Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNA (Q37556800)

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scientific article published on 11 December 2013

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English	Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNA	scientific article published on 11 December 2013

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2 March 2020

Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNA (English)

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2 March 2020

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2 March 2020

Patrick J. Hrdlicka

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2 March 2020

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Nicolai K Andersen

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2 March 2020

Brooke A Anderson

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11 December 2013

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2 March 2020

Journal of Organic Chemistry

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2 March 2020

12690-12702

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2 March 2020

Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methyl-ribonucleotides

1 reference

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23 August 2017

Sandwich assay for mixed-sequence recognition of double-stranded DNA: invader-based detection of targets specific to foodborne pathogens

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Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA.

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Allele-selective inhibition of trinucleotide repeat genes

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Silencing disease genes in the laboratory and the clinic

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Synthesis and properties of a bridged nucleic acid with a perhydro-1,2-oxazin-3-one ring

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High-affinity DNA targeting using readily accessible mimics of N2'-functionalized 2'-amino-α-L-LNA.

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Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): tools for fundamental research, diagnostics, and nanotechnology.

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Invader LNA: efficient targeting of short double stranded DNA.

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RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform

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Functionalized 2'-amino-alpha-L-LNA: directed positioning of intercalators for DNA targeting.

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Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA).

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23 August 2017

Harnessing DNA intercalation.

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Pyrene is highly emissive when attached to the RNA duplex but not to the DNA duplex: the structural basis of this difference

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Intercalating nucleic acids containing insertions of 1-O-(1-pyrenylmethyl)glycerol: stabilisation of dsDNA and discrimination of DNA over RNA.

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23 August 2017

DNA analogues: from supramolecular principles to biological properties

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Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures(1).

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MicroRNA: function, detection, and bioanalysis.

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Synthesis and properties of thymidines with six-membered amide bridge.

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Designing chemically modified oligonucleotides for targeted gene silencing

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6 September 2017

Intramolecular free-radical cyclization reactions on pentose sugars for the synthesis of carba-LNA and carba-ENA and the application of their modified oligonucleotides as potential RNA targeted therapeutics.

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An overview of sugar-modified oligonucleotides for antisense therapeutics

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Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

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Effect of LNA modifications on small molecule binding to nucleic acids

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6 September 2017

alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): synthesis and properties

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6 September 2017

2'-Pyrene modified oligonucleotide provides a highly sensitive fluorescent probe of RNA.

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Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd).

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Physico-chemical probes of intercalation

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Synthesis and pairing properties of oligodeoxynucleotides containing bicyclo-RNA and bicyclo-ANA modifications.

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Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease activity, thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry.

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1 September 2018

N2'-functionalized 2'-amino-alpha-L-LNA adenine derivatives--efficient targeting of single stranded DNA.

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Pyrene-labeled base-discriminating fluorescent DNA probes for homogeneous SNP typing

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1 reference

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A constrained tricyclic nucleic acid analogue of α-L-LNA: investigating the effects of dual conformational restriction on duplex thermal stability

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Quencher-free, end-stacking oligonucleotides for probing single-base mismatches in DNA

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1 reference

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C5-functionalized DNA, LNA, and α-L-LNA: positional control of polarity-sensitive fluorophores leads to improved SNP-typing

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2′-N-(Pyren-1-yl)acetyl-2′-Amino-α-L-LNA: Synthesis and Detection of Single Nucleotide Mismatches in DNA and RNA Targets

1 reference

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Identifiers

10.1021/JO4022937

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2 March 2020

PMC publication ID

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2 March 2020

PubMed publication ID

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24304240%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

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