Update on von Willebrand factor multimers: focus on high-molecular-weight multimers and their role in hemostasis (Q37671400)

21 August 2017

3 references

22 April 2019

27 November 2019

21 January 2024

Update on von Willebrand factor multimers: focus on high-molecular-weight multimers and their role in hemostasis (English)

1 reference

21 August 2017

von Willebrand's disease

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22 April 2019

27 November 2019

1 reference

27 November 2019

Reinhard Schneppenheim

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Reinhard Schneppenheim

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Ulrich Budde

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3

object named as

Ulrich Budde

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author name string

Marcus Stockschlaeder

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1

1 reference

PMC publication ID

3969155

21 August 2017

language of work or name

1 reference

1 April 2014

4 references

21 August 2017

22 April 2019

27 November 2019

21 January 2024

11

1 reference

Blood Coagulation and Fibrinolysis

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published in

4 references

21 August 2017

22 April 2019

27 November 2019

21 January 2024

25

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21 August 2017

3

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21 August 2017

206-216

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

21 August 2017

3 references

22 April 2019

27 November 2019

on focus list of Wikimedia project

21 January 2024

ScienceSource

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cites work

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Structural basis of type 2A von Willebrand disease investigated by molecular dynamics simulations and experiments

23 August 2017

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Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice

23 August 2017

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Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis

23 August 2017

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N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress.

23 August 2017

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Shear stress-induced unfolding of VWF accelerates oxidation of key methionine residues in the A1A2A3 region.

23 August 2017

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Disulfide bond reduction of von Willebrand factor by ADAMTS-13.

23 August 2017

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Structure and function of a recombinant von Willebrand factor drug candidate

23 August 2017

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Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress

23 August 2017

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The genetic basis of von Willebrand disease

23 August 2017

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The mutation N528S in the von Willebrand factor (VWF) propeptide causes defective multimerization and storage of VWF.

23 August 2017

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The balance between von-Willebrand factor and its cleaving protease ADAMTS13: biomarker in systemic inflammation and development of organ failure?

23 August 2017

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The function of ADAMTS13 in thrombogenesis in vivo: insights from mutant mice

23 August 2017

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Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings

23 August 2017

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von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke

23 August 2017

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von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size.

23 August 2017

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Factor VIII and von Willebrand factor interaction: biological, clinical and therapeutic importance

23 August 2017

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Platelet alpha-granules: basic biology and clinical correlates

23 August 2017

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Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition

23 August 2017

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Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients

23 August 2017

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Diagnosis of von Willebrand disease subtypes: implications for treatment

23 August 2017

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Function of von Willebrand factor in haemostasis and thrombosis

23 August 2017

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ADAMTS13: a new link between thrombosis and inflammation.

23 August 2017

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Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.

23 August 2017

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Acquired von Willebrand syndrome: is it an extremely rare disorder or do we see only the tip of the iceberg?

23 August 2017

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Diagnostic workup of patients with acquired von Willebrand syndrome: a retrospective single-centre cohort study

23 August 2017

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Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress

23 August 2017

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The role of von Willebrand factor in thrombus formation

23 August 2017

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Von Willebrand disease - phenotype versus genotype: deficiency versus disease

23 August 2017

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Shear-induced unfolding triggers adhesion of von Willebrand factor fibers

23 August 2017

1 reference

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New insights into the coagulopathy of liver disease and liver transplantation

23 August 2017

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Acquired von Willebrand syndrome: an update

23 August 2017

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Immune-mediated etiology of acquired von Willebrand syndrome in systemic lupus erythematosus and in benign monoclonal gammopathy: therapeutic implications

23 August 2017

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Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor

23 August 2017

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Gastrointestinal bleeding in von Willebrand disease

23 August 2017

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Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure.

23 August 2017

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The evolving classification of von Willebrand disease

23 August 2017

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Management of von Willebrand disease with factor VIII/von Willebrand factor concentrates: results from current studies and surveys

23 August 2017

1 reference

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Treatment of von Willebrand's Disease

23 August 2017

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Gastrointestinal bleeding, angiodysplasia, cardiovascular disease, and acquired von Willebrand syndrome

23 August 2017

1 reference

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Laboratory diagnosis of congenital von Willebrand disease

23 August 2017

1 reference

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Functional self-association of von Willebrand factor during platelet adhesion under flow

23 August 2017

1 reference

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Appropriate laboratory assessment as a critical facet in the proper diagnosis and classification of von Willebrand disorder

23 August 2017

1 reference

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Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura

23 August 2017

1 reference

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Control of von Willebrand factor multimer size by thrombospondin-1.

