An industry perspective on the utility of short-term carcinogenicity testing in transgenic mice in pharmaceutical development (Q37628343)

21 August 2017

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title

An industry perspective on the utility of short-term carcinogenicity testing in transgenic mice in pharmaceutical development (English)

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21 August 2017

Richard D Storer

1

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21 August 2017

Frank D Sistare

series ordinal

2

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21 August 2017

M Vijayaraj Reddy

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3

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21 August 2017

Joseph J DeGeorge

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4

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21 August 2017

language of work or name

English

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publication date

5 November 2009

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21 August 2017

published in

Toxicologic Pathology

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21 August 2017

volume

38

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21 August 2017

issue

1

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21 August 2017

page(s)

51-61

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Cancer in rodents: does it tell us about cancer in humans?

21 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Expectations for transgenic rodent cancer bioassay models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Alternative models for carcinogenicity testing: weight of evidence evaluations across models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Hemangiosarcoma in rodents: mode-of-action evaluation and human relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

21 January 2018

Cancer: off by a whisker

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

The p53-deficient mouse: a model for basic and applied cancer studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Tg.AC genetically altered mouse: assay working group overview of available data

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Modelling the molecular circuitry of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Commentary: regulatory toxicology and the critical path: predicting long-term outcomes from short-term studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

p53 protects against skin cancer induction by UV-B radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

UV irradiation augments lymphoid malignancies in mice with one functional copy of wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Carcinogenic susceptibility of rasH2 mice to troglitazone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Application of comparative functional genomics to identify best-fit mouse models to study human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

The utility of genetically modified mouse assays for identifying human carcinogens: a basic understanding and path forward. The Alternatives to Carcinogenicity Testing Committee ILSI HESI

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Neonatal mouse model: review of methods and results

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analyses of the induced tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Pathological features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for six-month carcinogenicity studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

The Tg rasH2 mouse in cancer hazard identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Susceptibilities of p53 knockout and rasH2 transgenic mice to urethane-induced lung carcinogenesis are inherited from their original strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Intracisternal A particle genes: Distribution in the mouse genome, active subtypes, and potential roles as species-specific mediators of susceptibility to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Background and framework for ILSI's collaborative evaluation program on alternative models for carcinogenicity assessment. International Life Sciences Institute

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Chemically induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-Ha-ras gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Responses of transgenic mouse lines p53(+/-) and Tg.AC to agents tested in conventional carcinogenicity bioassays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

P53+/- hemizygous knockout mouse: overview of available data

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Chemical effects in transgenic mice bearing oncogenes expressed in mammary tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

The Tg.AC (v-Ha-ras) transgenic mouse: nature of the model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Loss of critical palindromic transgene promoter sequence in chemically induced Tg.AC mouse skin papillomas expressing transgene-derived mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Specific genomic alterations in rat renal cell carcinomas induced by N-ethyl-N-hydroxyethylnitrosamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

CB6F1-rasH2 mouse: overview of available data

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Mammary tumor induction and premature ovarian failure in ApcMin mice are not enhanced by Brca2 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

DNA repair-deficient Xpa and Xpa/p53+/- knock-out mice: nature of the models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623309351718

21 January 2018

Identifiers

DOI

10.1177/0192623309351718

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21 August 2017

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