Very long chain sphingolipids: tissue expression, function and synthesis (Q37662812)

21 August 2017

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title

Very long chain sphingolipids: tissue expression, function and synthesis (English)

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21 August 2017

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Roger Sandhoff

1

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PubMed ID

20035755

21 August 2017

language of work or name

English

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publication date

24 December 2009

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21 August 2017

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21 August 2017

584

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21 August 2017

1907-1913

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21 August 2017

9

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Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis

21 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Disruption of blood-testis barrier dynamics in ether-lipid-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

The phospholipid-bound fatty acids and aldehydes of mammalian spermatozoa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Very long chain fatty acids in higher animals--a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Molecular Species of Phosphatidylcholine Containing Very Long Chain Fatty Acids in Human Brain: Enrichment in X-Linked Adrenoleukodystrophy Brain and Diseases of Peroxisome Biogenesis Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Novel class of glycosphingolipids involved in male fertility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Complex gangliosides are essential in spermatogenesis of mice: possible roles in the transport of testosterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Rapid phase change of lipid microdomains in giant vesicles induced by conversion of sphingomyelin to ceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Barrier function of the skin: "la raison d'être" of the epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

MEMBRANE-COATING GRANULES OF KERATINIZING EPITHELIA

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Lamellar body-enriched fractions from neonatal mice: preparative techniques and partial characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal skin barrier defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Accumulation of protein-bound epidermal glucosylceramides in beta-glucocerebrosidase deficient type 2 Gaucher mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Sphingolipid activator proteins are required for epidermal permeability barrier formation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Sphingolipid metabolism during epidermal barrier development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

The glycosphingolipidoses-from disease to basic principles of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Human epidermal glucosylceramides are major precursors of stratum corneum ceramides

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Collodion babies with Gaucher's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58).

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Mammalian fatty acid elongases

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Fatty acid elongases in mammals: their regulation and roles in metabolism

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Elongation of long-chain fatty acids

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Members of the Arabidopsis FAE1-like 3-ketoacyl-CoA synthase gene family substitute for the Elop proteins of Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

A molecular caliper mechanism for determining very long-chain fatty acid length

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Role for ELOVL3 and fatty acid chain length in development of hair and skin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Biosynthesis of sphingolipids: dihydroceramide and not sphinganine is desaturated by cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Ceramide biosynthesis in keratinocyte and its role in skin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

CGI-58 is an alpha/beta-hydrolase within lipid transporting lamellar granules of differentiated keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Ceramides and Sphingomyelins with High Proportions of Very Long-chain Polyunsaturated Fatty acids in Mammalian Germ Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

Very Long-chain Polyunsaturated Fatty Acids Are the Major Acyl Groups of Sphingomyelins and Ceramides in the Head of Mammalian Spermatozoa

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

CD95 Signaling via Ceramide-rich Membrane Rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.12.032

10.1016/J.FEBSLET.2009.12.032

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

20035755