Improving cardiac gap junction communication as a new antiarrhythmic mechanism: the action of antiarrhythmic peptides (Q37639916)

21 August 2017

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title

Improving cardiac gap junction communication as a new antiarrhythmic mechanism: the action of antiarrhythmic peptides (English)

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21 August 2017

Stefan Dhein

1

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21 August 2017

Anja Hagen

2

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21 August 2017

Joanna Jozwiak

3

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21 August 2017

Anna Dietze

4

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21 August 2017

Jens Garbade

5

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21 August 2017

Markus Barten

6

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21 August 2017

Martin Kostelka

7

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21 August 2017

Friedrich-Wilhelm Mohr

8

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21 August 2017

27 November 2009

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Naunyn-Schmiedeberg's Archives of Pharmacology

21 August 2017

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21 August 2017

381

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21 August 2017

3

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21 August 2017

221-234

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https://scigraph.springernature.com/pub.10.1007/s00210-009-0473-1

21 August 2017

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Multiple regional differences in cellular properties that regulate repolarization and contraction in the right atrium of adult and newborn dogs.

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12 December 2020

Gap junctions and the connexin protein family

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12 December 2020

Structure-activity relationships of novel peptides related to the antiarrhythmic peptide AAP10 which reduce the dispersion of epicardial action potential duration

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12 December 2020

ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs.

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12 December 2020

Increasing gap junction coupling reduces transmural dispersion of repolarization and prevents torsade de pointes in rabbit LQT3 model

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12 December 2020

Expression of multiple connexins in cultured neonatal rat ventricular myocytes

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12 December 2020

Intrinsic heterogeneity in repolarization is increased in isolated failing rabbit cardiomyocytes during simulated ischemia

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12 December 2020

Pharmacological modification of gap junction coupling by an antiarrhythmic peptide via protein kinase C activation

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12 December 2020

Changes in phosphorylation of connexin43 in rats during acute myocardial hypoxia and effects of antiarrhythmic peptide on the phosphorylation

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12 December 2020

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12 December 2020

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12 December 2020

The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation

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12 December 2020

Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation

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12 December 2020

Intracellular Ca2+, intercellular electrical coupling, and mechanical activity in ischemic rabbit papillary muscle. Effects of preconditioning and metabolic blockade

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ATP release by cardiac myocytes in a simulated ischaemia model: inhibition by a connexin mimetic and enhancement by an antiarrhythmic peptide

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12 December 2020

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Rotigaptide (ZP123) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs

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12 December 2020

The antiarrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43.

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12 December 2020

Enhancement of ventricular gap-junction coupling by rotigaptide

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12 December 2020

Role of gap junctions in the propagation of the cardiac action potential

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12 December 2020

Local effects and mechanisms of antiarrhythmic peptide AAP10 in acute regional myocardial ischemia: electrophysiological and molecular findings

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12 December 2020

Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system

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12 December 2020

Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123).

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12 December 2020

Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions

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12 December 2020

Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction

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12 December 2020

Electrotonic interactions across an inexcitable region as a cause of ectopic activity in acute regional myocardial ischemia. A study in intact porcine and canine hearts and computer models

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12 December 2020

The gap junction communication channel

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12 December 2020

Altered pattern of connexin40 distribution in persistent atrial fibrillation in the goat

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12 December 2020

A method to determine the relative cAMP permeability of connexin channels

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12 December 2020

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12 December 2020

Increase in gap junction conductance by an antiarrhythmic peptide

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12 December 2020

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12 December 2020

Role of connexins in atrial fibrillation

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12 December 2020

Protein kinase Calpha mediates the effect of antiarrhythmic peptide on gap junction conductance

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12 December 2020

The anti-arrhythmic peptide AAP10 remodels Cx43 and Cx40 expression and function

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12 December 2020

Spatial structure determination of antiarrhythmic peptide using nuclear magnetic resonance spectroscopy

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12 December 2020

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12 December 2020

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12 December 2020

Regulation of gap junctions by phosphorylation of connexins

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12 December 2020

Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure

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12 December 2020

Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions

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12 December 2020

Treatment with the gap junction modifier rotigaptide (ZP123) reduces infarct size in rats with chronic myocardial infarction.

