Cardiovascular effects of relaxin: from basic science to clinical therapy (Q37638152)

21 August 2017

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title

Cardiovascular effects of relaxin: from basic science to clinical therapy (English)

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21 August 2017

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Ross A D Bathgate

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21 August 2017

Roger J Summers

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Anthony M Dart

object named as

Anthony M Dart

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4

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author name string

Xiao-Jun Du

series ordinal

1

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21 August 2017

Chrishan S Samuel

series ordinal

3

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21 August 2017

language of work or name

English

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publication date

24 November 2009

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Nature Reviews Cardiology

21 August 2017

published in

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21 August 2017

volume

7

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21 August 2017

issue

1

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21 August 2017

page(s)

48-58

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Relaxin's physiological roles and other diverse actions

21 August 2017

cites work

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Relaxin increases secretion of tissue inhibitor of matrix metalloproteinase-1 and -2 during uterine and cervical growth and remodeling in the pig

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Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women

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Activation of orphan receptors by the hormone relaxin

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International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides

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Modulation of insulin action.

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New insights into the evolution of the relaxin-LGR signaling system

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The relaxin receptor-binding site geometry suggests a novel gripping mode of interaction

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The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7

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Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).

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H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2

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Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules

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Defining the LGR8 residues involved in binding insulin-like peptide 3.

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The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors

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The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation

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Phosphoinositide 3-kinase activity is required for biphasic stimulation of cyclic adenosine 3',5'-monophosphate by relaxin

31 March 2020

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Relaxin stimulates protein kinase C zeta translocation: requirement for cyclic adenosine 3',5'-monophosphate production

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Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains.

31 March 2020

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Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin

31 March 2020

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RXFP1 couples to the Galpha-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail.

31 March 2020

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Relaxin peptides are new global players.

31 March 2020

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Relaxin activates the MAP kinase pathway in human endometrial stromal cells

31 March 2020

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Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes.

31 March 2020

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Demonstration of a relaxin receptor and relaxin-stimulated tyrosine phosphorylation in human lower uterine segment fibroblasts

31 March 2020

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Emerging role of relaxin in renal and cardiovascular function

31 March 2020

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Protective effects of relaxin in ischemia/reperfusion-induced intestinal injury due to splanchnic artery occlusion

31 March 2020

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Effect of relaxin on myocardial ischemia injury induced by isoproterenol

31 March 2020

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Relaxin as an additional protective substance in preserving and reperfusion solution for liver transplantation, shown in a model of isolated perfused rat liver

31 March 2020

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Novel drug development opportunity for relaxin in acute myocardial infarction: evidences from a swine model

31 March 2020

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Relaxin inhibits lipopolysaccharide‐induced adhesion of neutrophils to coronary endothelial cells by a nitric oxide‐mediated mechanism

31 March 2020

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Relaxin up-regulates inducible nitric oxide synthase expression and nitric oxide generation in rat coronary endothelial cells

31 March 2020

1 reference

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Relaxin counteracts myocardial damage induced by ischemia-reperfusion in isolated guinea pig hearts: evidence for an involvement of nitric oxide

31 March 2020

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Relaxin-induced increased coronary flow through stimulation of nitric oxide production.

31 March 2020

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Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway.

31 March 2020

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Relaxin-induced reduction of infarct size in male rats receiving MCAO is dependent on nitric oxide synthesis and not estrogenic mechanisms

31 March 2020

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Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB.

31 March 2020

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Evidence against the hypothesis that endothelial endothelin B receptor expression is regulated by relaxin and pregnancy

31 March 2020

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Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist.

31 March 2020

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RXFP1-inactive relaxin activates human glucocorticoid receptor: further investigations into the relaxin-GR pathway

31 March 2020

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Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics.

31 March 2020

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The vascular actions of relaxin

31 March 2020

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Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart?

31 March 2020

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Relaxin increases cardiac output and reduces systemic arterial load in hypertensive rats.