23 August 2017

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Acquired von Willebrand syndrome: data from an international registry.

23 August 2017

1 reference

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Structure and function of von Willebrand factor.

23 August 2017

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Optimizing therapy with factor VIII/von Willebrand factor concentrates in von Willebrand disease

23 August 2017

1 reference

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Biochemistry and genetics of von Willebrand factor

23 August 2017

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Intracellular trafficking of factor VIII to von Willebrand factor storage granules

23 August 2017

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Shear-dependent changes in the three-dimensional structure of human von Willebrand factor

23 August 2017

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Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor

23 August 2017

1 reference

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23 August 2017

von Willebrand factor

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Triplet structure of von Willebrand factor reflects proteolytic degradation of high molecular weight multimers

23 August 2017

1 reference

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Shear stress enhances the proteolysis of von Willebrand factor in normal plasma

23 August 2017

1 reference

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Electron microscopy of human factor VIII/Von Willebrand glycoprotein: effect of reducing reagents on structure and function

23 August 2017

1 reference

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Variant von Willebrand's disease: characterization of two subtypes by analysis of multimeric composition of factor VIII/von Willebrand factor in plasma and platelets

23 August 2017

1 reference

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Platelet aggregation induced by 1-desamino-8-D-arginine vasopressin (DDAVP) in Type IIB von Willebrand's disease

23 August 2017

1 reference

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Synthesis of Antihemophilic Factor Antigen by Cultured Human Endothelial Cells

23 August 2017

1 reference

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Construction of cDNA coding for human von Willebrand factor using antibody probes for colony-screening and mapping of the chromosomal gene.

23 August 2017

1 reference

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Molecular cloning of cDNA for human von Willebrand factor: authentication by a new method

23 August 2017

1 reference

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Amino acid sequence of human von Willebrand factor

23 August 2017

1 reference

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Divergent fates of von Willebrand factor and its propolypeptide (von Willebrand antigen II) after secretion from endothelial cells

23 August 2017

1 reference

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Changes in cytosolic Ca2+ associated with von Willebrand factor release in human endothelial cells exposed to histamine. Study of microcarrier cell monolayers using the fluorescent probe indo-1.

23 August 2017

1 reference

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Fibrin induces release of von Willebrand factor from endothelial cells

23 August 2017

1 reference

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Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation

23 August 2017

1 reference

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Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE).

23 August 2017

1 reference

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Inducible secretion of large, biologically potent von Willebrand factor multimers

23 August 2017

1 reference

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Cloning and characterization of two cDNAs coding for human von Willebrand factor.

23 August 2017

1 reference

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Structure of the gene for human von Willebrand factor

23 August 2017

1 reference

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Synthesis of Factor VIII Antigen by Cultured Guinea Pig Megakaryocytes

23 August 2017

1 reference

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Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's disease

23 August 2017

1 reference

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The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story.

23 August 2017

1 reference

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The pathophysiology of von Willebrand disease: therapeutic implications

6 September 2017

1 reference

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Local elongation of endothelial cell-anchored von Willebrand factor strings precedes ADAMTS13 protein-mediated proteolysis

6 September 2017

1 reference

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Cell biology of von Willebrand factor

6 September 2017

1 reference

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Differential sensitivity of von Willebrand factor (VWF) 'activity' assays to large and small VWF molecular weight forms: a cross-laboratory study comparing ristocetin cofactor, collagen-binding and mAb-based assays

6 September 2017

1 reference

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Laboratory testing for von Willebrand disease: contribution of multimer analysis to diagnosis and classification

14 September 2017

1 reference

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The factor VIII complex: structure and function.

14 September 2017

1 reference

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Von Willebrand factor: molecular size and functional activity

14 September 2017

1 reference

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Covalent regulation of ULVWF string formation and elongation on endothelial cells under flow conditions

28 September 2017

1 reference

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Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion.

25 June 2018

1 reference

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Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization.

