Targeting the IGF1 axis in cancer proliferation (Q37575541)

21 August 2017

1 reference

title

Targeting the IGF1 axis in cancer proliferation (English)

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21 August 2017

1

Ilan Bruchim

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21 August 2017

Zohar Attias

2

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PubMed ID

19663648

21 August 2017

Haim Werner

series ordinal

3

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PubMed ID

19663648

21 August 2017

language of work or name

English

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publication date

1 October 2009

1 reference

Expert Opinion on Therapeutic Targets

21 August 2017

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21 August 2017

13

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21 August 2017

10

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21 August 2017

1179-1192

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The somatomedin hypothesis 2007: 50 years later

21 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The somatotropic axis and aging: mechanisms and persistent questions about practical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

IGF signaling defects as causes of growth failure and IUGR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The role of the IGF system in cancer growth and metastasis: overview and recent insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Insulin and insulin-like growth factor signalling in neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The insulin-like growth factor-I receptor as a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The new kid on the block(ade) of the IGF-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Overview of the IGF-I system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The IGF‐1 receptor in cancer biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The insulin-like growth factor-I receptor as an oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Is the mannose-6-phosphate/insulin-like growth factor 2 receptor coded by a breast cancer suppressor gene?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Cellular actions of the insulin-like growth factor binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The role of insulin-like growth factor binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Potential of proteomics towards the investigation of the IGF-independent actions of IGFBP-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Spatial determinants of specificity in insulin action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Growth hormone, IGF-I and cancer. Less intervention to avoid cancer? More intervention to prevent cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The constitutively active mutant Galpha13 transforms mouse fibroblast cells deficient in insulin-like growth factor-I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The IGFI receptor gene: a molecular target for disrupted transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The contradictions of the insulin-like growth factor 1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Elevated insulin receptor content in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Reexpression of the type 1 insulin-like growth factor receptor inhibits the malignant phenotype of simian virus 40 T antigen immortalized human prostate epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

BRCA1–Sp1 interactions in transcriptional regulation of the IGF‐IR gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Mutations of the VHL tumour suppressor gene in renal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

IGF-I and breast cancer: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Insulin-like growth factor (IGF)-I and IGF-binding protein 3 and the risk of premenopausal breast cancer: a meta-analysis of literature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Circulating Insulin-Like Growth Factor-I and Binding Protein-3 and the Risk of Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years on.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

IGF system components as prognostic markers in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Expression of insulin-like growth factor 1 receptor in primary breast cancer: immunohistochemical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

IGF and insulin receptor signaling in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

IGF-1 receptor inhibitors in clinical trials--early lessons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death--proliferative and anti-apoptotic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Insulin-like growth factor II mediates epidermal growth factor-induced mitogenesis in cervical cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Insulin-like growth factor axis and oncogenic human papillomavirus natural history

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The insulin-like growth factor insulin system in epithelial ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

IGF axis gene expression patterns are prognostic of survival in epithelial ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Insulin-like growth factor receptor I targeting in epithelial ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Endometrial cancer and the IGF system: a case-control study in Greece.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Insulin-like growth factor 2 and its receptors (IGF 1R and IGF 2R/mannose 6-phosphate) in endometrial adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Insulin-Like Growth Factor (IGF) family and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

The insulin-like growth factor 1 receptor in cancer: old focus, new future

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulinlike growth factor type 1 Receptor monoclonal antibody CP-751,871 in patients with multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

AMG 479, a fully human anti-insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Chemosensitization of human prostate cancer using antisense agents targeting the type 1 insulin-like growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903201702

10.1517/14728220903201702

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19663648