Progress and Prospects: genetic treatments for disorders of bones and joints (Q37579041)

21 August 2017

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title

Progress and Prospects: genetic treatments for disorders of bones and joints (English)

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21 August 2017

C H Evans

1

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PubMed ID

19675584

21 August 2017

S C Ghivizzani

series ordinal

2

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PubMed ID

19675584

21 August 2017

P D Robbins

series ordinal

3

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21 August 2017

1 August 2009

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21 August 2017

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21 August 2017

16

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21 August 2017

944-952

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21 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/gt.2009.73

21 August 2017

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cites work

Orthopedic gene therapy in 2008.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Gene therapy of the rheumatic diseases: 1998 to 2008.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Long-term suppression of experimental arthritis following intramuscular administration of a pseudotyped AAV2/1-TNFR:Fc Vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Local delivery of beta interferon using an adeno-associated virus type 5 effectively inhibits adjuvant arthritis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Reduction of arthritis following intra-articular administration of an adeno-associated virus serotype 5 expressing a disease-inducible TNF-blocking agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Inflammation-inducible anti-TNF gene expression mediated by intra-articular injection of serotype 5 adeno-associated virus reduces arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Synoviocyte infection with adeno-associated virus (AAV) is neutralized by human synovial fluid from arthritis patients and depends on AAV serotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Perspectives on the use of gene therapy for chronic joint diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Application of inflammation-responsive promoter for an in vitro arthritis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Application of a disease-regulated promoter is a safer mode of local IL-4 gene therapy for arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Intra-articular electrotransfer of plasmid encoding soluble TNF receptor variants in normal and arthritic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

In vivo inhibition of angiogenesis by interleukin-13 gene therapy in a rat model of rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Co-expression of IL-18 binding protein and IL-4 regulates Th1/Th2 cytokine response in murine collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

IGF-1 gene therapy to protect articular cartilage in a rat model of joint damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Efficient suppression of murine arthritis by combined anticytokine small interfering RNA lipoplexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Cartilage proteoglycan-specific T cells as vectors of immunomodulatory biologicals in chronic proteoglycan-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Arthritis gene therapy's first death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Gene therapy and cement injection for restabilization of loosened hip prostheses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Facilitated endogenous repair: making tissue engineering simple, practical, and economical

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Osteogenic gene regulation and relative acceleration of healing by adenoviral-mediated transfer of human BMP-2 or -6 in equine osteotomy and ostectomy models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

The osteoinductive properties of Nell-1 in a rat spinal fusion model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Osterix overexpression in mesenchymal stem cells stimulates healing of critical-sized defects in murine calvarial bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Stem cells from human fat as cellular delivery vehicles in an athymic rat posterolateral spine fusion model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Novel gene-modified-tissue engineering of cartilage using stable transforming growth factor-beta1-transfected mesenchymal stem cells grown on chitosan scaffolds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Adeno-associated viral gene transfer of transforming growth factor-beta1 to human mesenchymal stem cells improves cartilage repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Cell-based resurfacing of large cartilage defects: long-term evaluation of grafts from autologous transgene-activated periosteal cells in a porcine model of osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Comparative effects of bone morphogenetic proteins and Sox9 overexpression on matrix accumulation by bovine anulus fibrosus cells: implications for anular repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Cell therapy using articular chondrocytes overexpressing BMP-7 or BMP-10 in a rabbit disc organ culture model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Biologic response of human intervertebral disc cells to gene therapy cocktail.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

BMP-14 gene therapy increases tendon tensile strength in a rat model of Achilles tendon injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

ACL reconstruction in a rabbit model using irradiated Achilles allograft seeded with mesenchymal stem cells or PDGF-B gene-transfected mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

7 January 2021

Prothymosin alpha lacking the nuclear localization signal as an effective gene therapeutic strategy in collagen-induced arthritis

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

7 January 2021

Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

7 January 2021

Local delivery of a recombinant adenoassociated vector containing a tumour necrosis factor alpha antagonist gene in inflammatory arthritis: a phase 1 dose-escalation safety and tolerability study.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

7 January 2021

Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector dose

1 reference

https://api.crossref.org/works/10.1038%2FGT.2009.73

7 January 2021

Identifiers

DOI

10.1038/GT.2009.73

1 reference

21 August 2017

1 reference

PubMed ID

19675584