Cryo electron microscopy structures of Hsp100 proteins: crowbars in or out? (Q37687108)

22 August 2017

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title

Cryo electron microscopy structures of Hsp100 proteins: crowbars in or out? (English)

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cryogenic electron microscopy

22 August 2017

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2

Helen R Saibil

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22 August 2017

Petra Wendler

1

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22 August 2017

1 February 2010

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Biochemistry and Cell Biology

22 August 2017

8

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based on heuristic

inferred from page(s)

published in

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22 August 2017

88

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22 August 2017

1

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22 August 2017

89-96

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The molecular chaperone Hsp104--a molecular machine for protein disaggregation

22 August 2017

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Defining a pathway of communication from the C-terminal peptide binding domain to the N-terminal ATPase domain in a AAA protein

21 January 2018

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Three dimensional reconstructions of spherical viruses by fourier synthesis from electron micrographs

21 January 2018

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Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change

21 January 2018

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Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

21 January 2018

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Hsp104 and ClpB: protein disaggregating machines

21 January 2018

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Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity

21 January 2018

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Detection and separation of heterogeneity in molecular complexes by statistical analysis of their two-dimensional projections.

21 January 2018

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Cryo-electron microscopy as an investigative tool: the ribosome as an example

21 January 2018

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Single-particle imaging of macromolecules by cryo-electron microscopy

21 January 2018

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Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

21 January 2018

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Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network

21 January 2018

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M domains couple the ClpB threading motor with the DnaK chaperone activity.

21 January 2018

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Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants

21 January 2018

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The crystal structure of murine p97/VCP at 3.6A

21 January 2018

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The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state

21 January 2018

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Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB

21 January 2018

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Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB.

21 January 2018

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Roles of individual domains and conserved motifs of the AAA+ chaperone ClpB in oligomerization, ATP hydrolysis, and chaperone activity

21 January 2018

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Common and specific mechanisms of AAA+ proteins involved in protein quality control

21 January 2018

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Estimation of variance in single-particle reconstruction using the bootstrap technique.

21 January 2018

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UCSF Chimera--a visualization system for exploratory research and analysis

21 January 2018

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Heat shock protein 101 plays a crucial role in thermotolerance in Arabidopsis.

21 January 2018

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Three-dimensional reconstruction of single particles from random and nonrandom tilt series

21 January 2018

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Macromolecular structure determination by cryo-electron microscopy

21 January 2018

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Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization.

21 January 2018

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The ATPase activity of Hsp104, effects of environmental conditions and mutations.

21 January 2018

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Subunit interactions influence the biochemical and biological properties of Hsp104

21 January 2018

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Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region

21 January 2018

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The chaperone function of ClpB from Thermus thermophilus depends on allosteric interactions of its two ATP-binding sites

21 January 2018

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SWISS-MODEL: An automated protein homology-modeling server

21 January 2018

1 reference

An approach to examining model dependence in EM reconstructions using cross-validation

21 January 2018

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The Clp proteins: proteolysis regulators or molecular chaperones?

21 January 2018

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Angular reconstitution: a posteriori assignment of projection directions for 3D reconstruction.

21 January 2018

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Single-particle electron cryo-microscopy: towards atomic resolution.

21 January 2018

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Unscrambling an egg: protein disaggregation by AAA+ proteins

21 January 2018

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Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104.

21 January 2018

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Motor mechanism for protein threading through Hsp104.

21 January 2018

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Coupling and dynamics of subunits in the hexameric AAA+ chaperone ClpB.

21 January 2018

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Three-dimensional reconstruction from a single-exposure, random conical tilt series applied to the 50S ribosomal subunit of Escherichia coli

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1139/O09-164

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22 August 2017

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PubMed ID

20130682