Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. (Q37594746)

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4 January 2020

title

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development (English)

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4 January 2020

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7

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4 January 2020

author name string

Nicholas W Gale

1

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4 January 2020

Melissa G Dominguez

2

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4 January 2020

Irene Noguera

3

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4 January 2020

Li Pan

4

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4 January 2020

Virginia Hughes

5

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4 January 2020

David M Valenzuela

6

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Niels C Adams

8

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4 January 2020

Hsin Chieh Lin

9

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4 January 2020

Jocelyn Holash

10

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4 January 2020

Gavin Thurston

11

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4 January 2020

George D Yancopoulos

12

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4 January 2020

language of work or name

English

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publication date

1 November 2004

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Proceedings of the National Academy of Sciences of the United States of America

4 January 2020

published in

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volume

101

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4 January 2020

issue

45

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4 January 2020

page(s)

15949-15954

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Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

4 January 2020

cites work

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The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

23 August 2017

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Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications

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Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis

23 August 2017

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VEGF-Trap: a VEGF blocker with potent antitumor effects

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

23 August 2017

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Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis

23 August 2017

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Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation

23 August 2017

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Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells

23 August 2017

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Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization.

23 August 2017

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Notch signaling is essential for vascular morphogenesis in mice

23 August 2017

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Dll4, a novel Notch ligand expressed in arterial endothelium

23 August 2017

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The pathophysiology of the collateral circulation (arteriogenesis).

23 August 2017

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Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development

23 August 2017

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Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4

23 August 2017

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Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

23 August 2017

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23 August 2017

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

23 August 2017

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Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

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Cardiovascular ephrinB2 function is essential for embryonic angiogenesis.

1 September 2018

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1 September 2018

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Modulating apoptosis pathways in low-grade B-cell malignancies using biological response modifiers

1 September 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0407290101

21 January 2018

Identifiers

DOI

10.1073/PNAS.0407290101

1 reference

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4 January 2020

0 references

1 reference

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4 January 2020

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