A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma. (Q37619840)

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scientific article published on 24 February 2014

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English	A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma.	scientific article published on 24 February 2014

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8 March 2020

A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma (English)

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8 March 2020

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Patrick M Reeves

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8 March 2020

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Jianping Yuan

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Satoshi Kashiwagi

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Jean Nezivar

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Yuan Yang

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Nadiah Hashim Arrifin

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8 March 2020

Mai Nguyen

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Gilberte Jean-Mary

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Xiaoyun Tong

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Paramjit Uppal

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Svetlana Korochkina

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8 March 2020

Ben Forbes

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Tao Chen

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Roderick Bronson

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Huabiao Chen

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Sandra Orsulic

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8 March 2020

Timothy Brauns

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Pierre Leblanc

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Nathalie Scholler

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8 March 2020

Glenn Dranoff

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Jeffrey Gelfand

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Mark C Poznansky

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8 March 2020

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24 February 2014

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8 March 2020

Journal of Hematology & Oncology

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8 March 2020

15

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8 March 2020

describes a project that uses

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23 August 2017

The role of mesothelin in tumor progression and targeted therapy

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Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice

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Redirected antitumor activity of primary human lymphocytes transduced with a fully human anti-mesothelin chimeric receptor

1 reference

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CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer.

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Kinetics of host cell recruitment during dissemination of diffuse malignant peritoneal mesothelioma

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The human cancer antigen mesothelin is more efficiently presented to the mouse immune system when targeted to the DEC-205/CD205 receptor on dendritic cells

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23 August 2017

Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P.

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A mouse model for the molecular characterization of brca1-associated ovarian carcinoma

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Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE).

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Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers

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Mesothelin expression in human lung cancer

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Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/24565018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mycobacterium tuberculosis heat-shock protein 70 impairs maturation of dendritic cells from bone marrow precursors, induces interleukin-10 production and inhibits T-cell proliferation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/24565018

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based on heuristic

inferred from PubMed ID database lookup

Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24565018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of recombinant heat shock protein 70 of mycobacterial origin on cytotoxic activity and immunophenotype of human peripheral blood mononuclear leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24565018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel vaccine strategy to induce mycobacterial antigen-specific Th1 responses by utilizing the C-terminal domain of heat shock protein 70

1 reference

https://pubmed.ncbi.nlm.nih.gov/24565018

12 December 2020

based on heuristic

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10.1186/1756-8722-7-15

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8 March 2020

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8 March 2020

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8 March 2020

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