Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment. (Q37621828)

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11 February 2020

review article

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title

Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment (English)

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8

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Sunil R Hingorani

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Margaret Tempero

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11 February 2020

author name string

Philip A Philip

1

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Margaret Mooney

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Deborah Jaffe

3

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Gail Eckhardt

4

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Malcolm Moore

5

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Neal Meropol

6

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Leisha Emens

7

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Murray Korc

9

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Lee Ellis

10

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Jacqueline Benedetti

11

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Mace Rothenberg

12

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Christopher Willett

13

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Andrew Lowy

15

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James Abbruzzese

16

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Diane Simeone

17

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Jordan Berlin

19

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Joel Tepper

20

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language of work or name

English

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publication date

26 October 2009

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Journal of Clinical Oncology

11 February 2020

published in

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volume

27

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issue

33

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page(s)

5660-5669

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Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

11 February 2020

cites work

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A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer

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Comparing an experimental agent to a standard agent: relative merits of a one-arm or randomized two-arm Phase II design

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A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

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K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster

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An in vivo platform for translational drug development in pancreatic cancer

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Design issues of randomized phase II trials and a proposal for phase II screening trials

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Aurora-B/AIM-1 kinase activity is involved in Ras-mediated cell transformation.

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Genomic alterations in distal bile duct carcinoma by comparative genomic hybridization and karyotype analysis

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12 December 2020

Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation

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Mechanism of third signals provided by IL-12 and OX-40R ligation in eliciting therapeutic immunity following dendritic-tumor fusion vaccination

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12 December 2020

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

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12 December 2020

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

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12 December 2020

Cancer-associated stromal fibroblasts promote pancreatic tumor progression

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Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials

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12 December 2020

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

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Farnesyltransferase inhibitors as anticancer agents: current status.

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Anti-cytotoxic T-lymphocyte antigen-4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment

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12 December 2020

Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation

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12 December 2020

Postresection CA 19-9 predicts overall survival in patients with pancreatic cancer treated with adjuvant chemoradiation: a prospective validation by RTOG 9704

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12 December 2020

Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition

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Effect of gemcitabine on immune cells in subjects with adenocarcinoma of the pancreas

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12 December 2020

Borderline resectable pancreatic cancer: the importance of this emerging stage of disease.

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12 December 2020

Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia

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Ras family signaling: therapeutic targeting

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Development and characterization of gemcitabine-resistant pancreatic tumor cells.

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Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

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Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer

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Genetics and biology of pancreatic ductal adenocarcinoma.

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12 December 2020

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

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12 December 2020

Biotherapeutic approaches to pancreatic cancer

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Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway

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12 December 2020

Pancreatic stellate cells: partners in crime with pancreatic cancer cells

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12 December 2020

Neoadjuvant therapy for pancreatic cancer

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12 December 2020

Pancreatic cancer-associated stroma production

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12 December 2020

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

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12 December 2020

Human pancreatic cancer stem cells: implications for how we treat pancreatic cancer

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Tumor immunotherapy: preclinical and clinical activity of anti-CTLA4 antibodies

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Chemotherapy and tumor immunity: an unexpected collaboration

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Development of a cytokine-modified allogeneic whole cell pancreatic cancer vaccine.

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Tumor-stroma interactions in pancreatic ductal adenocarcinoma

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Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

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Inflammatory mechanisms contributing to pancreatic cancer development

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Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

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Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

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12 December 2020

Identification of pancreatic cancer stem cells

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12 December 2020

Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition

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12 December 2020

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

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12 December 2020

Lately, it occurs to me what a long, strange trip it's been for the farnesyltransferase inhibitors

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12 December 2020

Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts

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12 December 2020

Pancreatic cancer stem cells: implications for the treatment of pancreatic cancer

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12 December 2020

Detection of circulating tumor cells in patients with pancreatic cancer: a preliminary result

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12 December 2020

Identifiers

DOI

10.1200/JCO.2009.21.9022

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11 February 2020

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