Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential (Q37670253)

21 August 2017

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title

Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential (English)

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21 August 2017

3

Helmut Friess

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21 August 2017

2

Ihsan Ekin Demir

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21 August 2017

4

Güralp O Ceyhan

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21 August 2017

Jan G D'Haese

1

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PubMed ID

20055718

21 August 2017

language of work or name

English

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publication date

1 February 2010

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Expert Opinion on Therapeutic Targets

21 August 2017

13

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based on heuristic

inferred from page(s)

published in

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21 August 2017

14

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21 August 2017

2

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21 August 2017

207-219

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Chemokines: a new classification system and their role in immunity

21 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

A new class of membrane-bound chemokine with a CX3C motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Tumor necrosis factor-alpha-converting enzyme mediates the inducible cleavage of fractalkine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Chemokines in the CNS: plurifunctional mediators in diverse states

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Fractalkine and TGF-beta1 levels reflect the severity of chronic pancreatitis in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Tissue-specific differential antitumour effect of molecular forms of fractalkine in a mouse model of metastatic colon cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

CD4-independent infection by HIV-2 (ROD/B): use of the 7-transmembrane receptors CXCR-4, CCR-3, and V28 for entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Fractalkine upregulates intercellular adhesion molecule-1 in endothelial cells through CX3CR1 and the Jak Stat5 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Leukocyte influx in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, is elevated in coronary artery disease and is reduced during statin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Role of the fractalkine receptor CX3CR1 polymorphisms V249I and T280M as risk factors for early-onset coronary artery disease in patients with no classic risk factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Chemokine receptor CX3CR1 regulates renal interstitial fibrosis after ischemia-reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Expression and targeting of CX3CL1 (fractalkine) in renal tubular epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Antagonist of fractalkine (CX3CL1) delays the initiation and ameliorates the progression of lupus nephritis in MRL/lpr mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Control of microglial neurotoxicity by the fractalkine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Immune cell involvement in dorsal root ganglia and spinal cord after chronic constriction or transection of the rat sciatic nerve.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Intra-neural administration of fractalkine attenuates neuropathic pain-related behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

New evidence for the involvement of spinal fractalkine receptor in pain facilitation and spinal glial activation in rat model of monoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

The chemokine CX3CL1/fractalkine interferes with the antinociceptive effect induced by opioid agonists in the periaqueductal grey of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Viral macrophage inflammatory protein-II and fractalkine (CX3CL1) chimeras identify molecular determinants of affinity, efficacy, and selectivity at CX3CR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

In vivo inhibition of CC and CX3C chemokine-induced leukocyte infiltration and attenuation of glomerulonephritis in Wistar-Kyoto (WKY) rats by vMIP-II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

The liberation of fractalkine in the dorsal horn requires microglial cathepsin S.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

An engineered CX3CR1 antagonist endowed with anti-inflammatory activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Gene therapy with CX3CL1/Fractalkine induces antitumor immunity to regress effectively mouse hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Chemoattraction, adhesion and activation of natural killer cells are involved in the antitumor immune response induced by fractalkine/CX3CL1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Fractalkine-CX3CR1 axis regulates tumor cell cycle and deteriorates prognosis after radical resection for hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Fractalkine gene therapy for neuroblastoma is more effective in combination with targeted IL-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Fractalkine (CX3CL1)- and interleukin-2-enriched neuroblastoma microenvironment induces eradication of metastases mediated by T cells and natural killer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Chemokine markers predict biochemical recurrence of prostate cancer following prostatectomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Effect of pro-inflammatory cytokine stimulation on human breast cancer: implications of chemokine receptor expression in cancer metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Pancreatic neuropathy and neuropathic pain--a comprehensive pathomorphological study of 546 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Pancreatic neuropathy results in "neural remodeling" and altered pancreatic innervation in chronic pancreatitis and pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Dual role of CCR2 during initiation and progression of collagen-induced arthritis: evidence for regulatory activity of CCR2+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

CC chemokine ligand 5/RANTES chemokine antagonists aggravate glomerulonephritis despite reduction of glomerular leukocyte infiltration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Species selectivity of a small molecule antagonist for the CCR1 chemokine receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Generation and analysis of mice lacking the chemokine fractalkine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

Neuronal chemokines: versatile messengers in central nervous system cell interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903540265

10.1517/14728220903540265

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

20055718