Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2. (Q37602035)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23712846%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2 (English)

1 reference

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2 March 2020

1 reference

5

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2 March 2020

Mingyao Liu

7

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2 March 2020

author name string

Ying Wang

1

1 reference

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2 March 2020

Jie Dong

2

1 reference

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2 March 2020

Dali Li

3

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2 March 2020

Li Lai

4

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2 March 2020

Yi Li

6

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2 March 2020

publication date

1 September 2013

1 reference

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2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23712846%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

31

1 reference

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2 March 2020

page(s)

1921-1931

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2 March 2020

issue

9

1 reference

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Lgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in mice

2 March 2020

cites work

1 reference

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Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis

23 August 2017

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

23 August 2017

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β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium

23 August 2017

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A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer

23 August 2017

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GPR48 increases mineralocorticoid receptor gene expression

23 August 2017

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23 August 2017

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

23 August 2017

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Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture

23 August 2017

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Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro

23 August 2017

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The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage

23 August 2017

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Regulation of bone formation and remodeling by G-protein-coupled receptor 48

23 August 2017

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The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development

23 August 2017

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23 August 2017

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

23 August 2017

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Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progression

23 August 2017

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Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway

23 August 2017

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Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2.

23 August 2017

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Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis

23 August 2017

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Identification of stem cells in small intestine and colon by marker gene Lgr5

23 August 2017

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Three-dimensional culture models of normal and malignant breast epithelial cells

23 August 2017

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The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis

23 August 2017

1 reference

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Deciphering the mammary epithelial cell hierarchy

23 August 2017

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Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

23 August 2017

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Defective postnatal development of the male reproductive tract in LGR4 knockout mice

23 August 2017

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Generation of a functional mammary gland from a single stem cell

23 August 2017

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Purification and unique properties of mammary epithelial stem cells

23 August 2017

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Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation

23 August 2017

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In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

23 August 2017

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Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling

23 August 2017

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Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice

23 August 2017

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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

23 August 2017

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Effects of estrogen on the proportion of stem cells in the breast.

6 September 2017

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LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

G protein-coupled receptor 48 upregulates estrogen receptor alpha expression via cAMP/PKA signaling in the male reproductive tract.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Lgr4-mediated Wnt/β-catenin signaling in peritubular myoid cells is essential for spermatogenesis.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Conditional knockout of Lgr4 leads to impaired ductal elongation and branching morphogenesis in mouse mammary glands.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Smad, PI3K/Akt, and Wnt-dependent signaling pathways are involved in BMP-4-induced ESC self-renewal.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

GPR48 regulates epithelial cell proliferation and migration by activating EGFR during eyelid development

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Convergence of Wnt and FGF signals in the genesis of posterior neural plate through activation of the Sox2 enhancer N-1.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Frizzled 5 signaling governs the neural potential of progenitors in the developing Xenopus retina.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Prolactin controls mammary gland development via direct and indirect mechanisms.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3934111

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23712846

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/STEM.1438

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23712846%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23712846%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference