Peripheral metabolic effects of endocannabinoids and cannabinoid receptor blockade (Q37669645)

3 July 2019

review article

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title

Peripheral metabolic effects of endocannabinoids and cannabinoid receptor blockade (English)

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3 July 2019

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Stefan Engeli

1

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3 July 2019

language of work or name

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8 February 2008

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3 July 2019

published in

Obesity Facts

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3 July 2019

volume

1

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3 July 2019

page(s)

8-15

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3 July 2019

issue

1

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3 July 2019

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice

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Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice

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Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase.

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The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake.

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Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol.

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The endocannabinoid system as an emerging target of pharmacotherapy

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Central nervous system control of food intake and body weight

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Human adipose tissue cannabinoid receptor 1 gene expression is not related to fat cell function or adiponectin level

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Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury

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12 December 2020

Identification of endocannabinoids and related compounds in human fat cells

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Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase

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Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus.

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12 December 2020

Role of cannabinoid CB2 receptors in glucose homeostasis in rats

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12 December 2020

Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats

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12 December 2020

[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor

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12 December 2020

Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats

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12 December 2020

Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells

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12 December 2020

Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity

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12 December 2020

Adipose tissue macrophages.

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12 December 2020

The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3-kinase and calcium-dependent mechanisms

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12 December 2020

Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats

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12 December 2020

The endocannabinoid system and gut-brain signalling.

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12 December 2020

Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors.

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12 December 2020

The pharmacology of the cannabinoid system--a question of efficacy and selectivity

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Long term pharmacotherapy for obesity and overweight: updated meta-analysis.

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12 December 2020

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

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12 December 2020

Determination and characterization of a cannabinoid receptor in rat brain

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12 December 2020

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

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12 December 2020

Molecular characterization of a peripheral receptor for cannabinoids

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12 December 2020

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

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12 December 2020

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

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12 December 2020

cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases

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12 December 2020

Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock

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12 December 2020

Appetite suppression and weight loss after the cannabinoid antagonist SR 141716.

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12 December 2020

Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.

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12 December 2020

Identifiers

DOI

10.1159/000114255

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3 July 2019

PMCID

6444701

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3 July 2019

PubMed ID

20054157

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3 July 2019