Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. (Q37636887)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8633069%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

title

Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity (English)

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16 October 2019

2

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16 October 2019

Peter Howley

7

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16 October 2019

author name string

S N Khleif

1

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16 October 2019

C L Yee

3

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16 October 2019

G A Otterson

4

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16 October 2019

F J Kaye

5

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16 October 2019

J R Nevins

6

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16 October 2019

language of work or name

English

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publication date

1 April 1996

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16 October 2019

number of pages

5

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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16 October 2019

volume

93

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16 October 2019

page(s)

4350-4354

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16 October 2019

issue

9

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The retinoblastoma protein as a transcriptional repressor

16 October 2019

cites work

1 reference

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Cyclin D1 is a nuclear protein required for cell cycle progression in G1

23 August 2017

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Physical interaction of the retinoblastoma protein with human D cyclins

23 August 2017

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Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

23 August 2017

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Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

23 August 2017

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

23 August 2017

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A cell cycle regulator potentially involved in genesis of many tumor types

23 August 2017

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Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

23 August 2017

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D-type cyclin-dependent kinase activity in mammalian cells

23 August 2017

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23 August 2017

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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

23 August 2017

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Mutations and altered expression of p16INK4 in human cancer.

23 August 2017

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Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb.

23 August 2017

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Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4

23 August 2017

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Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

23 August 2017

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Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity.

23 August 2017

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The retinoblastoma protein and cell cycle control

23 August 2017

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

23 August 2017

1 reference

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Cloning and characterization of murine p16INK4a and p15INK4b genes

23 August 2017

1 reference

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Growth suppression by p16ink4 requires functional retinoblastoma protein

23 August 2017

1 reference

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Differentiation of human epidermal cells transformed by SV40.

23 August 2017

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Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines

23 August 2017

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Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

23 August 2017

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Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product

23 August 2017

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

23 August 2017

1 reference

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The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

23 August 2017

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Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma

23 August 2017

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Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

23 August 2017

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

23 August 2017

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A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding

23 August 2017

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Cyclin A and the retinoblastoma gene product complex with a common transcription factor

23 August 2017

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The E2F transcription factor is a cellular target for the RB protein

23 August 2017

1 reference

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Characterization of a novel human papillomavirus DNA in the cervical carcinoma cell line ME180

23 August 2017

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The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

23 August 2017

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Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

23 August 2017

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E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

23 August 2017

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Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

23 August 2017

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Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

23 August 2017

1 reference

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The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39540

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

6 September 2017

1 reference

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DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

14 September 2017

1 reference

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Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product

28 September 2017

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Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.

28 September 2017

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Cyclin-dependent regulation of G1 in mammalian fibroblasts.

28 September 2017

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Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts

25 June 2018

1 reference

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Mechanism of active transcriptional repression by the retinoblastoma protein

25 June 2018

1 reference

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Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

25 June 2018

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Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

25 June 2018

1 reference

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Association of human papillomavirus types 16 and 18 E6 proteins with p53.

25 June 2018

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Identification of a growth suppression domain within the retinoblastoma gene product

25 June 2018

1 reference

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Retinoblastoma protein switches the E2F site from positive to negative element

25 June 2018

1 reference

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Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung

25 June 2018

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12 December 2020

Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB

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12 December 2020

Rates of p16 (MTS1) mutations in primary tumors with 9p loss

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12 December 2020

P16 gene in uncultured tumours

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12 December 2020

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity

1 reference

12 December 2020

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

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12 December 2020

The ins and outs of RB: coupling gene expression to the cell cycle clock

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12 December 2020

Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product

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12 December 2020

Identifiers

DOI

10.1073/PNAS.93.9.4350

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8633069%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8633069%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

1 reference