P2Y(12) inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use. (Q37562606)

21 August 2017

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title

P2Y(12) inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use. (English)

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21 August 2017

1

Lars Wallentin

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21 August 2017

publication date

24 July 2009

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21 August 2017

published in

European Heart Journal

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21 August 2017

volume

30

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21 August 2017

issue

16

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21 August 2017

page(s)

1964-1977

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Platelet activation and atherothrombosis

21 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo

21 January 2018

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21 January 2018

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21 January 2018

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Loading with 600 mg clopidogrel in patients with coronary artery disease with and without chronic clopidogrel therapy

21 January 2018

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21 January 2018

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21 January 2018

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Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment

21 January 2018

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Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation

21 January 2018

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Dose-dependent inhibition of human platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects

21 January 2018

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Greater inhibition of platelet aggregation and reduced response variability with prasugrel versus clopidogrel: an integrated analysis.

21 January 2018

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Pharmacodynamics of ticlopidine in man in relation to plasma and blood cell concentration

21 January 2018

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Initial experience with an intravenous P2Y12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial

21 January 2018

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The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function

21 January 2018

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21 January 2018

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Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel

21 January 2018

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Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome.

21 January 2018

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Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients.

21 January 2018

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Effect of CYP3A5*3 genotype on the pharmacokinetics and antiplatelet effect of clopidogrel in healthy subjects

21 January 2018

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The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: a possible mechanism for clopidogrel resistance

21 January 2018

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21 January 2018

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Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study

21 January 2018

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The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects

21 January 2018

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Genetic polymorphism of CYP2D6 and CYP2C19 in east- and southern African populations including psychiatric patients

21 January 2018

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Proton pump inhibitors--differences emerge in hepatic metabolism

21 January 2018

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Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study

21 January 2018

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21 January 2018

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Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel

21 January 2018

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A population-based study of the drug interaction between proton pump inhibitors and clopidogrel

21 January 2018

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Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects.

21 January 2018

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P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study.

21 January 2018

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Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease

21 January 2018

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Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome

21 January 2018

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Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel

21 January 2018

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Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHP296

Prasugrel versus clopidogrel in patients with acute coronary syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHP296

21 January 2018

Identifiers

DOI

10.1093/EURHEARTJ/EHP296

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21 August 2017

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