Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane. (Q37583534)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24375408%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24375408%20AND%20SRC:MED&resulttype=core&format=json

intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity

3 March 2020

main subject

Drosophila

0 references

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0097682

Transient receptor potential cation channel, subfamily M Dmel_CG44240

1 reference

Transient receptor potential cation channel, mucolipin Dmel_CG8743

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

YU HUANG

2

1 reference

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3 March 2020

author name string

Xinghua Feng

1

1 reference

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3 March 2020

Yungang Lu

3

1 reference

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3 March 2020

Jian Xiong

4

1 reference

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3 March 2020

Ching-On Wong

5

1 reference

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3 March 2020

Pu Yang

6

1 reference

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3 March 2020

Jintang Xia

7

1 reference

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3 March 2020

De Chen

8

1 reference

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3 March 2020

Guangwei Du

9

1 reference

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3 March 2020

Kartik Venkatachalam

10

1 reference

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3 March 2020

Xuefeng Xia

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24375408%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Michael X Zhu

12

1 reference

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3 March 2020

language of work or name

English

0 references

publication date

27 December 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24375408%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

3 March 2020

published in

1 reference

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3 March 2020

volume

289

1 reference

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3 March 2020

issue

7

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3 March 2020

page(s)

4262-4272

1 reference

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mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state

3 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Drosophila TRPML is required for TORC1 activation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Phosphoinositide isoforms determine compartment-specific ion channel activity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Mucolipins: Intracellular TRPML1-3 channels

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Constitutive activity of the human TRPML2 channel induces cell degeneration

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Neuropathology of the Mcoln1(-/-) knockout mouse model of mucolipidosis type IV.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Direct regulation of BK channels by phosphatidylinositol 4,5-bisphosphate as a novel signaling pathway

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Neurologic, gastric, and opthalmologic pathologies in a murine model of mucolipidosis type IV

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Mucolipin 1: endocytosis and cation channel--a review

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

The neurogenetics of mucolipidosis type IV

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Abnormal transport along the lysosomal pathway in mucolipidosis, type IV disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Acidification of the endocytic and exocytic pathways

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Feast or famine: role of TRPML in preventing cellular amino acid starvation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

CUP-5, the C. elegans ortholog of the mammalian lysosomal channel protein MLN1/TRPML1, is required for proteolytic degradation in autolysosomes

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Identification of the gene causing mucolipidosis type IV.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924289

Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24375408

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.506501

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24375408%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24375408%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

PubMed publication ID

24375408

1 reference