1 reference

12 December 2020

Pharmacological stimulation of cardiac gap junction coupling does not affect ischemia-induced focal ventricular tachycardia or triggered activity in dogs

1 reference

12 December 2020

Three-dimensional structure of a recombinant gap junction membrane channel

1 reference

12 December 2020

ATP counteracts the rundown of gap junctional channels of rat ventricular myocytes by promoting protein phosphorylation

1 reference

12 December 2020

Rotigaptide (ZP123) improves atrial conduction slowing in chronic volume overload-induced dilated atria

1 reference

12 December 2020

The life cycle of a connexin: gap junction formation, removal, and degradation.

1 reference

12 December 2020

New antiarrhythmic treatment of atrial fibrillation

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12 December 2020

Initiating reentry: the role of nonuniform anisotropy in small circuits

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12 December 2020

Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43.

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12 December 2020

The antiarrhythmic peptide analog rotigaptide (ZP123) stimulates gap junction intercellular communication in human osteoblasts and prevents decrease in femoral trabecular bone strength in ovariectomized rats.

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12 December 2020

Model-dependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs

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12 December 2020

Five-hour half-life of mouse liver gap-junction protein

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12 December 2020

Sodium channel blockade enhances dispersion of the cardiac action potential duration. A computer simulation study.

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12 December 2020

Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling

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12 December 2020

The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model.

1 reference

12 December 2020

Inhibition of gap junctional conductance by long-chain acylcarnitines and their preferential accumulation in junctional sarcolemma during hypoxia

1 reference

12 December 2020

Expression of connexin in atrium of patients with atrial fibrillation and its signal transduction pathway

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12 December 2020

Atrial fibrillation in rats induced by rapid transesophageal atrial pacing during brief episodes of asphyxia: a new in vivo model

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12 December 2020

The antiarrhythmic peptide rotigaptide (ZP123) increases connexin 43 protein expression in neonatal rat ventricular cardiomyocytes

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12 December 2020

Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol.

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12 December 2020

Fibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve disease

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12 December 2020

Activation Delay After Premature Stimulation in Chronically Diseased Human Myocardium Relates to the Architecture of Interstitial Fibrosis

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12 December 2020

Pharmacological characterization of the new stable antiarrhythmic peptide analog Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2 (ZP123): in vivo and in vitro studies

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12 December 2020

Human cardiac gap-junction coupling: effects of antiarrhythmic peptide AAP10

1 reference

12 December 2020

Gap junction alterations in human cardiac disease.

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12 December 2020

Effects of chronic atrial fibrillation on gap junction distribution in human and rat atria

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12 December 2020

Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping

1 reference

12 December 2020

Pathophysiologic mechanisms of cardiac arrhythmias

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12 December 2020

Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER.

1 reference

12 December 2020

A new antiarrhythmic peptide, N-3-(4-hydroxyphenyl)propionyl Pro-Hyp-Gly-Ala-Gly

1 reference

12 December 2020

TPA increases conductance but decreases permeability in neonatal rat cardiomyocyte gap junction channels

1 reference

12 December 2020

Flow of "injury" current and patterns of excitation during early ventricular arrhythmias in acute regional myocardial ischemia in isolated porcine and canine hearts. Evidence for two different arrhythmogenic mechanisms

1 reference

12 December 2020

Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice

1 reference

12 December 2020

Gap junctional remodeling in relation to stabilization of atrial fibrillation in the goat

1 reference

12 December 2020

Pharmacological modulation of cardiac gap junctions to enhance cardiac conduction: evidence supporting a novel target for antiarrhythmic therapy

1 reference

12 December 2020

[The relationship between gap junctional remodeling and atrial fibrillation in patients with rheumatic heart disease]

1 reference

12 December 2020

Actions of the antiarrhythmic peptide AAP10 on intercellular coupling

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12 December 2020

The antiarrhythmic peptide analog ZP123 prevents atrial conduction slowing during metabolic stress

1 reference

12 December 2020

Amiodarone: what have we learned from clinical trials?

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12 December 2020

Effects of the gap junction modifier rotigaptide (ZP123) on atrial conduction and vulnerability to atrial fibrillation

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12 December 2020

Switched single-electrode voltage-clamp amplifiers allow precise measurement of gap junction conductance

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12 December 2020

Evolutionary selection pressure and family relationships among connexin genes.

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12 December 2020

Effects of the new antiarrhythmic peptide ZP123 on epicardial activation and repolarization pattern

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12 December 2020

10.1007/S00210-009-0473-1

Identifiers

DOI

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release_ug46uqwpcveirm4bmjcj3x5j3q

21 August 2017

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https://api.fatcat.wiki/v0/release/ug46uqwpcveirm4bmjcj3x5j3q

24 November 2022

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