Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity? (Q37594776)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

review article

1 reference

title

Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

author name string

Barbara Forte

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Paolo Orsini

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Claudia Perrera

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Helena Posteri

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Alessandra Scolaro

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Alessia Montagnoli

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

language of work or name

English

0 references

publication date

1 October 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Patents

7 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

page(s)

1377-1400

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)

7 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Sensing DNA damage by PARP-like fingers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Toward specific functions of poly(ADP-ribose) polymerase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Sister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJ

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Chemopotentiation by PARP inhibitors in cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Involvement of Brca2 in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Brca1 controls homology-directed DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

BRCA2 is required for homology-directed repair of chromosomal breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Homologous repair of DNA damage and tumorigenesis: the BRCA connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

The relationship between the roles of BRCA genes in DNA repair and cancer predisposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

The concept of synthetic lethality in the context of anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Hallmarks of 'BRCAness' in sporadic cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Ataxia telangiectasia gene mutations in leukaemia and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

The CHEK2 gene and inherited breast cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Utilizing RNA interference to enhance cancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primar

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Ischemic and inflammatory lung impairment by extracorporeal circulation: effect of PARP-inhibition by INO1001.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Zinc binding catalytic domain of human tankyrase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Carboxamide group conformation in the nicotinamide and thiazole-4-carboxamide rings: implications for enzyme binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors in cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamide. Metabolic reduction to the 3-nitroso derivative and induction of cell death in tumor cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

The Pfam protein families database

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

Amplification of the BRCA2 Pathway Gene EMSY in Sporadic Breast Cancer Is Related to Negative Outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903215883

10.1517/13543770903215883

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19743897%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference