Polymeric micelles as a new drug carrier system and their required considerations for clinical trials (Q37679942)

21 August 2017

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title

Polymeric micelles as a new drug carrier system and their required considerations for clinical trials (English)

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21 August 2017

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Masayuki Yokoyama

1

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PubMed ID

20095939

21 August 2017

language of work or name

English

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publication date

1 February 2010

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Expert Opinion on Drug Delivery

21 August 2017

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21 August 2017

7

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21 August 2017

2

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21 August 2017

145-158

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Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles: in vivo evaluation of anti-cancer activity.

21 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Preclinical and clinical studies of anticancer agent-incorporating polymer micelles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Polymeric micellar delivery systems in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Poly (amino acid) micelle nanocarriers in preclinical and clinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Multicenter phase II trial of Genexol-PM, a novel Cremophor-free, polymeric micelle formulation of paclitaxel, with cisplatin in patients with advanced non-small-cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Flexible filaments for in vivo imaging and delivery: persistent circulation of filomicelles opens the dosage window for sustained tumor shrinkage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Shape effects of filaments versus spherical particles in flow and drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Polymeric micelles for drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Polymeric micelles for delivery of poorly water-soluble compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Amphiphilic block copolymers for drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

21 January 2018

Liposomal doxorubicin

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Pros and cons of the liposome platform in cancer drug targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Pegylated liposomal doxorubicin-related palmar-plantar erythrodysesthesia ('hand-foot' syndrome).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

NK105, a paclitaxel-incorporating micellar nanoparticle, is a more potent radiosensitising agent compared to free paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Antitumor activity of NK012 combined with cisplatin against small cell lung cancer and intestinal mucosal changes in tumor-bearing mouse after treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Potent antitumor effect of SN-38-incorporating polymeric micelle, NK012, against malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Antitumor effect of SN-38-releasing polymeric micelles, NK012, on spontaneous peritoneal metastases from orthotopic gastric cancer in mice compared with irinotecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Enhanced distribution of NK012, a polymeric micelle-encapsulated SN-38, and sustained release of SN-38 within tumors can beat a hypovascular tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Novel SN-38-incorporated polymeric micelle, NK012, strongly suppresses renal cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Design of Environment‐Sensitive Supramolecular Assemblies for Intracellular Drug Delivery: Polymeric Micelles that are Responsive to Intracellular pH Change

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Recent progress in tumor pH targeting nanotechnology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Stimuli-sensitive polymeric micelles as anticancer drug carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Incorporation of water-insoluble anticancer drug into polymeric micelles and control of their particle size

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Reduction of the side effects of an antitumor agent, KRN5500, by incorporation of the drug into polymeric micelles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Incorporation of the anticancer agent KRN5500 into polymeric micelles diminishes the pulmonary toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Block copolymer micelles for the encapsulation and delivery of amphotericin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Micelles self-assembled from poly(ethylene oxide)-block-poly(N-hexyl stearate L-aspartamide) by a solvent evaporation method: effect on the solubilization and haemolytic activity of amphotericin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Polymer design and incorporation methods for polymeric micelle carrier system containing water-insoluble anti-cancer agent camptothecin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Block copolymer design for camptothecin incorporation into polymeric micelles for passive tumor targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Preparation of micelle-forming polymer-drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

A novel covalent modification of antibodies at their amino groups with retention of antigen-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Pluronic block copolymers for overcoming drug resistance in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

An essential relationship between ATP depletion and chemosensitizing activity of Pluronic block copolymers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Prevention of MDR development in leukemia cells by micelle-forming polymeric surfactant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Pharmaceutical and biomedical differences between micellar doxorubicin (NK911) and liposomal doxorubicin (Doxil).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Histological study on side effects and tumor targeting of a block copolymer micelle on rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Influence of serum and albumins from different species on stability of camptothecin-loaded micelles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Preparation of camptothecin-loaded polymeric micelles and evaluation of their incorporation and circulation stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Enhanced antitumor effect of camptothecin loaded in long-circulating polymeric micelles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Polymeric micelles modified by folate-PEG-lipid for targeted drug delivery to cancer cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Biodistribution characteristics of all-trans retinoic acid incorporated in liposomes and polymeric micelles following intravenous administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Anti-tumor effect of all-trans retinoic acid loaded polymeric micelles in solid tumor bearing mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Block copolymer design for stable encapsulation of N-(4-hydroxyphenyl)retinamide into polymeric micelles in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' release control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Particle size-dependent triggering of accelerated blood clearance phenomenon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425240903436479

10.1517/17425240903436479

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

20095939