation of the conformational requirements of fusogenic peptides in membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the LWYIK motif located in the human immunodeficiency virus type 1 transmembrane gp41 protein as a distinct determinant for viral infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are fusion peptides a good model to study viral cell fusion?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maturation-dependent human immunodeficiency virus type 1 particle fusion requires a carboxyl-terminal region of the gp41 cytoplasmic tail

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lessons from viruses: controlling the function of transmembrane proteins by interfering transmembrane helices

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The AbetaCs of Abeta-cleaving proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solid-state NMR spectroscopy of human immunodeficiency virus fusion peptides associated with host-cell-like membranes: 2D correlation spectra and distance measurements support a fully extended conformation and models for specific antiparallel strand

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and functional properties of peptides based on the N-terminus of HIV-1 gp41 and the C-terminus of the amyloid-beta protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minimal aggregate size and minimal fusion unit for the first fusion pore of influenza hemagglutinin-mediated membrane fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular structure of amyloid fibrils: insights from solid-state NMR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence dependence of BNIP3 transmembrane domain dimerization implicates side-chain hydrogen bonding and a tandem GxxxG motif in specific helix-helix interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solution studies and structural model of the extracellular domain of the human amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transmembrane domain of influenza hemagglutinin exhibits a stringent length requirement to support the hemifusion to fusion transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of viral entry

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A transmembrane helix dimer: structure and implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A leucine zipper-like sequence from the cytoplasmic tail of the HIV-1 envelope glycoprotein binds and perturbs lipid bilayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular code for transmembrane-helix recognition by the Sec61 translocon

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The membrane proximal external region of the HIV-1 envelope glycoprotein gp41 contributes to the stabilization of the six-helix bundle formed with a matching N' peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of transmembrane helices by the endoplasmic reticulum translocon.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of a conserved proline in the internal fusion peptide of Ebola glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of proline residues in transmembrane helix packing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the membrane-spanning domain of the human immunodeficiency virus envelope glycoprotein that affect fusion activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical shift assignment and structural plasticity of a HIV fusion peptide derivative in dodecylphosphocholine micelles

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of hydrophobic matching on association of model transmembrane fragments containing a minimised glycophorin A dimerisation motif

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Large changes in the CRAC segment of gp41 of HIV do not destroy fusion activity if the segment interacts with cholesterol

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of a novel HIV-1 fusion inhibitor that displays a minimal interface for binding affinity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional role of lipoprotein receptors in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the membrane-spanning domain of human immunodeficiency virus type 1 envelope glycoprotein in cell-cell fusion and virus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV entry inhibitors and their potential in HIV therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structural biology of type I viral membrane fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and plasticity of the human immunodeficiency virus gp41 fusion domain in lipid micelles and bilayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in cell membrane permeability by the lentivirus lytic peptide (LLP-1) of HIV-1 transmembrane protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computational design of peptides that target transmembrane helices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstrating the C-terminal boundary of the HIV 1 fusion conformation in a dynamic ongoing fusion process and implication for fusion inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma-secretase inhibition and modulation for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Affinity of GXXXG Motifs in Transmembrane Helix-Helix Interactions Is Modulated by Long-range Communication

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide inhibitors of beta-amyloid aggregation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of the membrane-perturbing properties of the membrane-proximal external region of human immunodeficiency virus type 1 gp41 to viral fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and characterization of glycophospholipid-anchored human immunodeficiency virus type 1 envelope glycoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic strategies for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of viral membrane fusion and its inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution and three-dimensional structure of AIDS virus envelope spikes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional links between the fusion peptide-proximal polar segment and membrane-proximal region of human immunodeficiency virus gp41 in distinct phases of membrane fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The FE65 proteins and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intramembrane proteolysis by gamma-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide inhibition of HIV-1: current status and future potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteins and cholesterol-rich domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ala-insertion scanning mutagenesis of the glycophorin A transmembrane helix: a rapid way to map helix-helix interactions in integral membrane proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational stability and membrane interaction of the full-length ectodomain of HIV-1 gp41: implication for mode of action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current and future therapy in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity of gamma-secretase and other intramembrane proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein trafficking, processing, and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The HIV fusion peptide adopts intermolecular parallel beta-sheet structure in membranes when stabilized by the adjacent N-terminal heptad repeat: a 13C FTIR study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane interactions of synthetic peptides corresponding to amphipathic helical segments of the human immunodeficiency virus type-1 envelope glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmembrane Domains of Hepatitis C Virus Envelope Glycoproteins: Residues Involved in E1E2 Heterodimerization and Involvement of These Domains in Virus Entry

1 reference

https://pubmed.ncbi.nlm.nih.gov/19619504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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