Agonist efficacy and receptor desensitization: from partial truths to a fuller picture. (Q37589707)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19719779%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

review article

1 reference

title

Agonist efficacy and receptor desensitization: from partial truths to a fuller picture (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19719779%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19719779%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

author name string

Steven J Charlton

series ordinal

1

1 reference

21 August 2017

language of work or name

English

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publication date

1 September 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19719779%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Pharmacology

6 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19719779%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

158

1 reference

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6 February 2020

issue

1

1 reference

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6 February 2020

page(s)

165-168

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19719779%20AND%20SRC:MED&resulttype=core&format=json

The long-acting beta-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells

6 February 2020

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Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation

23 August 2017

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23 August 2017

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Desensitisation of mast cell beta2-adrenoceptor-mediated responses by salmeterol and formoterol.

23 August 2017

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23 August 2017

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Partial agonists and G protein-coupled receptor desensitization

23 August 2017

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Influence of receptor number on the stimulation by salmeterol of gene transcription in CHO-K1 cells transfected with the human beta2-adrenoceptor

23 August 2017

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Salmeterol tachyphylaxis in steroid treated asthmatic subjects

23 August 2017

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Subsensitivity of bronchodilator and systemic beta 2 adrenoceptor responses after regular twice daily treatment with eformoterol dry powder in asthmatic patients

23 August 2017

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Salmeterol-induced desensitization, internalization and phosphorylation of the human beta2-adrenoceptor

23 August 2017

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Agonist-specific patterns of beta 2-adrenoceptor responses in human airway cells during prolonged exposure

6 September 2017

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beta2-adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists

14 September 2017

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Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization

28 September 2017

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Airway subsensitivity with long-acting beta 2-agonists. Is there cause for concern?

25 June 2018

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Inhaled formoterol dry powder in the treatment of patients with reversible obstructive airway disease. A 3-month, placebo-controlled comparison of the efficacy and safety of formoterol and salbutamol, followed by a 12-month trial with formoterol

25 June 2018

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Operational models of pharmacological agonism.

25 June 2018

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Differential receptor occupancy requirements for muscarinic cholinergic stimulation of inositol lipid hydrolysis in brain and in neuroblastomas.

25 June 2018

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Combining inhaled glucocorticoids and long acting beta(2)-adrenoceptor agonists in asthma and COPD.

25 June 2018

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In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (indacaterol), a novel inhaled beta(2) adrenoceptor agonist with a 24-h duration of action

1 September 2018

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Rapid onset of tolerance to beta-agonist bronchodilation

1 September 2018

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The bronchodilator response to salmeterol is maintained with regular, long-term use in patients with COPD.

1 September 2018

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Tolerance to bronchodilating effects of salmeterol in COPD

1 September 2018

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A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol

1 September 2018

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Tolerance to the protective effect of salmeterol on allergen challenge can be partially restored by the withdrawal of salmeterol regular treatment

1 September 2018

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Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma

1 September 2018

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12 December 2020

Evidence of tachyphylaxis associated with salmeterol treatment of chronic obstructive pulmonary disease patients

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12 December 2020

Inhaled salmeterol and salbutamol in asthmatic patients. An evaluation of asthma symptoms and the possible development of tachyphylaxis

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12 December 2020

Rapid Onset of Tolerance to the Bronchoprotective Effect of Salmeterol

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12 December 2020

Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor

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12 December 2020

Tolerance to the bronchoprotective effect of salmeterol 12 hours after starting twice daily treatment

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12 December 2020

Effects of treatment with formoterol on bronchoprotection against methacholine

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12 December 2020

Subsensitivity to bronchoprotection against adenosine monophosphate challenge following regular once-daily formoterol

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12 December 2020

The beta-adrenoceptor

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12 December 2020

Sustained bronchoprotection, bronchodilatation, and symptom control during regular formoterol use in asthma of moderate or greater severity. The Canadian FO/OD1 Study Group

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12 December 2020

Beta-adrenoceptor reserve in human lung: a comparison between airway smooth muscle and mast cells

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12 December 2020

Receptor-reserve and threshold-phenomena. II. Theories on drug-action and a quantitative approach to spare receptors and threshold values

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12 December 2020

10.1111/J.1476-5381.2009.00352.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19719779%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19719779%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

19719779

1 reference