Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment (Q37593696)

21 August 2017

Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment (English)

1 reference

21 August 2017

1 reference

4

1 reference

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7 June 2020

Stephen J. Hill

10

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7 June 2020

Fiona H. Marshall

12

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7 June 2020

Christopher J Langmead

9

object named as

Christopher J Langmead

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7 June 2020

author name string

Catherine J Hutchings

1

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7 June 2020

Gabriella Cseke

2

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7 June 2020

Greg Osborne

3

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7 June 2020

Andrei Zhukov

5

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7 June 2020

Markus Koglin

6

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7 June 2020

Ali Jazayeri

7

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7 June 2020

Jahnavi Pandya-Pathak

8

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7 June 2020

Malcolm Weir

11

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7 June 2020

language of work or name

1 reference

1 January 2014

1 reference

21 August 2017

Monoclonal Antibodies

1 reference

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7 June 2020

volume

6

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7 June 2020

issue

1

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7 June 2020

page(s)

246-261

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Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor

7 June 2020

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23 August 2017

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Opportunities for functional selectivity in GPCR antibodies

23 August 2017

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Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7.

23 August 2017

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Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

23 August 2017

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23 August 2017

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Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation

23 August 2017

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23 August 2017

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23 August 2017

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Nanodisc-incorporated hemagglutinin provides protective immunity against influenza virus infection

23 August 2017

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Production of antibodies against multipass membrane proteins expressed in human tumor cells using dendritic cell immunization

23 August 2017

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Constitutive dimerization of the G-protein coupled receptor, neurotensin receptor 1, reconstituted into phospholipid bilayers

23 August 2017

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Structure of a beta1-adrenergic G-protein-coupled receptor

23 August 2017

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Virus-like display of a neo-self antigen reverses B cell anergy in a B cell receptor transgenic mouse model

23 August 2017

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Conformational thermostabilization of the beta1-adrenergic receptor in a detergent-resistant form

23 August 2017

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

23 August 2017

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beta(1)-Adrenergic receptor function, autoimmunity, and pathogenesis of dilated cardiomyopathy.

23 August 2017

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Allosteric modulation of the cannabinoid CB1 receptor

23 August 2017

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Anti-CXCR4 monoclonal antibodies recognizing overlapping epitopes differ significantly in their ability to inhibit entry of human immunodeficiency virus type 1.

23 August 2017

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G-protein coupled receptors as allosteric machines

23 August 2017

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Analysis of G-protein-coupled receptor dimerization following chemokine signaling

23 August 2017

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Antigenically distinct conformations of CXCR4.

23 August 2017

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The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway

23 August 2017

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The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2

23 August 2017

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

23 August 2017

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Mapping of a functional autoimmune epitope on the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy

23 August 2017

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23 August 2017

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Measurements of β-arrestin recruitment to activated seven transmembrane receptors using enzyme complementation

6 September 2017

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Characterization of G-protein coupled receptor modulators using homogeneous cAMP assays

6 September 2017

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β1 -adrenergic receptor autoantibodies from heart failure patients enhanced TNF-α secretion in RAW264.7 macrophages in a largely PKA-dependent fashion

6 September 2017

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6 September 2017

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Drug-like actions of autoantibodies against receptors of the autonomous nervous system and their impact on human heart function

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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14 September 2017

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Anti-beta1-adrenergic receptor autoantibodies are potent stimulators of the ERK1/2 pathway in cardiac cells

14 September 2017

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Essential role for the second extracellular loop in C5a receptor activation

14 September 2017

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Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.

14 September 2017

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Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods.

25 June 2018

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Pro-apoptotic effect of anti-β1-adrenergic receptor antibodies in periodontitis patients.

25 June 2018

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Ventricular arrhythmias are related to the presence of autoantibodies with adrenergic activity in chronic chagasic patients with preserved left ventricular function.

1 September 2018

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Marketed therapeutic antibodies compendium

1 September 2018

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Enhancement of antibody responses to native G protein-coupled receptors using E. coli GroEL as a molecular adjuvant in DNA immunization.

1 September 2018

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The influence of drug-like concepts on decision-making in medicinal chemistry

1 September 2018

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The calcium-sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1.

1 September 2018

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Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist

1 September 2018

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Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-o

1 September 2018

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Chemokine receptor dimerization: two are better than one.

1 September 2018

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The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies

1 September 2018

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Allosteric Modulation of G Protein–Coupled Receptors

1 September 2018

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Crossref

https://api.crossref.org/works/10.4161%2FMABS.27226

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

21 January 2018

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Crossref

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First report of anti-calcium-sensing receptor antibodies in a patient with Sjogren's syndrome and primary hypoparathyroidism

21 January 2018

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12 December 2020

[Antibodies against the second extracellular loop of beta1-adrenergic receptor induce aortic endothelial dysfunction in Wistar rat]

1 reference

12 December 2020

Administration of the cyclic peptide COR-1 in humans (phase I study): ex vivo measurements of anti-β1-adrenergic receptor antibody neutralization and of immune parameters

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12 December 2020

Mechanism of GPCR-directed autoantibodies in diseases

1 reference

12 December 2020

Interaction between autoantibodies against the beta1-adrenoceptor and isoprenaline in enhancing L-type Ca2+ current in rat ventricular myocytes

1 reference

12 December 2020

Antibodies to cardiac receptors

1 reference

12 December 2020

Biopharmaceutical benchmarks 2010

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12 December 2020

Modulation of beta1-adrenoceptor activity by domain-specific antibodies and heart failure-associated autoantibodies

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12 December 2020

Modification of the binding properties of muscarinic receptors by gallamine

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12 December 2020

Identifiers

DOI

10.4161/MABS.27226

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24253107%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24253107%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

24253107

1 reference