Troubleshooting methods: Using intravital microscopy in drug research (Q37680428)

21 August 2017

1 reference

title

Troubleshooting methods: Using intravital microscopy in drug research (English)

1 reference

21 August 2017

Ellen L Hughes

1

1 reference

PubMed ID

20097299

21 August 2017

Felicity N E Gavins

series ordinal

2

1 reference

21 August 2017

25 January 2010

1 reference

Journal of Pharmacological and Toxicological Methods

21 August 2017

1 reference

21 August 2017

61

1 reference

21 August 2017

2

1 reference

21 August 2017

102-112

1 reference

Dynamics of CNS barriers: evolution, differentiation, and modulation

21 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Neutrophil accumulation induced by bacterial lipopolysaccharide: effects of dexamethasone and annexin 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Aprotinin improves cerebral protection: evidence from a survival porcine model.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

In vivo analysis of cone survival in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Effects of Oral Administration of Purified Micronized Flavonoid Fraction on Increased Microvascular Permeability Induced by Various Agents and on Ischemia/Reperfusion in the Hamster Cheek Pouch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Temporal heterogeneity in blood supply in human tumor xenografts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

A carbon chamber for vital microscopy of bone healing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

An animal model for the analysis of cochlear blood flow [corrected] disturbance and hearing threshold in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Thrombus formation: direct real-time observation and digital analysis of thrombus assembly in a living mouse by confocal and widefield intravital microscopy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Hepatic platelet and leukocyte adherence during endotoxemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

The role of the granuloma in expansion and dissemination of early tuberculous infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

A novel method to analyze leukocyte rolling behavior in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

In vivo microcartography and subcellular imaging of tumor angiogenesis: a novel platform for translational angiogenesis research.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Platelet PECAM-1 inhibits thrombus formation in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Revascularization of skeletal muscle transplanted into the hamster cheek pouch: intravital and light microscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Butanol-extracted lipoteichoic acid induces in vivo leukocyte adhesion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Functional and ultrastructural analysis of annexin A1 and its receptor in extravasating neutrophils during acute inflammation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Tumor vascularity assessed by magnetic resonance imaging and intravital microscopy imaging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Intravital microscopy for the study of mouse microcirculation in anti-inflammatory drug research: focus on the mesentery and cremaster preparations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in murine acute myocardial infarct.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Inflammation-induced modulation of cellular galectin-1 and -3 expression in a model of rat peritonitis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Perivascular tissue pharmacokinetics of dipyridamole.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Leukocyte-versus microparticle-mediated tissue factor transfer during arteriolar thrombus development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Intravital microscopy on a closed cranial window in mice: a model to study trigeminovascular mechanisms involved in migraine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Relevance of L-selectin shedding for leukocyte rolling in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Femur window--a new approach to microcirculation of living bone in situ

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Altered microvascular hemodynamics during the induction and perpetuation of chronic gut inflammation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

T-lymphocyte entry into the central nervous system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Injury of the blood brain barrier and up-regulation of icam-1 in polymicrobial sepsis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

In vivo visualization of vascular leakage in photochemically induced cortical infarction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

PR-39, a potent neutrophil inhibitor, attenuates myocardial ischemia-reperfusion injury in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Platelet and leukocyte adhesion in the microvasculature at the cerebral surface immediately after subarachnoid hemorrhage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Intravital microscopy identifies selectins that regulate T cell traffic into allografts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Bucillamine improves hepatic microcirculation and reduces hepatocellular injury after liver warm ischaemia-reperfusion injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Dynamic Visualization of Thrombopoiesis Within Bone Marrow

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Elevated levels of homocysteine compromise blood-brain barrier integrity in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Observation of the blood-brain barrier function and vasomotor response in rat microcirculation using intravital fluorescence microscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Postischemic vascular permeability requires both TLR-2 and TLR-4, but only TLR-2 mediates the transendothelial migration of leukocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Role of integrin alpha(v)beta3 in the early phase of liver metastasis: PET and IVM analyses.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Platelets: developmental biology, physiology, and translatable platforms for preclinical investigation and drug development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Permissive range of hypercapnia for improved peripheral microcirculation and cardiac output in rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Histamine can induce leukocyte rolling in rat mesenteric venules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Getting to the site of inflammation: the leukocyte adhesion cascade updated

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Visualization of neuromuscular junctions over periods of several months in living mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Leukocyte recruitment in the airways: an intravital microscopic study of rat tracheal microcirculation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Airway distension promotes leukocyte recruitment in rat tracheal circulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

A new model for studying the revascularization of skin grafts in vivo: the role of angiogenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilution

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Neutrophil motility in vivo using zebrafish

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

In vivo imaging of mammalian cochlear blood flow using fluorescence microendoscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Leukocyte-endothelium interactions after hemorrhagic shock/reperfusion and cecal ligation/puncture: an intravital microscopic study in rat mesentery.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Differential roles of ICAM-1 and VCAM-1 in leukocyte-endothelial cell interactions in skin and brain of MRL/faslpr mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

A novel hydrodynamic method for microvascular flow enhancement

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Two-photon imaging of dendritic spine development in the mouse cortex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

When two is better than one: elements of intravital microscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Structural response of microcirculatory networks to changes in demand: information transfer by shear stress.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Nerve terminal remodeling visualized in living mice by repeated examination of the same neuron

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

In vivo microscopy of rat skeletal muscle after ischemia using labelled neutrophils (PMN).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Low-flow reperfusion after myocardial ischemia enhances leukocyte accumulation in coronary microcirculation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Effects of estrogen on leukocyte adhesion after transient forebrain ischemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Constrictor responses to noradrenaline, hemodynamic profile, and superoxide levels measured by hydroethidine oxidation in diabetic rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Cardiovascular imaging using two-photon microscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

IV vs. IA TPA in acute ischemic stroke with CT angiographic evidence of major vessel occlusion: a feasibility study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Edaravone preserves coronary microvascular endothelial function after ischemia/reperfusion on the beating canine heart in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

A separate role for ICAM-1 and fluid shear in regulating leukocyte interactions with straight regions of venular wall and venular convergences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

TNF-alpha activation of arterioles and venules alters distribution and levels of ICAM-1 and affects leukocyte-endothelial cell interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Accuracy of allometrically predicted pharmacokinetic parameters in humans: role of species selection.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Microvascular mechanisms of histamine-induced potentiation of leukocyte adhesion evoked by chemoattractants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Imaging the living inner ear using intravital confocal microscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Traffic of leukocytes in the central nervous system is associated with chemokine up-regulation in a severe model of herpes simplex encephalitis: an intravital microscopy study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Local heat produces a shear-mediated biphasic response in the thermoregulatory microcirculation of the Pallid bat wing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Comparison of combined venous and arterial thrombolysis with primary arterial therapy using recombinant tissue plasminogen activator in acute ischemic stroke

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Intact endothelium-dependent dilation and conducted responses in resistance vessels of hypercholesterolemic mice in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta and tumour necrosis factor-alpha in mouse cremasteric venules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Effects of fractionated radiation on the brain vasculature in a murine model: blood-brain barrier permeability, astrocyte proliferation, and ultrastructural changes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Molecular imaging of vessels in mouse models of disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

Response to intra-arterial and combined intravenous and intra-arterial thrombolytic therapy in patients with distal internal carotid artery occlusion.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.004

10.1016/J.VASCN.2010.01.004

7 January 2021

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

20097299