31 March 2020

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Recombinant human relaxin reduces hypoxic pulmonary hypertension in the rat.

31 March 2020

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Chronic decrease of blood pressure by rat relaxin in spontaneously hypertensive rats

31 March 2020

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Mechanisms of renal vasodilation and hyperfiltration during pregnancy

31 March 2020

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Renal function during normal pregnancy and preeclampsia

31 March 2020

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Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: sex dependency and dose response.

31 March 2020

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Intravenous recombinant human relaxin in compensated heart failure: a safety, tolerability, and pharmacodynamic trial.

31 March 2020

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Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling.

31 March 2020

1 reference

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Central hemodynamic effects of recombinant human relaxin in the isolated, perfused rat heart model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Cardiac effects of relaxin in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Relaxin increases rat heart rate by a direct action on the cardiac atrium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Comparison of relaxin receptors in rat isolated atria and uterus by use of synthetic and native relaxin analogues.

31 March 2020

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Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterization and effects of oestrogen treatment

31 March 2020

1 reference

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Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy

31 March 2020

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Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis

31 March 2020

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Functional and histopathological improvement of the post-infarcted rat heart upon myoblast cell grafting and relaxin therapy.

31 March 2020

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Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype.

31 March 2020

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Reversal of cardiac fibrosis and related dysfunction by relaxin.

31 March 2020

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31 March 2020

Regenerating the heart

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Morphofunctional integration between skeletal myoblasts and adult cardiomyocytes in coculture is favored by direct cell-cell contacts and relaxin treatment

31 March 2020

1 reference

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Skeletal myoblasts overexpressing relaxin improve differentiation and communication of primary murine cardiomyocyte cell cultures

31 March 2020

1 reference

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The pregnancy hormone relaxin is a player in human heart failure.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

N-terminal pro B type natriuretic peptide, but not the new putative cardiac hormone relaxin, predicts prognosis in patients with chronic heart failure

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Relaxin is an independent risk factor predicting death in male patients with end-stage kidney disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Is the pregnancy hormone relaxin an important player in human heart failure?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Circulating levels of relaxin and its relation to cardiovascular function in patients with hypertension

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

The relationship between hCG and relaxin secretion in normal pregnancies vs peri-implantation spontaneous abortions

31 March 2020

1 reference

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The disposition of a human relaxin (hRlx-2) in pregnant and nonpregnant rats

31 March 2020

1 reference

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Relaxin, a pleiotropic vasodilator for the treatment of heart failure.

31 March 2020

1 reference

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Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping

31 March 2020

1 reference

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Myofibroblasts induce ectopic activity in cardiac tissue

31 March 2020

1 reference

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Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators

31 March 2020

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Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction

31 March 2020

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Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias

31 March 2020

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In vitro decidualization of human endometrial stromal cells

31 March 2020

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Relaxin activates multiple cAMP signaling pathway profiles in different target cells

31 March 2020

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Relaxin potentiates the expression of inducible nitric oxide synthase by endothelial cells from human umbilical vein in in vitro culture.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Relaxin activates the L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Time course and dose response of relaxin-mediated renal vasodilation, hyperfiltration, and changes in plasma osmolality in conscious rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of beta-arrestin recruitment.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Structural basis of allosteric ligand-receptor interactions in the insulin/relaxin peptide family: implications for other receptor tyrosine kinases and G-protein-coupled receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Dimerization and negative cooperativity in the relaxin family peptide receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Relaxin binding in the rat heart atrium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Myocardial relaxin counteracts hypertrophy in hypertensive rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCARDIO.2009.198

Structural biology of insulin and IGF-1 receptors.

31 March 2020

1 reference

12 December 2020

Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart

1 reference

12 December 2020

Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts

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12 December 2020

Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms

1 reference

12 December 2020

Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones

1 reference

12 December 2020

Relaxin prevents the development of severe acute pancreatitis

1 reference

12 December 2020

Serum relaxin in systemic sclerosis.

1 reference

12 December 2020

10.1038/NRCARDIO.2009.198

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