Molecular targets for antiviral therapy of cytomegalovirus infections (Q37573779)

21 August 2017

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title

Molecular targets for antiviral therapy of cytomegalovirus infections (English)

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21 August 2017

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2

Thomas Stamminger

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21 August 2017

Manfred Marschall

1

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21 August 2017

1 August 2009

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21 August 2017

12

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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21 August 2017

4

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21 August 2017

6

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21 August 2017

731-742

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CMV as a cofactor enhancing progression of AIDS.

21 August 2017

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Recent advances in the prevention and treatment of congenital cytomegalovirus infections

21 January 2018

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Emergence of late cytomegalovirus central nervous system disease in hematopoietic stem cell transplant recipients

21 January 2018

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Combinations of Cyclophilin Inhibitor NIM811 with Hepatitis C Virus NS3-4A Protease or NS5B Polymerase Inhibitors Enhance Antiviral Activity and Suppress the Emergence of Resistance

21 January 2018

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Human cytomegalovirus: host immune modulation by the viral US3 gene

21 January 2018

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Essential role for either TRS1 or IRS1 in human cytomegalovirus replication

21 January 2018

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Insights into the mechanisms of CMV-mediated interference with cellular apoptosis

21 January 2018

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Human cytomegalovirus immediate-early 2 gene expression blocks virus-induced beta interferon production

21 January 2018

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New insights into the role of the subnuclear structure ND10 for viral infection

21 January 2018

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A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling

21 January 2018

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Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes

21 January 2018

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Synergistic induction of intercellular adhesion molecule-1 by the human cytomegalovirus transactivators IE2p86 and pp71 is mediated via an Sp1-binding site

21 January 2018

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Inhibition of cytomegalovirus immediate early gene expression: a therapeutic option?

21 January 2018

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Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection

21 January 2018

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Human cytomegalovirus proteins encoded by UL37 exon 1 protect infected fibroblasts against virus-induced apoptosis and are required for efficient virus replication

21 January 2018

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21 January 2018

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The antiviral activities of artemisinin and artesunate.

21 January 2018

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New cell-based indicator assays for the detection of human cytomegalovirus infection and screening of inhibitors of viral immediate-early 2 protein activity.

21 January 2018

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Distinct and separate roles for herpesvirus-conserved UL97 kinase in cytomegalovirus DNA synthesis and encapsidation

21 January 2018

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The UL97 protein kinase of human cytomegalovirus and homologues in other herpesviruses: impact on virus and host.

21 January 2018

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Cellular p32 recruits cytomegalovirus kinase pUL97 to redistribute the nuclear lamina

21 January 2018

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Cytomegaloviral proteins that associate with the nuclear lamina: components of a postulated nuclear egress complex

21 January 2018

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Cytomegaloviral protein kinase pUL97 interacts with the nuclear mRNA export factor pUL69 to modulate its intranuclear localization and activity

21 January 2018

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The protein kinase pUL97 of human cytomegalovirus interacts with and phosphorylates the DNA polymerase processivity factor pUL44.

21 January 2018

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Mapping of a self-interaction domain of the cytomegalovirus protein kinase pUL97.

21 January 2018

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Analysis of the structure-activity relationship of four herpesviral UL97 subfamily protein kinases reveals partial but not full functional conservation

21 January 2018

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Inhibitors of human cytomegalovirus replication drastically reduce the activity of the viral protein kinase pUL97.

21 January 2018

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Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function.

21 January 2018

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Protein kinase inhibitors of the quinazoline class exert anti-cytomegaloviral activity in vitro and in vivo

21 January 2018

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Novel chemical class of pUL97 protein kinase-specific inhibitors with strong anticytomegaloviral activity

21 January 2018

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Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action

21 January 2018

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Direct targeting of human cytomegalovirus protein kinase pUL97 by kinase inhibitors is a novel principle for antiviral therapy

21 January 2018

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Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase

21 January 2018

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FDA drug approval summary: gefitinib (ZD1839) (Iressa) tablets

21 January 2018

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Maribavir: a novel antiviral agent with activity against cytomegalovirus

21 January 2018

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Resistance of human cytomegalovirus to the benzimidazole L-ribonucleoside maribavir maps to UL27

21 January 2018

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Human cytomegalovirus DNA replication: antiviral targets and drugs

21 January 2018

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Identification of acetylated, tetrahalogenated benzimidazole D-ribonucleosides with enhanced activity against human cytomegalovirus.

21 January 2018

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Functional profiling of a human cytomegalovirus genome

21 January 2018

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Broad-spectrum antiherpes activities of 4-hydroxyquinoline carboxamides, a novel class of herpesvirus polymerase inhibitors

21 January 2018

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Antiviral strategies to combat cytomegalovirus infections in transplant recipients

21 January 2018

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Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase

21 January 2018

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Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.

21 January 2018

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Regulation of cyclin-Cdk activity in mammalian cells

21 January 2018

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Pharmacological inhibitors of cyclin-dependent kinases

21 January 2018

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Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH

21 January 2018

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P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

21 January 2018

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Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome

21 January 2018

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Cyclin-dependent kinase activity is required for efficient expression and posttranslational modification of human cytomegalovirus proteins and for production of extracellular particles

21 January 2018

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Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.

21 January 2018

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Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production

21 January 2018

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The S phase of the cell cycle and its perturbation by human cytomegalovirus

21 January 2018

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Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus

21 January 2018

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Five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs

21 January 2018

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Cyclin-dependent Kinases Phosphorylate the Cytomegalovirus RNA Export Protein pUL69 and Modulate Its Nuclear Localization and Activity

21 January 2018

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Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication

21 January 2018

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CDK9 a potential target for drug development.

21 January 2018

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ATP-noncompetitive inhibitors of CDK-cyclin complexes.

21 January 2018

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Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells

21 January 2018

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Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection

21 January 2018

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Antagonism of platelet-derived growth factor receptor in non small cell lung cancer: rationale and investigations

21 January 2018

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Sorafenib: a review of its use in advanced hepatocellular carcinoma

21 January 2018

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From single- to multi-target drugs in cancer therapy: when aspecificity becomes an advantage.

21 January 2018

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Proteasome inhibitor MG132 blocks viral DNA replication and assembly of human cytomegalovirus.

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FMB.09.40

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21 August 2017

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PubMed ID

19659428