25 June 2018

1 reference

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von Willebrand factor released from Weibel-Palade bodies binds more avidly to extracellular matrix than that secreted constitutively

25 June 2018

1 reference

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Binding of von Willebrand factor to glycoproteins Ib and IIb/IIIa complex: affinity is related to multimeric size

25 June 2018

1 reference

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Complement proteins C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to the cell surface

25 June 2018

1 reference

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Induction of specific storage organelles by von Willebrand factor propolypeptide

25 June 2018

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Mechanical activation of a multimeric adhesive protein through domain conformational change.

25 June 2018

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Malignant malaria and microangiopathies: merging mechanisms

1 September 2018

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ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969155

Classification of inherited von Willebrand disease and implications in clinical practice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969155

Restoration of plasma von Willebrand factor deficiency is sufficient to correct thrombus formation after gene therapy for severe von Willebrand disease

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969155

Correction of bleeding symptoms in von Willebrand factor-deficient mice by liver-expressed von Willebrand factor mutants.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969155

Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969155

Differential kinetics of cell surface loss of von Willebrand factor and its propolypeptide after secretion from Weibel-Palade bodies in living human endothelial cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969155

Aspects of hydrodynamic shear regulating shear-induced platelet activation and self-association of von Willebrand factor in suspension

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969155

Biochemistry. Force signaling in biology

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3969155

Proteolytic cleavage of recombinant type 2A von Willebrand factor mutants R834W and R834Q: inhibition by doxycycline and by monoclonal antibody VP-1

2 October 2018

1 reference

12 December 2020

Effect of multimeric structure of the factor VIII/von Willebrand factor protein on binding to platelets

1 reference

12 December 2020

Platelet adhesion to collagen in subtypes of type I von Willebrand's disease is dependent on platelet von Willebrand factor

1 reference

12 December 2020

The von Willebrand factor self-association is modulated by a multiple domain interaction

1 reference

12 December 2020

Multimeric composition of endothelial cell-derived von Willebrand factor

1 reference

12 December 2020

Effect of multimerization of human and recombinant von Willebrand factor on platelet aggregation, binding to collagen and binding of coagulation factor VIII

1 reference

12 December 2020

Platelet von Willebrand factor: an important determinant of the bleeding time in type I von Willebrand's disease

1 reference

12 December 2020

Hemostasis in patients with severe von Willebrand disease improves after normal platelet transfusion and normalizes with further correction of the plasma defect

1 reference

12 December 2020

Native conformation of human von Willebrand protein. Analysis by electron microscopy and quasi-elastic light scattering

1 reference

12 December 2020

Clinical problem-solving. A bloody mystery

1 reference

12 December 2020

Haemolytic-uraemic syndrome and thrombotic thrombocytopenic purpura--new insights into underlying biochemical mechanisms

1 reference

12 December 2020

Thrombin-mediated release of factor VIII antigen from human umbilical vein endothelial cells in culture

1 reference

12 December 2020

Multimeric composition of factor VIII/von Willebrand factor following administration of DDAVP: implications for pathophysiology and therapy of von Willebrand's disease subtypes

1 reference

12 December 2020

Association between reduced ADAMTS13 and diabetic nephropathy

1 reference

12 December 2020

Heightened interaction between platelets and factor VIII/von Willebrand factor in a new subtype of von Willebrand's disease

1 reference

12 December 2020

Inflammation-associated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor

1 reference

12 December 2020

Heterogeneity of type I von Willebrand disease: evidence for a subgroup with an abnormal von Willebrand factor

1 reference

12 December 2020

Plasma concentration of von Willebrand factor in acute myocardial infarction

1 reference

12 December 2020

Mechanisms of shear-induced platelet adhesion and aggregation

1 reference

12 December 2020

A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C-catalyzed inactivation

1 reference

12 December 2020

Modification of von Willebrand disease after liver transplantation

1 reference

12 December 2020

New assay for measuring binding of platelet glycoprotein IIb/IIIa to unpurified von Willebrand factor

1 reference

12 December 2020

10.1097/MBC.0000000000000065

Identifiers

DOI

1 reference

21 August 2017

1 reference

PMC publication ID

3969155

21 August 2017

PubMed publication ID

24448155

1 reference

PMC publication ID

3969155