Blood-brain barrier transporters and response to CNS-active drugs (Q37591290)

21 August 2017

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title

Blood-brain barrier transporters and response to CNS-active drugs (English)

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21 August 2017

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Bradley L Urquhart

1

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PubMed ID

19727692

21 August 2017

Richard B Kim

series ordinal

2

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21 August 2017

1 November 2009

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European Journal of Clinical Pharmacology

21 August 2017

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21 August 2017

65

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21 August 2017

11

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21 August 2017

1063-1070

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https://scigraph.springernature.com/pub.10.1007/s00228-009-0714-8

21 August 2017

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cites work

Characterisation of cerivastatin as a P-glycoprotein substrate: studies in P-glycoprotein-expressing cell monolayers and mdr1a/b knock-out mice

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00228-009-0714-8

Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants

21 January 2018

1 reference

12 December 2020

Multispecific amphipathic substrate transport by an organic anion transporter of human liver.

1 reference

12 December 2020

P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin

1 reference

12 December 2020

A Phase II trial of paclitaxel and topotecan with filgrastim in patients with recurrent or refractory glioblastoma multiforme or anaplastic astrocytoma

1 reference

12 December 2020

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

12 December 2020

P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan

1 reference

12 December 2020

In vivo evaluation of P-glycoprotein and breast cancer resistance protein modulation in the brain using [(11)C]gefitinib

1 reference

12 December 2020

P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion

1 reference

12 December 2020

Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens

1 reference

12 December 2020

Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia

1 reference

12 December 2020

Breast cancer resistance protein interacts with various compounds in vitro, but plays a minor role in substrate efflux at the blood-brain barrier

1 reference

12 December 2020

P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution

1 reference

12 December 2020

P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists

1 reference

12 December 2020

Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion

1 reference

12 December 2020

Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein

1 reference

12 December 2020

Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic a

1 reference

12 December 2020

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry

1 reference

12 December 2020

Central and peripheral nervous system toxicity of common chemotherapeutic agents.

1 reference

12 December 2020

Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class.

1 reference

12 December 2020

Plasma membrane localization of multidrug resistance-associated protein homologs in brain capillary endothelial cells

1 reference

12 December 2020

Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08.

1 reference

12 December 2020

Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier

1 reference

12 December 2020

Identification of influx transporter for the quinolone antibacterial agent levofloxacin

1 reference

12 December 2020

Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice.

1 reference

12 December 2020

Localisation of breast cancer resistance protein in microvessel endothelium of human brain

1 reference

12 December 2020

P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine.

1 reference

12 December 2020

Intestinal drug transporter expression and the impact of grapefruit juice in humans

1 reference

12 December 2020

A multidrug resistance transporter from human MCF-7 breast cancer cells

1 reference

12 December 2020

Studies on the anti-tumor activities of the soy isoflavone daidzein on murine neuroblastoma cells

1 reference

12 December 2020

Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies

1 reference

12 December 2020

Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity

1 reference

12 December 2020

The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib

1 reference

12 December 2020

Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs

1 reference

12 December 2020

Active efflux of the 5-HT(1A) receptor agonist flesinoxan via P-glycoprotein at the blood-brain barrier

1 reference

12 December 2020

Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin

1 reference

12 December 2020

Mass spectrometric determination of Genistein tissue distribution in diet-exposed Sprague-Dawley rats

1 reference

12 December 2020

Topotecan treatment of adults with primary malignant glioma. The Brain Tumor Center at Duke.

1 reference

12 December 2020

Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein

1 reference

12 December 2020

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

1 reference

12 December 2020

Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats.

1 reference

12 December 2020

Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice

1 reference

12 December 2020

Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.

1 reference

12 December 2020

Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein

1 reference

12 December 2020

Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain

1 reference

12 December 2020

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

12 December 2020

Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells

1 reference

12 December 2020

Response to topotecan of symptomatic brain metastases of small-cell lung cancer also after whole-brain irradiation. a multicentre phase II study

1 reference

12 December 2020

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

12 December 2020

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine

1 reference

12 December 2020

Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra.

1 reference

12 December 2020

In vitro and in vivo investigations on fluoroquinolones; effects of the P-glycoprotein efflux transporter on brain distribution of sparfloxacin.

1 reference

12 December 2020

GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier

1 reference

12 December 2020

Neuroexcitatory actions of Tamiflu and its carboxylate metabolite

1 reference

12 December 2020

The role of topotecan in the treatment of brain metastases

1 reference

12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

12 December 2020

Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain

1 reference

12 December 2020

Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier

1 reference

12 December 2020

Mrp4 confers resistance to topotecan and protects the brain from chemotherapy

1 reference

12 December 2020

An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers

1 reference

12 December 2020

10.1007/S00228-009-0714-8

Identifiers

DOI

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21 August 2017

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PubMed ID

19727692