Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials (Q37651509)

21 August 2017

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title

Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials (English)

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21 August 2017

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Jens Lykkesfeldt

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Henrik Enghusen Poulsen

object named as

Henrik E Poulsen

series ordinal

2

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publication date

15 December 2009

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British Journal of Nutrition

21 August 2017

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21 August 2017

103

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21 August 2017

1251-1259

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21 August 2017

9

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Relation of ascorbic acid to coronary artery calcium: the Coronary Artery Risk Development in Young Adults Study

21 August 2017

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Vitamin C deficiency and depletion in the United States: the Third National Health and Nutrition Examination Survey, 1988 to 1994

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Molecular mechanism of alpha-tocopherol action

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke: Basel Prospective Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community. The Shibata study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Relation of serum ascorbic acid to mortality among US adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Oral antioxidant supplementation for fatigue associated with primary biliary cirrhosis: results of a multicentre, randomized, placebo-controlled, cross-over trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Dietary antioxidants and DNA damage in patients on long-term acid-suppression therapy: a randomized controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Vitamin C deficiency and risk of myocardial infarction: prospective population study of men from eastern Finland

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

The Roche European American Cataract Trial (REACT): a randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Vitamin C deficiency in cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Serum vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

The effect of controlled ascorbic acid depletion and supplementation on periodontal health

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Clinical effects of vitamin C in elderly inpatients with low blood-vitamin-C levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Principles involved in formulating recommendations for vitamin C intake: a paradigm for water-soluble vitamins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Importance of supplemental vitamin C in determining serum ascorbic acid in controls from a cervical cancer case-control study: implications for epidemiological studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial).

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Can a short period of micronutrient supplementation in older institutionalized people improve response to influenza vaccine? A randomized, controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Dietary intake, plasma levels of antioxidant vitamins, and oxidative stress in relation to coronary artery disease in elderly subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Carotenoids, vitamins C and E, and mortality in an elderly population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

The effect of 5-year vitamin C supplementation on serum pepsinogen level and Helicobacter pylori infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

An intervention trial to inhibit the progression of precancerous gastric lesions: compliance, serum micronutrients and S-allyl cysteine levels, and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Nutritional supplementation in elderly medical in-patients: a double-blind placebo-controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Does vitamin C deficiency result in impaired brain development in infants?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Role of marginal vitamin C deficiency in atherogenesis: in vivo models and clinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

The Effect of Dietary Supplementation with Vitamins A, C and E on Cell-mediated Immune Function in Elderly Long-stay Patients: A Randomized Controlled Trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

Plasma vitamin C and food choice in the third Glasgow MONICA population survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

The influence of smoking on vitamin C status in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Why epidemiological and clinical intervention studies often give different or diverging results?

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C.

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Relationship of plasma level of vitamin C to mortality from ischemic heart disease

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Vitamin C status and mortality in US adults

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-helicobacter pylori therapy

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. geriatric network

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

A clinical trial of antioxidant vitamins to prevent colorectal adenoma. Polyp Prevention Study Group

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

https://api.crossref.org/works/10.1017%2FS0007114509993229

1 reference

7 January 2021

Clinical manifestations of ascorbic acid deficiency in man

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Estimating ascorbic acid requirements for cigarette smokers

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

The pathophysiology of scurvy. A report of seven cases

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

The cause and correction of low blood vitamin C concentrations in the elderly.

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Determination of optimal vitamin C requirements in humans

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https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes.

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Supplement use is associated with health status and health-related behaviors in the 1946 British birth cohort

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Diet and lifestyle characteristics associated with dietary supplement use in women

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Serum levels of vitamin C in relation to dietary and supplemental intake of vitamin C in smokers and nonsmokers

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Assessment of human vitamin C status

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smoking.

1 reference

https://api.crossref.org/works/10.1017%2FS0007114509993229

7 January 2021

10.1017/S0007114509993229

Identifiers

DOI

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21 August 2017

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PubMed ID

20003627