The potential of metabolomics for Leishmania research in the post-genomics era. (Q37682957)

22 August 2017

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title

The potential of metabolomics for Leishmania research in the post-genomics era. (English)

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22 August 2017

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Saskia Decuypere

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22 August 2017

Rainer Breitling

6

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author name string

Richard A Scheltema

1

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22 August 2017

Ruben T'kindt

3

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22 August 2017

Jean-Claude Dujardin

4

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22 August 2017

Graham H Coombs

5

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22 August 2017

29 January 2010

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22 August 2017

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22 August 2017

137

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22 August 2017

9

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22 August 2017

1291-1302

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Global gene expression in Leishmania.

22 August 2017

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https://api.crossref.org/works/10.1017%2FS0031182009992022

Living in a phagolysosome; metabolism of Leishmania amastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

LC-MS-based metabonomics analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Post-transcriptional regulation of gene expression in trypanosomes and leishmanias

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Comparative two-dimensional gel electrophoresis maps for promastigotes of Leishmania amazonensis and Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Genomic and proteomic expression analysis of Leishmania promastigote and amastigote life stages: the Leishmania genome is constitutively expressed.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

New surveyor tools for charting microbial metabolic maps.

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

HMDB: the Human Metabolome Database

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

Interferences and contaminants encountered in modern mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

Ab initio prediction of metabolic networks using Fourier transform mass spectrometry data

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites.

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

Metabolomics and systems biology: making sense of the soup

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

The unusual gene organization of Leishmania major chromosome 1 may reflect novel transcription processes

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

Towards de novo identification of metabolites by analyzing tandem mass spectra

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

PubChem: a public information system for analyzing bioactivities of small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Developmentally induced changes of the proteome in the protozoan parasite Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Metabolic control theory: its role in microbiology and biotechnology

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

The KEGG databases at GenomeNet

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

The genome of the kinetoplastid parasite, Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Microbial metabolomics: toward a platform with full metabolome coverage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Relation between variation in copy number of ribosomal RNA encoding genes and size of harbouring chromosomes in Leishmania of subgenus Viannia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Kinetoplastid genomics: the thin end of the wedge

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Interfacing the Orbitrap Mass Analyzer to an Electrospray Ion Source

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Transcriptome analysis during the process of in vitro differentiation of Leishmania donovani using genomic microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Advanced sequencing technologies and their wider impact in microbiology

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

Comparative genomics: from genotype to disease phenotype in the leishmaniases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

METLIN: a metabolite mass spectral database

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Gp63 gene polymorphism and population structure of Leishmania donovani complex: influence of the host selection pressure?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Differential gene expression analysis in antimony-unresponsive Indian kala azar (visceral leishmaniasis) clinical isolates by DNA microarray.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Metabolomics by numbers: acquiring and understanding global metabolite data

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Proteomic analysis of miltefosine-resistant Leishmania reveals the possible involvement of eukaryotic initiation factor 4A (eIF4A).

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Proteomic analysis of wild type and arsenite-resistant Leishmania donovani

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

Effective quenching processes for physiologically valid metabolite profiling of suspension cultured Mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

Analysis of the Leishmania donovani transcriptome reveals an ordered progression of transient and permanent changes in gene expression during differentiation

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

Comparison of quenching and extraction methodologies for metabolome analysis of Lactobacillus plantarum

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

Retooling Leishmania metabolism: from sand fly gut to human macrophage

21 January 2018

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https://api.crossref.org/works/10.1017%2FS0031182009992022

LIPID MAPS online tools for lipid research

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Down regulation of KMP-11 in Leishmania infantum axenic antimony resistant amastigotes as revealed by a proteomic screen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Probabilistic assignment of formulas to mass peaks in metabolomics experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Measuring the metabolome: current analytical technologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Comparative genomic analysis of three Leishmania species that cause diverse human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Structure, dynamics and function of Leishmania genome: resolving the puzzle of infection, genetics and evolution?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Gas chromatography/mass spectrometry in metabolic profiling of biological fluids

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Proteome mapping of the protozoan parasite Leishmania and application to the study of drug targets and resistance mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Applications of next-generation sequencing technologies in functional genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

LeishCyc: a biochemical pathways database for Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

A combined proteomic and transcriptomic approach to the study of stage differentiation in Leishmania infantum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Progressive peak clustering in GC-MS Metabolomic experiments applied to Leishmania parasites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Upregulation of surface proteins in Leishmania donovani isolated from patients of post kala-azar dermal leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

Metabolite profiling: from diagnostics to systems biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

7 January 2021

Plasticity of gp63 gene organization in Leishmania (Viannia) braziliensis and Leishmania (Viannia) peruviana

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

7 January 2021

Cold glycerol-saline: the promising quenching solution for accurate intracellular metabolite analysis of microbial cells

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

7 January 2021

Expression profiling by whole-genome interspecies microarray hybridization reveals differential gene expression in procyclic promastigotes, lesion-derived amastigotes, and axenic amastigotes in Leishmania mexicana

1 reference

https://api.crossref.org/works/10.1017%2FS0031182009992022

7 January 2021

10.1017/S0031182009992022

Identifiers

DOI

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22 August 2017

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